Bernstein, B. E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315–326 (2006).
CAS Article PubMed Google Scholar
Piunti, A. & Shilatifard, A. Epigenetic balance of gene expression by Polycomb and COMPASS families. Science 352, aad9780 (2016).
Article CAS PubMed Google Scholar
Azuara, V. et al. Chromatin signatures of pluripotent cell lines. Nat. Cell Biol. 8, 532–538 (2006).
CAS Article PubMed Google Scholar
Mikkelsen, T. S. et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448, 553–560 (2007).
CAS PubMed Central Article PubMed Google Scholar
Zhao, X. D. et al. Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 1, 286–298 (2007).
CAS Article PubMed Google Scholar
Pan, G. et al. Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell 1, 299–312 (2007).
CAS Article PubMed Google Scholar
Rugg-Gunn, P. J., Cox, B. J., Ralston, A. & Rossant, J. Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc. Natl Acad. Sci. USA 107, 10783–10790 (2010).
CAS PubMed Central Article PubMed Google Scholar
Zheng, H. et al. Resetting epigenetic memory by reprogramming of histone modifications in mammals. Mol. Cell 63, 1066–1079 (2016).
CAS Article PubMed Google Scholar
Xiang, Y. et al. Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency. Nat. Genet. 52, 95–105 (2020).
CAS Article PubMed Google Scholar
Liu, X. et al. Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos. Nature 537, 558–562 (2016).
CAS Article PubMed Google Scholar
Sachs, M. et al. Bivalent chromatin marks developmental regulatory genes in the mouse embryonic germline in vivo. Cell Rep. 3, 1777–1784 (2013).
CAS PubMed Central Article PubMed Google Scholar
Ng, J.-H. et al. In vivo epigenomic profiling of germ cells reveals germ cell molecular signatures. Dev. Cell 24, 324–333 (2013).
CAS Article PubMed Google Scholar
Lesch, B. J., Dokshin, G. A., Young, R. A., McCarrey, J. R. & Page, D. C. A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. Proc. Natl Acad. Sci. USA 110, 16061–16066 (2013).
CAS PubMed Central Article PubMed Google Scholar
Mu, W., Starmer, J., Fedoriw, A. M., Yee, D. & Magnuson, T. Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development. Gene Dev. 28, 2056–2069 (2014).
CAS PubMed Central Article PubMed Google Scholar
Roh, T.-Y., Cuddapah, S., Cui, K. & Zhao, K. The genomic landscape of histone modifications in human T cells. Proc. Natl Acad. Sci. USA 103, 15782–15787 (2006).
CAS PubMed Central Article PubMed Google Scholar
Barski, A. et al. High-resolution profiling of histone methylations in the human genome. Cell 129, 823–837 (2007).
CAS Article PubMed Google Scholar
Voigt, P. et al. Asymmetrically modified nucleosomes. Cell 151, 181–193 (2012).
CAS PubMed Central Article PubMed Google Scholar
Sen, S., Block, K. F., Pasini, A., Baylin, S. B. & Easwaran, H. Genome-wide positioning of bivalent mononucleosomes. BMC Med. Genomics 9, 60 (2016).
PubMed Central Article CAS PubMed Google Scholar
Voigt, P., Tee, W.-W. & Reinberg, D. A double take on bivalent promoters. Gene Dev. 27, 1318–1338 (2013).
CAS PubMed Central Article PubMed Google Scholar
Lesch, B. J., Silber, S. J., McCarrey, J. R. & Page, D. C. Parallel evolution of male germline epigenetic poising and somatic development in animals. Nat. Genet. 48, 888–894 (2016).
CAS Article PubMed Google Scholar
Dattani, A. et al. Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone modifications in animal stem cells. Genome Res. 28, 1543–1554 (2018).
CAS PubMed Central Article PubMed Google Scholar
Vastenhouw, N. L. et al. Chromatin signature of embryonic pluripotency is established during genome activation. Nature 464, 922–926 (2010).
CAS PubMed Central Article PubMed Google Scholar
Kang, H. et al. Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes in Drosophila. Gene Dev. 31, 1988–2002 (2017).
CAS PubMed Central Article PubMed Google Scholar
Schertel, C. et al. A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development. Genome Res. 25, 514–523 (2015).
CAS PubMed Central Article PubMed Google Scholar
Akmammedov, A., Geigges, M. & Paro, R. Bivalency in Drosophila embryos is associated with strong inducibility of Polycomb target genes. Fly 13, 42–50 (2019).
PubMed Central Article PubMed Google Scholar
Akkers, R. C. et al. A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in xenopus embryos. Dev. Cell 17, 425–434 (2009).
CAS PubMed Central Article PubMed Google Scholar
Yu, J.-R., Lee, C.-H., Oksuz, O., Stafford, J. M. & Reinberg, D. PRC2 is high maintenance. Gene Dev. 33, 903–935 (2019).
CAS PubMed Central Article PubMed Google Scholar
Schuettengruber, B., Bourbon, H.-M., Croce, L. D. & Cavalli, G. Genome regulation by polycomb and trithorax: 70 years and counting. Cell 171, 34–57 (2017).
CAS Article PubMed Google Scholar
Cenik, B. K. & Shilatifard, A. COMPASS and SWI/SNF complexes in development and disease. Nat. Rev. Genet. 22, 38–58 (2021).
CAS Article PubMed Google Scholar
Piunti, A. & Shilatifard, A. The roles of Polycomb repressive complexes in mammalian development and cancer. Nat. Rev. Mol. Cell Biol. 22, 326–345 (2021).
CAS Article PubMed Google Scholar
Blackledge, N. P. & Klose, R. J. The molecular principles of gene regulation by Polycomb repressive complexes. Nat. Rev. Mol. Cell Biol. 22, 815–833 (2021).
CAS PubMed Central Article PubMed Google Scholar
Denissov, S. et al. Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant. Development 141, 526–537 (2014).
CAS Article PubMed Google Scholar
Hu, D. et al. Not All H3K4 methylations are created equal: Mll2/COMPASS dependency in primordial germ cell specification. Mol. Cell 65, 460–475.e6 (2017).
CAS PubMed Central Article PubMed Google Scholar
Hu, D. et al. The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells. Nat. Struct. Mol. Biol. 20, 1093–1097 (2013).
CAS PubMed Central Article PubMed Google Scholar
Mas, G. et al. Promoter bivalency favors an open chromatin architecture in embryonic stem cells. Nat. Genet. 50, 1452–1462 (2018).
CAS Article PubMed Google Scholar
Sze, C. C. et al. Coordinated regulation of cellular identity–associated H3K4me3 breadth by the COMPASS family. Sci. Adv. 6, eaaz4764 (2020).
CAS PubMed Central Article PubMed Google Scholar
Douillet, D. et al. Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation. Nat. Genet. 52, 615–625 (2020).
留言 (0)