Effect of statins on abdominal aortic aneurysm

Elsevier

Available online 26 August 2022, 106284

European Journal of Pharmaceutical SciencesAbstract

Abdominal aortic aneurysm (AAA) is a prevalent condition which causes progressive growth and rupture of aortic wall with a high death rate. Several studies have found that treatment with statins may decrease the progress of AAA and the risk of rupture by suppressing the inflammatory mediators, decreasing oxidative stress, and inhibiting mechanisms involved in extracellular matrix (ECM) degradation. Moreover, some studies have reported that prehospital therapy with statins can decrease mortality after surgery. The novelty of this paper is that different studies including those performed in humans and animals were reviewed and the potential mechanisms by which statins can have an effect on AAA were summarized. Overall, the evidence suggested an association between treatment with statins and improvement of AAA.

Keywords

Abdominal aortic aneurysm

Statins

Inflammation

Oxidative stress

Extracellular matrix

Data Availability

No data was used for the research described in the article.

© 2022 The Author(s). Published by Elsevier B.V.

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