Bonam SR, Wang F, Muller S. Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019;18(12):923–48.

CAS  Article  Google Scholar 

Lamming DW, Bar-Peled L. Lysosome: the metabolic signaling hub. Traffic. 2019;20(1):27–38.

CAS  Article  Google Scholar 

Savini M, Zhao Q, Wang MC. Lysosomes: signaling hubs for metabolic sensing and longevity. Trends Cell Biol. 2019;29(11):876–87.

CAS  Article  Google Scholar 

Villegas F, Lehalle D, Mayer D, Rittirsch M, Stadler MB, Zinner M, Olivieri D, Vabres P, Duplomb-Jego L, De Bont E, Duffourd Y, Duijkers F, Avila M, Genevieve D, Houcinat N, Jouan T, Kuentz P, Lichtenbelt KD, Thauvin-Robinet C, St-Onge J, Thevenon J, van Gassen KLI, van Haelst M, van Koningsbruggen S, Hess D, Smallwood SA, Riviere JB, Faivre L, Betschinger J. Lysosomal signaling licenses embryonic stem cell differentiation via inactivation of Tfe3. Cell Stem Cell. 2019;24(2):257-270-e258.

Article  Google Scholar 

Zhang L, Sheng R, Qin Z. The lysosome and neurodegenerative diseases. Acta Biochim Biophys Sin (Shanghai). 2009;41(6):437–45.

CAS  Article  Google Scholar 

Sasikumar AN, Killilea DW, Kennedy BK, Brem RB. Potassium restriction boosts vacuolar acidity and extends lifespan in yeast. Exp Gerontol. 2019;120:101–6.

CAS  Article  Google Scholar 

Hagan AE, Farrington CA, Wall GC, Belz MM. Sodium polystyrene sulfonate for the treatment of acute hyperkalemia: a retrospective study. Clin Nephrol. 2016;85(1):38–43.

Article  Google Scholar 

Moriyama Y, Takano T, Ohkuma S. Acridine orange as a fluorescent probe for lysosomal proton pump. J Biochem. 1982;92(4):1333–6.

CAS  Article  Google Scholar 

Chang JT, Kumsta C, Hellman AB, Adams LM, Hansen M. Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging. Elife. 2017;6.

Wibo M, Poole B. Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1. J Cell Biol. 1974;63(2 Pt 1):430–40.

CAS  Article  Google Scholar 

McColl G, Roberts BR, Pukala TL, Kenche VB, Roberts CM, Link CD, Ryan TM, Masters CL, Barnham KJ, Bush AI, Cherny RA. Utility of an improved model of amyloid-beta (Abeta(1)(-)(4)(2)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease. Mol Neurodegener. 2012;7:57.

CAS  Article  Google Scholar 

Anand N, Holcom A, Broussalian M, Schmidt M, Chinta SJ, Lithgow GJ, Andersen JK, Chamoli M. Dysregulated iron metabolism in C elegans catp-6/ATP13A2 mutant impairs mitochondrial function. Neurobiol Dis. 2020;139:104786.

Sun Y, Li M, Zhao D, Li X, Yang C, Wang X. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Elife. 2020;9.

Davis MW, Somerville D, Lee RY, Lockery S, Avery L, Fambrough DM. Mutations in the Caenorhabditis elegans Na, K-ATPase alpha-subunit gene, eat-6, disrupt excitable cell function. J Neurosci. 1995;15(12):8408–18.

CAS  Article  Google Scholar 

Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 2005;19(13):1544–55.

CAS  Article  Google Scholar 

Marwaha R and M Sharma (2017). “DQ-Red BSA trafficking assay in cultured cells to assess cargo delivery to lysosomes.” Bio Protoc 7(19).

Carmona-Gutierrez D, Hughes AL, Madeo F, Ruckenstuhl C. The crucial impact of lysosomes in aging and longevity. Ageing Res Rev. 2016;32:2–12.

CAS  Article  Google Scholar 

Kaplan JH. Biochemistry of Na, K-ATPase. Annu Rev Biochem. 2002;71:511–35.

CAS  Article  Google Scholar 

Nepal M, Bucaloiu ID, Norfolk ER. Hypernatremia in a patient treated with sodium polystyrene sulfonate. Int J Nephrol Renovasc Dis. 2010;3:141–3.

CAS  Article  Google Scholar 

Rangarajan N, Kapoor I, Li S, Drossopoulos P, White KK, Madden VJ, Dohlman HG. Potassium starvation induces autophagy in yeast. J Biol Chem. 2020;295(41):14189–202.

CAS  Article  Google Scholar 

Vitvitsky VM, Garg SK, Keep RF, Albin RL, Banerjee R. Na+ and K+ ion imbalances in Alzheimer’s disease. Biochim Biophys Acta. 2012;1822(11):1671–81.

CAS  Article  Google Scholar 

Brenner S. The genetics of Caenorhabditis elegans. Genetics. 1974;77(1):71–94.

CAS  Article  Google Scholar 

Restif C, Ibanez-Ventoso C, Vora MM, Guo S, Metaxas D, Driscoll M. CeleST: computer vision software for quantitative analysis of C. elegans swim behavior reveals novel features of locomotion. PLoS Comput Biol. 2014;10(7):e1003702.

Article  Google Scholar