Evaluation of tumour heterogeneity by 18F-fluoroestradiol PET as a predictive measure in breast cancer patients receiving palbociclib combined with endocrine treatment

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30.

PubMed  Article  Google Scholar 

Howlader N, Altekruse SF, Li CI, Chen VW, Clarke CA, Ries LA, Cronin KA: US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status. J Natl Cancer Inst 2014;106(5).

Rugo HS, Rumble RB, Macrae E, Barton DL, Connolly HK, Dickler MN, Fallowfield L, Fowble B, Ingle JN, Jahanzeb M, et al. Endocrine Therapy for hormone receptor-positive metastatic breast cancer: american society of clinical oncology guideline. J Clin Oncol Off J Am Soc Clin Oncol. 2016;34(25):3069–103.

CAS  Article  Google Scholar 

Cardoso F, Senkus E, Costa A, Papadopoulos E, Aapro M, André F, Harbeck N, Aguilar Lopez B, Barrios CH, Bergh J, et al. 4th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 4)†. Ann Oncol Off J Eur Soc Med Oncol. 2018;29(8):1634–57.

CAS  Article  Google Scholar 

Spring LM, Wander SA, Andre F, Moy B, Turner NC, Bardia A. Cyclin-dependent kinase 4 and 6 inhibitors for hormone receptor-positive breast cancer: past, present, and future. Lancet (London, England). 2020;395(10226):817–27.

CAS  Article  Google Scholar 

Turner NC, Ro J, André F, Loi S, Verma S, Iwata H, Harbeck N, Loibl S, Huang Bartlett C, Zhang K, et al. Palbociclib in hormone-receptor-positive advanced breast cancer. N Engl J Med. 2015;373(3):209–19.

CAS  PubMed  Article  Google Scholar 

Li Y, Li W, Gong C, Zheng Y, Ouyang Q, Xie N, Qu Q, Ge R, Wang B. A multicenter analysis of treatment patterns and clinical outcomes of subsequent therapies after progression on palbociclib in HR+/HER2- metastatic breast cancer. Ther Adv Med Oncol. 2021;13:17588359211022890.

CAS  PubMed  PubMed Central  Google Scholar 

Herrera-Abreu MT, Palafox M, Asghar U, Rivas MA, Cutts RJ, Garcia-Murillas I, Pearson A, Guzman M, Rodriguez O, Grueso J, et al. Early adaptation and acquired resistance to CDK4/6 inhibition in estrogen receptor-positive breast cancer. Can Res. 2016;76(8):2301–13.

CAS  Article  Google Scholar 

Pandey K, An HJ, Kim SK, Lee SA, Kim S, Lim SM, Kim GM, Sohn J, Moon YW. Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: a review. Int J Cancer. 2019;145(5):1179–88.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Turner NC, Liu Y, Zhu Z, Loi S, Colleoni M, Loibl S, DeMichele A, Harbeck N, André F, Bayar MA, et al. Cyclin E1 expression and palbociclib efficacy in previously treated hormone receptor-positive metastatic breast cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2019;37(14):1169–78.

CAS  Article  Google Scholar 

Del Re M, Bertolini I, Crucitta S, Fontanelli L, Rofi E, De Angelis C, Diodati L, Cavallero D, Gianfilippo G, Salvadori B, et al. Overexpression of TK1 and CDK9 in plasma-derived exosomes is associated with clinical resistance to CDK4/6 inhibitors in metastatic breast cancer patients. Breast Cancer Res Treat. 2019;178(1):57–62.

PubMed  Article  CAS  Google Scholar 

Darrigues L, Pierga JY, Bernard-Tessier A, Bièche I, Silveira AB, Michel M, Loirat D, Cottu P, Cabel L, Dubot C, et al. Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients. Breast Cancer Res BCR. 2021;23(1):31.

CAS  PubMed  Article  Google Scholar 

O’Leary B, Finn RS, Turner NC. Treating cancer with selective CDK4/6 inhibitors. Nat Rev Clin Oncol. 2016;13(7):417–30.

