Nefarious NTRK Oncogenic Fusions in Pediatric Sarcomas: Too Many to Trk

Maega Aepala is a researcher in the Donoghue group in the Department of Chemistry & Biochemistry at the University of California, San Diego, conducting research on the oncogenic fusion protein SQSTM1-NTRK1 in the Donoghue research group.

Malalage Nicole Peiris recently completed her doctoral research in the Donoghue group in the Department of Chemistry & Biochemistry at the University of California, San Diego, conducting research on the oncogenic fusion protein BCR-FGFR1. She obtained her Bachelor’s degree in Biochemistry and Molecular Biology from the University of California, Davis. She is currently a postdoctoral research studying therapeutic approaches to triple negative breast cancer at Brigham and Women's Hospital in Boston.

Zian Jiang is a native of Shanghai, China. She completed her Bachelor’s degree in 2020 at the University of California, San Diego, with a major in Biochemistry/Chemistry. She is currently a graduate student in the Donoghue lab, conducting research on the oncogenic fusion protein EML4-NTRK3.

Wei Yang is a native of JiangXi, China. He completed his Bachelor’s degree in 2020 at the University of California, San Diego, with a major in Chemistry. He is currently a graduate student in the Donoghue lab, conducting research on the oncogenic fusion protein NACC2-NTRK2.

April N. Meyer is a Staff Research Associate in the Donoghue laboratory at the University of California, San Diego. She earned her Bachelor’s degree from the University of California, San Diego in the Department of Chemistry & Biochemistry. Her areas of expertise include molecular biology, FGFR signaling., and NTRK signaling.

Daniel J. Donoghue is a Professor in the Department of Chemistry & Biochemistry at UC San Diego. He received his graduate training with Phillip A. Sharp at MIT, and postdoctoral training with Tony Hunter at the Salk Institute before joining UC San Diego. He has a lifelong interest in Receptor Tyrosine Kinases and their roles in human cancer.

© 2022 The Author(s). Published by Elsevier Ltd.

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