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ORIGINAL ARTICLE
Year : 2022 | Volume
: 33
| Issue : 3 | Page : 130-135
Assessment of the balloon dilation efficiency in bladder neck contracture after transurethral interventions on the prostate
Shukhrat Anvarovich Abbosov1, Nikolay Ivanovich Sorokin2, Azizbek Bakhodirovich Shomarufov1, Aleksey Viktorovich Kadrev2, Mikheev Konstantin Vitalevich2, Abdukodir Abdukahharovich Fozilov3, Yalkin Saidovich Nadjimitdinov3, Ohobotov Dmitri Alexsandrovich2, Shukhrat Iskandarovich Giyasov3, Shukhrat Tursunovich Mukhtarov3, Farkhad Ataullaevich Akilov3, Armais Albertovich Kamalov2
1 Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University and Medical Scientific and Educational Center of Lomonosov Moscow State University, Moscow, Russia; Republican Specialized Scientific and Practical Medical Center of Urology, Tashkent, Uzbekistan
2 Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University and Medical Scientific and Educational Center of Lomonosov Moscow State University, Moscow, Russia
3 Republican Specialized Scientific and Practical Medical Center of Urology, Tashkent, Uzbekistan
Correspondence Address:
Shukhrat Anvarovich Abbosov
Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow
Source of Support: None, Conflict of Interest: None
DOI: 10.4103/UROS.UROS_148_21
Purpose: The aim was to assess the results of balloon dilation in patients with bladder neck contracture (BNC) after endoscopic surgery for benign prostatic hyperplasia (BPH). Materials and Methods: The study involved 120 patients with recurrent BNC after transurethral interventions for BPH. All patients underwent transurethral resection (TUR) of the bladder neck and were divided into two groups: Group A (n = 45) included men who, after TUR, additionally underwent repeated balloon dilation, whereas the control group B (n = 75) included men who were treated with alpha-blockers alone. Results: In 9 months after TUR and 3 months after the 4th balloon dilation procedure in Group A, the mean international prostate symptom score (IPSS) decreased from 20.1 ± 8.4 to 17.2 ± 7.4, and the IPSS-quality of life was 4.2 ± 1.2 (P > 0.05). In Group B, they were 21.7 ± 7.7 and 4.7 ± 1.1 (P > 0.05), respectively. In addition, the mean flow rate in Group A was 13.2 ± 5.4 ml/s, whereas in Group B, it was 8.7 ± 4.9 ml/s (P < 0.05). There was a significant decrease in the postvoid residual urine volume from 76.2 ± 96.1 ml to 37.6 ± 55.1 ml in Group A, whereas, in Group B, it increased from 63.0 ± 36.9 ml to 79.4 ± 71.6 ml (P > 0.05). Furthermore, 28.0% of patients of Group B and 13.3% of patients of Group A underwent repeated TUR of the bladder neck in 9 months follow-up period (P < 0.05). Conclusion: Balloon dilation is a safe less invasive procedure and can reduce the possibility of BNC recurrence and thus the rate of repeated transurethral interventions.
Keywords: Balloon dilation, benign prostatic hyperplasia, bladder neck contracture, transrectal ultrasound
Transurethral resection of the prostate (TURP) and endoscopic enucleation is currently considered the most effective,[1],[2],[3],[4],[5],[6] mastered, and available standards of surgical correction of bladder outlet obstruction.[7] The operation has been used in clinical practice for more than 50 years and is recognized as an effective, relatively safe method of treating patients with benign prostatic hyperplasia (BPH) of medium size and is accompanied by a small number of such short-term postoperative complications as minor bleeding (is observed in approximately 1.7% to 8.2% of cases), and TUR syndrome (occurs in up to 1.1% of cases) and a short length of hospital stay.[4],[8] Nevertheless, the long-term sclerotic changes in the bladder neck that occur after endoscopic procedures on the prostate require repeated surgical interventions, which significantly reduce the quality of life (QoL) of patients and negatively affect the state of the male genitourinary system as a whole.
