A deep learning model with incorporation of microvascular invasion area as a factor in predicting prognosis of hepatocellular carcinoma after R0 hepatectomy

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424

PubMed  Article  Google Scholar 

Marrero JA, Kulik LM, Sirlin CB, Zhu AX, Finn RS, Abecassis MM, et al. Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2018;68(2):723–750

Article  PubMed  Google Scholar 

European Association for the Study of the Liver. Electronic address eee, European Association for the Study of the L: EASL Clinical Practice Guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182–236

Article  Google Scholar 

Xie DY, Ren ZG, Zhou J, Fan J, Gao Q. 2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights. Hepatobil Surg Nutr. 2020;9(4):452–463

Article  Google Scholar 

Grazi GL, Ercolani G, Pierangeli F, Del Gaudio M, Cescon M, Cavallari A, et al. Improved results of liver resection for hepatocellular carcinoma on cirrhosis give the procedure added value. Ann Surg. 2001;234(1):71–78

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lim KC, Chow PK, Allen JC, Siddiqui FJ, Chan ES, Tan SB. Systematic review of outcomes of liver resection for early hepatocellular carcinoma within the Milan criteria. Br J Surg. 2012;99(12):1622–1629

PubMed  Article  Google Scholar 

Zhang X, Li J, Shen F, Lau WY. Significance of presence of microvascular invasion in specimens obtained after surgical treatment of hepatocellular carcinoma. J Gastroenterol Hepatol. 2018;33(2):347–354

PubMed  Article  Google Scholar 

Cong WM, Bu H, Chen J, Dong H, Zhu YY, Feng LH, et al. Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update. World J Gastroenterol. 2016;22(42):9279–9287

PubMed  PubMed Central  Article  Google Scholar 

Roayaie S, Blume IN, Thung SN, Guido M, Fiel MI, Hiotis S, et al. A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma. Gastroenterology. 2009;137(3):850–855

PubMed  Article  Google Scholar 

Xiang YJ, Wang K, Zheng YT, Yu HM, Cheng YQ, Wang WJ, et al. Prognostic value of microvascular invasion in eight existing staging systems for hepatocellular carcinoma: a bi-centeric retrospective cohort study. Front Oncol. 2021;11: 726569

PubMed  PubMed Central  Article  Google Scholar 

Lim KC, Chow PK, Allen JC, Chia GS, Lim M, Cheow PC, et al. Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria. Ann Surg. 2011;254(1):108–113

PubMed  Article  Google Scholar 

Chen ZH, Zhang XP, Feng JK, Li LQ, Zhang F, Hu YR, et al. Actual long-term survival in hepatocellular carcinoma patients with microvascular invasion: a multicenter study from China. Hepatol Int. 2021;15(3):642–650

PubMed  Article  Google Scholar 

Sumie S, Nakashima O, Okuda K, Kuromatsu R, Kawaguchi A, Nakano M, et al. The significance of classifying microvascular invasion in patients with hepatocellular carcinoma. Ann Surg Oncol. 2013;21(3):1002–1009

PubMed  Article  Google Scholar 

Feng LH, Dong H, Lau WY, Yu H, Zhu YY, Zhao Y, et al. Novel microvascular invasion-based prognostic nomograms to predict survival outcomes in patients after R0 resection for hepatocellular carcinoma. J Cancer Res Clin Oncol. 2017;143(2):293–303

PubMed  Article  Google Scholar 

Tateishi R, Yoshida H, Shiina S, Imamura H, Hasegawa K, Teratani T, et al. Proposal of a new prognostic model for hepatocellular carcinoma: an analysis of 403 patients. Gut. 2005;54(3):419–425

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kudo M, Chung H, Osaki Y. Prognostic staging system for hepatocellular carcinoma (CLIP score): its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score). J Gastroenterol. 2003;38(3):207–215

PubMed  Article  Google Scholar 

Chevret S, Trinchet J-C, Mathieu D, Rached AA, Beaugrand M, Chastang C. A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. J Hepatol. 1999;31(1):133–141

CAS  PubMed  Article  Google Scholar 

Hsu CY, Huang YH, Hsia CY, Su CW, Lin HC, Loong CC, et al. A new prognostic model for hepatocellular carcinoma based on total tumor volume: the Taipei Integrated Scoring System. J Hepatol. 2010;53(1):108–117

PubMed  Article  Google Scholar 

Okuda K, Obata H, Nakajima Y, Ohtsuki T, Okazaki N, Ohnishi K. Prognosis of primary hepatocellular carcinoma. Hepatology. 1984;4(1 Suppl):3S-6S

CAS  PubMed  Article  Google Scholar 

Amin MBES, Greene F, Byrd DR, Brookland RK, Washington MK, et al. AJCC cancer staging manual. 8th ed. New York: Springer Nature; 2017

