Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424

PubMed  Google Scholar 

Waks AG, Winer EP (2019) Breast cancer treatment: a review. JAMA 321(3):288–300

CAS  PubMed  Article  Google Scholar 

Kramer S, Darsow M, Kummel S, Kimmig R, Rezai M (2008) Breast-conserving treatment of breast cancer–oncological and reconstructive aspects. Gynakol Geburtshilfliche Rundsch 48(2):56–62

PubMed  Article  Google Scholar 

Schwartz GF, Veronesi U, Clough KB, Dixon JM, Fentiman IS, Heywang-Kobrunner SH, Holland R, Hughes KS, Mansel RE (2006) Margolese R and others Consensus conference on breast conservation. J Am Coll Surg 203(2):198–207

PubMed  Article  Google Scholar 

Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N (2002) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347(16):1233–1241

PubMed  Article  Google Scholar 

Kreike B, Hart AA, van de Velde T, Borger J, Peterse H, Rutgers E, Bartelink H, van de Vijver MJ (2008) Continuing risk of ipsilateral breast relapse after breast-conserving therapy at long-term follow-up. Int J Radiat Oncol Biol Phys 71(4):1014–1021

PubMed  Article  Google Scholar 

Komoike Y, Akiyama F, Iino Y, Ikeda T, Akashi-Tanaka S, Ohsumi S, Kusama M, Sano M, Shin E, Suemasu K et al (2006) Ipsilateral breast tumor recurrence IBTR after breast-conserving treatment for early breast cancer: risk factors and impact on distant metastases. Cancer 106(1):35–41

PubMed  Article  Google Scholar 

Nottage MK, Kopciuk KA, Tzontcheva A, Andrulis IL, Bull SB, Blackstein ME (2006) Analysis of incidence and prognostic factors for ipsilateral breast tumour recurrence and its impact on disease-specific survival of women with node-negative breast cancer: a prospective cohort study. Breast Cancer Res 8(4):R44

PubMed  PubMed Central  Article  Google Scholar 

Bijker N, Peterse JL, Duchateau L, Julien JP, Fentiman IS, Duval C, Di Palma S, Simony-Lafontaine J, de Mascarel I, van de Vijver MJ (2001) Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma-in-situ: analysis of European Organization for Research and Treatment of Cancer Trial 10853. J Clin Oncol 19(8):2263–2271

CAS  PubMed  Article  Google Scholar 

Park CC, Mitsumori M, Nixon A, Recht A, Connolly J, Gelman R, Silver B, Hetelekidis S, Abner A, Harris JR et al (2000) Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence. J Clin Oncol 18(8):1668–75

Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans V, Godwin J, Gray R, Hicks C, James S et al (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366(9503):2087–106

CAS  PubMed  Article  Google Scholar 

Brouwer de Koning SG, VranckenPeeters M, Jozwiak K, Bhairosing PA, Ruers TJM (2018) Tumor resection margin definitions in breast-conserving surgery: systematic review and meta-analysis of the current literature. Clin Breast Cancer 18(4):e595–e600

PubMed  Article  Google Scholar 

Chagpar AB, Killelea BK, Tsangaris TN, Butler M, Stavris K, Li F, Yao X, Bossuyt V, Harigopal M, Lannin DR et al (2015) A randomized, controlled trial of cavity shave margins in breast cancer. N Engl J Med 373(6):503–10

CAS  PubMed  PubMed Central  Article  Google Scholar 

McCahill LE, Single RM, Aiello Bowles EJ, Feigelson HS, James TA, Barney T, Engel JM, Onitilo AA (2012) Variability in reexcision following breast conservation surgery. JAMA 307(5):467–475

PubMed  Article  Google Scholar 

Pleijhuis RG, Graafland M, de Vries J, Bart J, de Jong JS, van Dam GM (2009) Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions. Ann Surg Oncol 16(10):2717–2730

PubMed  PubMed Central  Article  Google Scholar 

Bartelink H, Maingon P, Poortmans P, Weltens C, Fourquet A, Jager J, Schinagl D, Oei B, Rodenhuis C, Horiot JC et al (2015) Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. Lancet Oncol 16(1):47–56

PubMed  Article  Google Scholar 

Grant Y, Al-Khudairi R, St John E, Barschkett M, Cunningham D, Al-Mufti R, Hogben K, Thiruchelvam P, Hadjiminas DJ, Darzi A et al (2019) Patient-level costs in margin re-excision for breast-conserving surgery. Br J Surg 106(4):384–394

CAS  PubMed  Article  Google Scholar 

Vos EL, Siesling S, Baaijens MHA, Verhoef C, Jager A, Voogd AC, Koppert LB (2017) Omitting re-excision for focally positive margins after breast-conserving surgery does not impair disease-free and overall survival. Breast Cancer Res Treat 164(1):157–167