It should be noted that with TURP performed in a small volume of BPH, complications occur in 15% of cases and include bleeding, urethral stricture (which is detected in 2.2%–9.8% of cases), and subsequent sclerosis (ranging from 0.3% to 9.1% of cases).[9],[10],[11] One of the reasons for the fibrosis the formation is the extended resection of tissues in the bladder neck, which can be the cause of narrowing or deformity.[12],[13]
The treatment of sclerosis is a difficult task,[14] even for experienced urologists, as often several interventions have to be performed to correct the bladder outlet obstruction.[15] As a rule, the following endoscopic methods are used: dilation, image-guided urethrotomy, and bladder neck resection. After such interventions, urinary incontinence is common, which worsens the QoL of patients.[16],[17],[18]
Currently, there is no consensus among urologists regarding which method is advisable for postoperative stricture of the posterior urethra/bladder neck (bladder neck contracture [BNC]): TUR or incision. Therefore, we aimed to assess the results of transurethral balloon dilation of the bladder neck in patients with recurrent BNC after endoscopic surgeries for BPH.
Materials and MethodsStudy design
This prospective, single-center study was approved by the Medical Research and Educational Centre of Lomonosov Moscow State University (MREC) (№ 1/21 from January 25, 2019), which was conducted following the Declaration of Helsinki and the Good Clinical Practice guidelines. All patients signed appropriate information consent.
Patients
The criteria for the inclusion of patients in the study were the presence of BNC formed after TURP and endoscopic enucleation of the BPH. Patients who underwent surgeries for malignant neoplasms of the prostate and with post-traumatic, post-inflammatory urethral strictures were excluded from the study. All patients, in addition to routine clinical and laboratory studies, underwent uroflowmetry before surgery, and the volume of residual urine (postvoid residual [PVR]) was also measured. Transrectal ultrasonography (TRUS) of the prostate was performed. Narrowing (sclerosis) of the bladder neck was confirmed by urethrocystoscopy [Figure 1].
Intervention technique
Balloon dilation technique
To assess the condition of the bladder neck before balloon dilation, prostate TRUS was performed, and the condition of the prostate was assessed by visualizing it in a longitudinal and cross-section. For the transrectal ultrasound diagnostic system, Epiq 7 (Philips, Netherlands) with an intracavitary probe (4–10 MHz) was utilized. The length of the bed of the removed BPH, the anteroposterior dimension in the widest part, the bilateral dimension in the widest part, the volume of the defect, and the anteroposterior dimension of the bladder neck were measured [Figure 2].
Figure 2: Transrectal ultrasonography picture of the prostate and bed of the removed benign prostatic hyperplasia: (a) Longitudinal section, (b) cross-sectionAfter the introduction of Cathejell® with Lidocaine 12.5 g. anesthetic gel into the urethra, a balloon-type urethral catheter (3 way Dufour Rusch® Softsimplastic, Ireland) with an increased capacity was inserted through the urethra into the lumen of the bladder. The best approach, in our opinion, for this procedure is an 18 Fr balloon catheter, the diameter of which allows it to pass through the narrowed part of the urethra and the elasticity of which is sufficient to dilate the fibrotic ring of the bladder neck. Balloon dilation was performed with a bladder volume of at least 150 ml.
Under TRUS control, the balloon of the urethral catheter was placed into the lumen of the bladder neck so that the widest part of the balloon was localized in the area of the fibrotic ring of the bladder neck and inflated to a size slightly larger than the diameter of the bed of the removed BPH so that the walls of the balloon exerted pressure on the fibrotic ring [Figure 3]. The balloon was left in this position for 5 min, during which, due to the property of elasticity, the balloon tended to take the shape characteristic of the inflated state and eliminate the compression, due to which gentle elastic stretching and tearing of the fibrotic ring of the bladder neck occurred. Next, a similar manipulation was performed by moving the balloon to the bed of the removed BPH [Figure 2]. Then the balloon was completely deflated and catheter was removed from the bladder cavity. The approximate procedure duration was 15–20 min.