Book  Google Scholar 

Yau T, Tang VY, Yao TJ, Fan ST, Lo CM, Poon RT. Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma. Gastroenterology. 2014;146(7):1691-1700e1693

PubMed  Article  Google Scholar 

Liang W, Yao J, Chen A, Lv Q, Zanin M, Liu J, et al. Early triage of critically ill COVID-19 patients using deep learning. Nat Commun. 2020;11(1):3543

CAS  PubMed  PubMed Central  Article  Google Scholar 

Cheng NM, Yao J, Cai J, Ye X, Zhao S, Zhao K, et al. Deep learning for fully automated prediction of overall survival in patients with oropharyngeal cancer using FDG-PET imaging. Clin Cancer Res. 2021;27(14):3948–3959

CAS  PubMed  Article  Google Scholar 

Zhang XP, Wang K, Wei XB, Li LQ, Sun HC, Wen TF, et al. An Eastern Hepatobiliary Surgery Hospital microvascular invasion scoring system in predicting prognosis of patients with hepatocellular carcinoma and microvascular invasion after R0 liver resection: a large-scale, multicenter study. Oncologist. 2019;24(12):e1476–e1488

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sun JJ, Wang K, Zhang CZ, Guo WX, Shi J, Cong WM, et al. Postoperative adjuvant transcatheter arterial chemoembolization after R0 hepatectomy improves outcomes of patients who have hepatocellular carcinoma with microvascular invasion. Ann Surg Oncol. 2016;23(4):1344–1351

PubMed  Article  Google Scholar 

Shi M, Guo RP, Lin XJ, Zhang YQ, Chen MS, Zhang CQ, et al. Partial hepatectomy with wide versus narrow resection margin for solitary hepatocellular carcinoma: a prospective randomized trial. Ann Surg. 2007;245(1):36–43

PubMed  PubMed Central  Article  Google Scholar 

Zhang YF, Zhou J, Wei W, Zou RH, Chen MS, Lau WY, et al. Intermediate-stage hepatocellular carcinoma treated with hepatic resection: the NSP score as an aid to decision-making. Br J Cancer. 2016;115(9):1039–1047

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ching T, Zhu X, Garmire LX. Cox-nnet: An artificial neural network method for prognosis prediction of high-throughput omics data. PLoS Comput Biol. 2018;14(4): e1006076

PubMed  PubMed Central  Article  CAS  Google Scholar 

Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, et al. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol. 2003;38(2):200–207

PubMed  Article  Google Scholar 

Erstad DJ, Tanabe KK. Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma. Ann Surg Oncol. 2019;26(5):1474–1493

PubMed  Article  Google Scholar 

Wang MD, Li C, Liang L, Xing H, Sun LY, Quan B, et al. Early and late recurrence of hepatitis B virus-associated hepatocellular carcinoma. Oncologist. 2020;25(10):e1541–e1551

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shindoh J, Kobayashi Y, Kawamura Y, Akuta N, Kobayashi M, Suzuki Y, et al. Microvascular invasion and a size cutoff value of 2 cm predict long-term oncological outcome in multiple hepatocellular carcinoma: reappraisal of the American Joint Committee on cancer staging system and validation using the surveillance, epidemiology, and end-results database. Liver Cancer. 2020;9(2):156–166

PubMed  Article  Google Scholar 

Wang L, Wang W, Yao X, Rong W, Wu F, Chen B, et al. Postoperative adjuvant radiotherapy is associated with improved survival in hepatocellular carcinoma with microvascular invasion. Oncotarget. 2017;8(45):79971–79981

PubMed  PubMed Central  Article  Google Scholar 

Hirokawa F, Hayashi M, Miyamoto Y, Asakuma M, Shimizu T, Komeda K, et al. Outcomes and predictors of microvascular invasion of solitary hepatocellular carcinoma. Hepatol Res. 2014;44(8):846–853

CAS  PubMed  Article  Google Scholar 

Shi C, Zhao Q, Liao B, Dong Z, Wang C, Yang J, et al. Anatomic resection and wide resection margin play an important role in hepatectomy for hepatocellular carcinoma with peritumoural micrometastasis. ANZ J Surg. 2019;89(11):E482–E486

PubMed  Article  Google Scholar 

Hidaka M, Eguchi S, Okuda K, Beppu T, Shirabe K, Kondo K, et al. Impact of anatomical resection for hepatocellular carcinoma with microportal invasion (vp1): a multi-institutional study by the Kyushu Study Group of liver surgery. Ann Surg. 2020;271(2):339–346

PubMed  Article  Google Scholar 

Shi C, Li Y, Geng L, Shen W, Sui C, Dai B, et al. Adjuvant stereotactic body radiotherapy after marginal resection for hepatocellular carcinoma with microvascular invasion: a randomised controlled trial. Eur J Cancer. 2022;166:176–184

CAS  PubMed  Article 

留言 (0)

沒有登入
gif