Aarts M et al (2003) A key role for TRPM7 channels in anoxic neuronal death. Cell 115:863–877
CAS PubMed Article Google Scholar
Abdalkader M et al (2018) Targeting Nrf2 to suppress ferroptosis and mitochondrial dysfunction in neurodegeneration. Front Neurosci 12:466
PubMed PubMed Central Article Google Scholar
Akopian A (2016) Role of TRP ion channels in physiology and pathology. Semin Immunopathol 38:275–276
Akpinar H et al (2016) The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: contribution of TRPM2 and TRPV1 channels. Sci Rep 6:37196
CAS PubMed PubMed Central Article Google Scholar
Albanese A et al (2020) The role of hypoxia-inducible factor post-translational modifications in regulating its localisation, stability, and activity. Int J Mol Sci 22:268
PubMed Central Article CAS Google Scholar
Almasi S et al (2018) TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem 293:3637–3650
CAS PubMed PubMed Central Article Google Scholar
Bai YT et al (2021) Hypoxia protects H9c2 cells against ferroptosis through SENP1-mediated protein DeSUMOylation. Int J Med Sci 18:1618–1627
CAS PubMed PubMed Central Article Google Scholar
Bao L et al (2019) The human transient receptor potential melastatin 2 ion channel modulates ROS through Nrf2. Sci Rep 9:14132
PubMed PubMed Central Article CAS Google Scholar
Brigelius-Flohe R, Maiorino M (2013) Glutathione peroxidases. Biochim Biophys Acta 1830:3289–3303
CAS PubMed Article Google Scholar
Castelli S et al (2021) ROS-dependent HIF1alpha activation under forced lipid catabolism entails glycolysis and mitophagy as mediators of higher proliferation rate in cervical cancer cells. J Exp Clin Cancer Res 40:94
CAS PubMed PubMed Central Article Google Scholar
Chen W et al (2016) Cancer statistics in China, 2015. CA Cancer J Clin 66:115–132
Chen X et al (2021) Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol 18:280–296
CAS PubMed Article Google Scholar
Cheng Q et al (2021) Erastin synergizes with cisplatin via ferroptosis to inhibit ovarian cancer growth in vitro and in vivo. J Obstet Gynaecol Res 47:2481–2491
CAS PubMed Article Google Scholar
Chinigo G, Fiorio Pla A, Gkika D (2020) TRP channels and small GTPases interplay in the main hallmarks of metastatic cancer. Front Pharmacol 11:581455
CAS PubMed PubMed Central Article Google Scholar
Digaleh H, Kiaei M, Khodagholi F (2013) Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy. Cell Mol Life Sci 70:4681–4694
CAS PubMed Article Google Scholar
Dixon SJ et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060–1072
CAS PubMed PubMed Central Article Google Scholar
Ferlay J et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386
CAS PubMed Article Google Scholar
Ghoochani A et al (2021) Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer. Cancer Res 81:1583–1594
CAS PubMed PubMed Central Article Google Scholar
Ha Kim K et al (2017) Suppressed ubiquitination of Nrf2 by p47(phox) contributes to Nrf2 activation. Free Radic Biol Med 113:48–58
PubMed Article CAS Google Scholar
Hara Y et al (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163–173
CAS PubMed Article Google Scholar
Hecquet CM et al (2008) Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability. Circ Res 102:347–355
CAS PubMed Article Google Scholar
Hopkins MM et al (2015) Inhibition of the transient receptor potential melastatin-2 channel causes increased DNA damage and decreased proliferation in breast adenocarcinoma cells. Int J Oncol 46:2267–2276
CAS PubMed PubMed Central Article Google Scholar
Katai H et al (2018) Five-year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese Gastric Cancer Association (2001–2007). Gastric Cancer 21:144–154
Koh DW et al (2015) Enhanced cytotoxicity in triple-negative and estrogen receptorpositive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel. Oncol Rep 34:1589–1598
CAS PubMed PubMed Central Article Google Scholar
Kolisek M et al (2005) Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell 18:61–69
CAS PubMed Article Google Scholar
La Rosa P et al (2021) The Nrf2 induction prevents ferroptosis in Friedreich’s Ataxia. Redox Biol 38:101791
PubMed Article CAS Google Scholar
LaGory EL, Giaccia AJ (2016) The ever-expanding role of HIF in tumour and stromal biology. Nat Cell Biol 18:356–365
CAS PubMed PubMed Central Article Google Scholar
Lange I et al (2008) Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils. Cell Calcium 44:604–615
CAS PubMed PubMed Central Article Google Scholar
Li F, Abuarab N, Sivaprasadarao A (2016) Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels. J Cell Sci 129:2016–2029
Li R, Jia Z, Zhu H (2019) Regulation of Nrf2 signaling. React Oxyg Species (Apex) 8:312–322
Lin R et al (2018) TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinoma. Mol Med Rep 17:7537–7544
CAS PubMed PubMed Central Google Scholar
Liu YV et al (2007) Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem 282:37064–37073
CAS PubMed Article Google Scholar
Liu Z et al (2020a) Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis. Toxicol Appl Pharmacol 407:115241
CAS PubMed Article Google Scholar
Liu P et al (2020b) NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway. Redox Biol 37:101702
CAS PubMed PubMed Central Article Google Scholar
Liu Y et al (2020c) Oroxylin A reverses hypoxia-induced cisplatin resistance through inhibiting HIF-1alpha mediated XPC transcription. Oncogene 39:6893–6905
CAS PubMed Article Google Scholar
Loboda A et al (2016) Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci 73:3221–3247
CAS PubMed PubMed Central Article Google Scholar
Miller BA, Zhang W (2011) TRP channels as mediators of oxidative stress. Adv Exp Med Biol 704:531–544
CAS PubMed Article Google Scholar
Miyanohara J et al (2018) TRPM2 channel aggravates CNS inflammation and cognitive impairment via activation of microglia in chronic cerebral hypoperfusion. J Neurosci 38:3520–3533
CAS PubMed PubMed Central Article Google Scholar
Ni S et al (2021) Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis. Free Radic Biol Med 169:271–282
CAS PubMed Article Google Scholar
Nilius B, Flockerzi V (2014) Mammalian transient rec
留言 (0)