Figure 3: Transrectal ultrasonography guided balloon dilation procedure (arrow – balloon of the catheter located in the area of the bladder neck fibrotic ring): (a) After the inflation of the balloon (5 ml), (b) After the 5-min expositionTo evaluate the results of the performed procedure, the measurements of the length of the removed BPH bed, the anteroposterior size in the widest part, the bilateral size in the widest part, the anteroposterior size, and the volume of the bladder neck defect were repeated. The results of both of these measurements reflect the state of the neck before and after the manipulation, that is, they visualize the dilating effect of the procedure. This study allowed us to assess the individual dynamics of the functional state of the bladder neck according to the above indicators. After the completion of the manipulation, uroflowmetry was performed to control the urodynamic status of the patient.
Balloon dilation was performed in several sessions until the desired effect was obtained, and the results of stretching the bladder neck were consolidated. The patient underwent repeated balloon dilation interventions in 1, 2, 3, and 6 months after TUR of the bladder neck.
Statistical analysis
Statistical data were analyzed using MS Excel 2019 (Microsoft Corp., WA, USA) and IBM SPSS© Statistics 21.0 statistical packages (IBM Corp., Armonk, NY, USA). The analysis of the obtained values distribution normality was carried out according to the one-sample Kolmogorov − Smirnov Z criterion. When a distribution is normal, the mean values for the groups are presented as a sample mean value and standard deviation – M (S), and when it differs from normal, as a median with 25%–75% quartiles. The significance of differences between groups is calculated using Student's t-tests for means, Mann-Whitney, and Wilcoxon for medians and ranks; differences are considered significant at P < 0.05.
ResultsPatients and treatment
This study involved 120 patients with recurrent BNC developed after TURP and laser enucleation underwent TUR of the bladder neck using electro-(bipolar) and laser energy during the period from April 2019 to August 2020 at the MREC. After the intervention, the patients were divided into two groups: group A (n = 45) included men who additionally underwent transurethral balloon dilation after TUR of the bladder neck, whereas control group B (n = 75) included men who received conservative therapy alone with alpha-blockers (tamsulosin 0.4 mg/day).
The main baseline clinical and anamnestic characteristics of the patients are shown in [Table 1].
Clinical outcome
In 1 month after the 1st balloon dilation procedure, the main parameters (uroflowmetry, PVR, international prostate symptom score [IPSS], IPSS-QoL) of the patients of group A improved significantly (P < 0.05 for all). There was a statistically significant difference between groups after treatment in all parameters, except for IPSS [Table 2], i.e., in patients of Group A, these parameters were significantly better.
Table 2: Dynamics of some parameters in the groups after balloon dilation of the bladder neck (n=120)However, a slight worsening of the studied parameters was observed in Group A beginning from 3 months after the TUR and this tendency saved till the end of the follow-up. However, in comparison with the parameters of patient of the Group B given worsening was not so significant. Significant deterioration in 3 months after TURP developed in 4 (8.8%) patients in Group A, whereas in Group B, deterioration was observed in 12 (16%) patients (P < 0.05). This indicator was 20% (9 patients) and 35% (26 patients) in Groups A and B after 9 months, respectively (P < 0.05).
In 9 months after TURP of the bladder neck and 3 months after the 4th balloon dilation, the average maximum urine flow rate in Group A was 13.2 ± 5.4 ml/s, whereas in Group B, this parameter was 8.7 ± 4.9 ml/s. Furthermore, in Group A, a significant decrease in the PVR was revealed-from 76.2 ± 96.10 to 37.6 ± 55.1 ml, and in Group B, this indicator decreased from 63.0 ± 36.9 to 79.4 ± 71.6 ml [Table 2].
During the follow-up period, recurrence of BNC developed in 27 patients (22.5%) of both groups. All of them underwent repeated TUR of the bladder neck. In eight patients (7 from Group B and 1 from Group A), recurrence was observed in 3 months after TUR. In 12 patients (9 from Group B and 3 from Group A) recurrence developed after 6 months, whereas in 7 patients (5 from Group B and 2 from Group A) BNC recurred after 9 months. The main parameters of the patients with BNC recurrence are given in [Table 3].