CAS  PubMed  Article  Google Scholar 

Miller TW, Balko JM, Fox EM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M, Jiang A, Smith RA, Maira SM, et al. ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer. Cancer Discov. 2011;1(4):338–51.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fang H, Huang D, Yang F, Guan X. Potential biomarkers of CDK4/6 inhibitors in hormone receptor-positive advanced breast cancer. Breast Cancer Res Treat. 2018;168(2):287–97.

CAS  PubMed  Article  Google Scholar 

Patel HK, Tao N, Lee KM, Huerta M, Arlt H, Mullarkey T, Troy S, Arteaga CL, Bihani T. Elacestrant (RAD1901) exhibits anti-tumor activity in multiple ER+ breast cancer models resistant to CDK4/6 inhibitors. Breast Cancer Res BCR. 2019;21(1):146.

CAS  PubMed  Article  Google Scholar 

Sieuwerts AM, Inda MA, Smid M, van Ooijen H, van de Stolpe A, Martens JWM, Verhaegh WFJ. ER and PI3K pathway activity in primary ER positive breast cancer is associated with progression-free survival of metastatic patients under first-line tamoxifen. Cancers. 2020;12(4):802.

CAS  Article  Google Scholar 

Sighoko D, Liu J, Hou N, Gustafson P, Huo D. Discordance in hormone receptor status among primary, metastatic, and second primary breast cancers: Biological difference or misclassification? Oncologist. 2014;19(6):592–601.

PubMed  PubMed Central  Article  Google Scholar 

Schrijver W, Suijkerbuijk KPM, van Gils CH, van der Wall E, Moelans CB, van Diest PJ. Receptor conversion in distant breast cancer metastases: a systematic review and meta-analysis. J Natl Cancer Inst. 2018;110(6):568–80.

PubMed  Article  Google Scholar 

van Es SC, van der Vegt B, Bensch F, Gerritse S, van Helden EJ, Boon E, Angus L, Overbosch J, der Menke-van Houven VO, Verheul HM, et al. Decalcification of breast cancer bone metastases with EDTA does not affect ER PR and HER2 results. Am J Surg Pathol. 2019;43(10):1355–60.

PubMed  Article  Google Scholar 

Lindström LS, Yau C, Czene K, Thompson CK, Hoadley KA, Van’t Veer LJ, Balassanian R, Bishop JW, Carpenter PM, Chen YY, et al. Intratumor heterogeneity of the estrogen receptor and the long-term risk of fatal breast cancer. J Natl Cancer Inst. 2018;110(7):726–33.

PubMed  PubMed Central  Article  Google Scholar 

Liao GJ, Clark AS, Schubert EK, Mankoff DA. 18F-fluoroestradiol PET: current status and potential future clinical applications. J Nucl Med. 2016;57(8):1269–75.

CAS  PubMed  Article  Google Scholar 

Kurland BF, Wiggins JR, Coche A, Fontan C, Bouvet Y, Webner P, Divgi C, Linden HM. Whole-body characterization of estrogen receptor status in metastatic breast cancer with 16α-18f-fluoro-17β-estradiol positron emission tomography: meta-analysis and recommendations for integration into clinical applications. Oncologist. 2020;25(10):835–44.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Liu C, Xu X, Yuan H, Zhang Y, Zhang Y, Song S, Yang Z. Dual Tracers of 16α-[18F]fluoro-17β-Estradiol and [18F]fluorodeoxyglucose for prediction of progression-free survival after fulvestrant therapy in patients with HR+/HER2- metastatic breast cancer. Front Oncol. 2020;10: 580277.