Table 3: Parameters in the groups after balloon dilation of the bladder neck, who had a recurrence (n=120)Adverse events and complication rates
Balloon dilation procedures were accompanied by a less amount of light to moderate complications. Acute urinary retention developed only in 1 (2.2%) case, which was resolved with indwelling catheterization for 48 h. In 2 (4.4%) patients, acute orchiepididymitis was observed and treated successfully with antibacterial drugs. In 14 (31.1%) men in Group A, haematuria was determined, which did not require the use of hemostatic drugs and was not accompanied by a decrease in hemoglobin in the peripheral blood, in 4 (8.8%) patients' short-term urethrorrhagia occurred which resolved without additional therapy. Dysuria was observed in 8 (17.8%) patients, which resolved without treatment. There were no severe surgical complications in Group A according to the Clavien–Dindo scoring system that required repeated intervention during the 90-day postoperative period.
DiscussionDespite the fact that, in recent years, new endoscopic methods of treatment of patients with BPH have been developed and introduced into practice, including bipolar resection (B-TURP) and laser enucleation, the complications' rate after these surgical interventions remains quite high, including the urethral strictures (2.2%–9.8%) and BNC (0.3%–9.2%).[16] Contracture of the bladder neck significantly worsens the long-term results of TURP and the QoL of patients, who often undergo repeated and painful surgical interventions without obtaining the desired result. Therefore, the treatment of this category of patients is a serious clinical problem, which is reflected in the fact that various methods of treatment are proposed, such as deep lateral incisions of the urethral wall using a cold knife or laser, bipolar vaporization of the bladder neck, an incision with an intravesical injection of mitomycin C and T-plasty, and finally, balloon dilation and reconstructive surgery.[19] However, all of these methods of treatment are associated with a significant frequency of relapses, and urologists continue to search for the best method, preferably minimally invasive, to eliminate postoperative BNC. In this light, a promising direction is the application of the balloon dilation technique, which is successfully used in practice as an alternative method of treating urethral strictures. To our knowledge, we are the first contributors to the evidence for this method application.
It is believed that sclerosis usually occurs after resections performed on the small prostate (<30 g) and that such sclerosis is a consequence of tissue ischemia.[9],[16] Therefore, the indications for performing TURP in cases of small prostate size should be treated very cautiously. In our study, the mean prostate size was also small (41.5 ± 9.3 g).
Steenkamp et al. studied the results of using dilation and internal urethrotomy as a treatment for postoperative urethral strictures. The authors did not find a significant difference in the effectiveness of the methods used; however, they emphasized that the procedures are less effective with an increase in the length of the stricture and recommend dilation or internal optical urethrotomy for strictures no more than 2 cm in length. In this observation, the recurrence rate 12 months after the intervention was approximately 40% in patients with urethral strictures less than 2 cm in length and 80% in patients with a length of 4 cm.[20] According to our results, the recurrence rate of BNC was 21,6% (27 out of 120) during 9 months follow-up.
Transurethral balloon dilation is easy to perform and less invasive than cold knife incision, and the advantage of balloon dilation is the lower risk of urethral injury. The most frequent complications, which can occur in up to 20% of cases after urethrotomy, are perineal hematomas and bleeding from the urethra, which requires additional interventions.[20],[21] It is also should be noted that urinary incontinence is observed in 75% of cases.[19] No cases of urinary incontinence and perineal hematomas were revealed during our study.
The most expedient, easily feasible, and affordable way of eliminating postoperative bladder outlet obstruction is the use of a special catheter with a balloon that allows an increase in the lumen of the urethra.[22] However, the conditions for using this method in the treatment of patients with BNC are the presence of a preserved lumen and the absence of extended urethral strictures. Therefore, when using this method, before the operation, all patients undergo urethrography and urethroscopy to determine the state of the urethra and bladder and the possibility of using balloon dilation. Dilation is usually fast, gives immediate results, and is technically relatively easy to manipulate. It should be noted that dilation involves sequential stretching rather than rupture of the stricture tissue.
There are a lot of reports dedicated to endoscopic balloon dilation of bladder neck in the area of vesicourethral anastomosis after radical prostatectomy.[23] Park et al. reported about 93% of success in 24 patients during at least 12 months.[24] Transurethral balloon dilation also was performed by Ramchandani et al. in patients with postoperative stricture of the prostatic urethra after radical prostatectomy and was successful in 59% (mean, 31.5 months 7 years to 12 months) of cases; the rest of the patients underwent transurethral dissection of the bladder neck. Later, however, these men required a redo of balloon dilation. The author noted that urinary incontinence was found only in one patient who underwent incision of the bladder neck, and no case of incontinence was found in those who underwent balloon dilation.[25] According to our data, the treatment success rate was 87% during 9 month period and no cases of urinary incontinence were observed.
However, Ramchandani used a “low” pressure cylinder. Ishii used a high-pressure urethral balloon catheter (up to 30 atm) to treat patients with postoperative strictures, which provided a sufficient increase in its volume and led to dilation of the narrowing. It is not clear at this time whether the higher pressure in the balloon is a positive factor and the expansion is more efficient than using a “regular” balloon. However, on the positive side, forces are applied radially to expand the stricture while avoiding the potentially traumatic moments associated with sequential rigid dilation. The use of this method made it possible to achieve positive results in 80% of cases.[26] We also used a high-pressure urethral catheter (up to 4.9 atm), which made it possible to overcome the resistance of the scar tissue of the bladder neck.
Gelman et al. reported that they applied dilation using a rigid cystoscope, and the position of the balloon was visually monitored. The authors believe that because the procedure is performed with direct imaging, it is more controllable than using wires and avoids false path formation. However, the intervention requires general or spinal anesthesia, and after surgery, there is a need for hospitalization of the patient.[27] The balloon dilation technique we proposed can be performed under TRUS guidance using local anesthetics on an outpatient basis.
Therefore, Vyas et al. retrospectively studied the results of balloon dilation performed in patients with urethral strictures after endoscopic and traditional operations. Patients with stricture lengths less than 1.5 cm were treated under X-ray control. A balloon catheter (Cook Urological, Spencer, Indiana) was inserted into the urethra through a metal guide and pressurized in the balloon until the waist disappeared. It should be noted that we also focused on balloon deformation; however, we performed dilation in two areas, while the abovementioned authors used balloon dilation in one position. After the intervention, the bladder was drained using a urethral catheter, as in our case. The stricture was eliminated in 68.3% of patients.[28]
Xie et al. used balloon dilation of urethral strictures under ultrasonographic control. The operation was performed successfully in all patients without any major complications. The urethral catheter was removed 3–4 weeks after surgery. However, the method was used in the treatment of 5 patients with urethral strictures; nevertheless, the authors achieved good results, and the effectiveness of the operation was assessed using urethrocystoscopy.[29] We also used ultrasonography for balloon dilation, whereby we measured the length of the bed of the removed prostate, the anteroposterior dimension in the widest part, the bilateral dimension in the widest part, the volume of the defect, and the anteroposterior dimension of the bladder neck. After dilation, the effectiveness of the manipulation was assessed by the comparison method.
Our study has certain limitations such as the small size of the sample with patients who underwent balloon dilation and the short follow-up period. Nevertheless, the findings are statistically significant, which suggests that they can be extrapolated to the general sample of patients with BNC. Balloon dilation is a promising less invasive procedure that can be applied on an outpatient basis. Of course, further large-scale and well-organized studies are needed to confirm or reject the clinical value of this treatment method.
ConclusionTRUS-guided transurethral balloon dilation of BNC using local anesthesia is a relatively safe and less invasive method that helped to avoid gross trauma to the urethra and bladder neck with a cystoscope and reduced the likelihood and severity of complications of this treatment method. This method can be used as an alternative for other routine treatment methods such as transurethral incisions or resections.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
References
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