PubMed  PubMed Central  Article  Google Scholar 

He M, Liu C, Shi Q, Sun Y, Zhang Y, Xu X, Yuan H, Zhang Y, Liu Y, Liu G, et al. The predictive value of early changes in (18) F-fluoroestradiol positron emission tomography/computed tomography during fulvestrant 500 mg therapy in patients with estrogen receptor-positive metastatic breast cancer. Oncologist. 2020;25(11):927–36.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kurland BF, Peterson LM, Lee JH, Schubert EK, Currin ER, Link JM, Krohn KA, Mankoff DA, Linden HM. Estrogen receptor binding (18F-FES PET) and glycolytic activity (18F-FDG PET) predict progression-free survival on endocrine therapy in patients with ER+ breast cancer. Clin Cancer Res. 2017;23(2):407–15.

CAS  PubMed  Article  Google Scholar 

Yang Z, Sun Y, Xu X, Zhang Y, Zhang J, Xue J, Wang M, Yuan H, Hu S, Shi W, et al. The assessment of estrogen receptor status and its intratumoral heterogeneity in patients with breast cancer by using 18F-fluoroestradiol PET/CT. Clin Nucl Med. 2017;42(6):421–7.

PubMed  Article  Google Scholar 

van Kruchten M, Glaudemans A, de Vries EFJ, Schröder CP, de Vries EGE, Hospers GAP. Positron emission tomography of tumour [(18)F]fluoroestradiol uptake in patients with acquired hormone-resistant metastatic breast cancer prior to oestradiol therapy. Eur J Nucl Med Mol Imaging. 2015;42(11):1674–81.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Chae SY, Ahn SH, Kim SB, Han S, Lee SH, Oh SJ, Lee SJ, Kim HJ, Ko BS, Lee JW, et al. Diagnostic accuracy and safety of 16α-[(18)F]fluoro-17β-oestradiol PET-CT for the assessment of oestrogen receptor status in recurrent or metastatic lesions in patients with breast cancer: a prospective cohort study. Lancet Oncol. 2019;20(4):546–55.

CAS  PubMed  Article  Google Scholar 

Liu C, Gong C, Liu S, Zhang Y, Zhang Y, Xu X, Yuan H, Wang B, Yang Z. (18)F-FES PET/CT influences the staging and management of patients with newly diagnosed estrogen receptor-positive breast cancer: a retrospective comparative study with (18)F-FDG PET/CT. Oncologist. 2019;24(12):e1277–85.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Boellaard R, Delgado-Bolton R, Oyen WJ, Giammarile F, Tatsch K, Eschner W, Verzijlbergen FJ, Barrington SF, Pike LC, Weber WA, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42(2):328–54.

CAS  PubMed  Article  Google Scholar 

Li Y, Liu C, Wang B, Hu X, Gong C, Zhao Y, Xie Y, Zhang Y, Song S, Yang Z, et al. Prediction of pretreatment 18F-FDG-PET/CT parameters on the outcome of first-line therapy in patients with metastatic breast cancer. Int J Gen Med. 2021;14:1797–809.

PubMed  PubMed Central  Article  Google Scholar 

Wang Y, Ayres KL, Goldman DA, Dickler MN, Bardia A, Mayer IA, Winer E, Fredrickson J, Arteaga CL, Baselga J, et al. (18)F-Fluoroestradiol PET/CT measurement of estrogen receptor suppression during a Phase I trial of the novel estrogen receptor-targeted therapeutic GDC-0810: using an imaging biomarker to guide drug dosage in subsequent trials. Clin Cancer Res. 2017;23(12):3053–60.

CAS  PubMed  Article  Google Scholar 

Lu Y, Tong Y, Chen X, Shen K. Association of biomarker discrepancy and treatment decision, disease outcome in recurrent/metastatic breast cancer patients. Front Oncol. 2021;11: 638619.

PubMed  PubMed Central  Article  Google Scholar 

Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, et al. Estrogen/progesterone receptor and HER2 discordance between primary tumor and brain metastases in breast cancer and its effect on treatment and survival. Neuro Oncol. 2020;22(9):1359–67.

CAS  PubMed  PubMed Central  Article 

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