PubMed  PubMed Central  Article  Google Scholar 

Maloney BW, McClatchy DM, Pogue BW, Paulsen KD, Wells WA, Barth RJ (2018) Review of methods for intraoperative margin detection for breast conserving surgery. J Biomed Opt 23(10):1–19

PubMed  Article  Google Scholar 

Vahrmeijer AL, Hutteman M, van der Vorst JR, van de Velde CJ, Frangioni JV (2013) Image-guided cancer surgery using near-infrared fluorescence. Nat Rev Clin Oncol 10(9):507–518

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lamberts LE, Koch M, de Jong JS, Adams ALL, Glatz J, Kranendonk MEG, Terwisscha van Scheltinga AGT, Jansen L, de Vries J, Lub-de Hooge MN et al (2017) Tumor-specific uptake of fluorescent bevacizumab-IRDye800CW microdosing in patients with primary breast cancer: a phase I feasibility study. Clin Cancer Res 23(11):2730–2741

CAS  PubMed  Article  Google Scholar 

Voskuil FJ, Vonk J, van der Vegt B, Kruijff S, Ntziachristos V, van der Zaag PJ, Witjes MJH, van Dam GM (2022) Intraoperative imaging in pathology-assisted surgery. Nat Biomed Eng 6(5):503–514

PubMed  Article  Google Scholar 

Smith BL, Gadd MA, Lanahan CR, Rai U, Tang R, Rice-Stitt T, Merrill AL, Strasfeld DB, Ferrer JM, Brachtel EF et al (2018) Real-time, intraoperative detection of residual breast cancer in lumpectomy cavity walls using a novel cathepsin-activated fluorescent imaging system. Breast Cancer Res Treat 171(2):413–420

PubMed  PubMed Central  Article  Google Scholar 

Tang R, Coopey SB, Specht MC, Lei L, Gadd MA, Hughes KS, Brachtel EF, Smith BL (2015) Lumpectomy specimen margins are not reliable in predicting residual disease in breast conserving surgery. Am J Surg 210(1):93–98

PubMed  Article  Google Scholar 

Hernot S, van Manen L, Debie P, Mieog JSD, Vahrmeijer AL (2019) Latest developments in molecular tracers for fluorescence image-guided cancer surgery. Lancet Oncol 20(7):e354–e367

CAS  PubMed  Article  Google Scholar 

Tummers QR, Hoogstins CE, Gaarenstroom KN, de Kroon CD, van Poelgeest MI, Vuyk J, Bosse T, Smit VT, van de Velde CJ, Cohen AF et al (2016) Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17. Oncotarget 7(22):32144–55

PubMed  PubMed Central  Article  Google Scholar 

Dintzis SM, Hansen S, Harrington KM, Tan LC, Miller DM, Ishak L, Parrish-Novak J, Kittle D, Perry J, Gombotz C et al (2019) Real-time visualization of breast carcinoma in pathology specimens from patients receiving fluorescent tumor-Marking agent tozuleristide. Arch Pathol Lab Med 143(9):1076–1083

CAS  PubMed  Article  Google Scholar 

Unkart JT, Chen SL, Wapnir IL, Gonzalez JE, Harootunian A, Wallace AM (2017) Intraoperative tumor detection using a ratiometric activatable fluorescent peptide: a first-in-human phase 1 study. Ann Surg Oncol 24(11):3167–3173

PubMed  Article  Google Scholar 

Voskuil FJ, Steinkamp PJ, Zhao T, van der Vegt B, Koller M, Doff JJ, Jayalakshmi Y, Hartung JP, Gao J, Sumer BD et al (2020) Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery. Nat Commun 11(1):3257

CAS  PubMed  PubMed Central  Article  Google Scholar 

Olson OC, Joyce JA (2015) Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. Nat Rev Cancer 15(12):712–729

CAS  PubMed  Article  Google Scholar 

Reiser J, Adair B, Reinheckel T (2010) Specialized roles for cysteine cathepsins in health and disease. J Clin Invest 120(10):3421–3431

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fonovic M, Turk B (2014) Cysteine cathepsins and extracellular matrix degradation. Biochim Biophys Acta 1840(8):2560–2570

CAS  PubMed  Article  Google Scholar 

Brix K, Dunkhorst A, Mayer K, Jordans S (2008) Cysteine cathepsins: cellular roadmap to different functions. Biochimie 90(2):194–207

CAS  PubMed  Article  Google Scholar 

Vidak E, Javorsek U, Vizovisek M, Turk B (2019) Cysteine cathepsins and their extracellular roles: shaping the microenvironment. Cells 8(3)

Rudensky A, Beers C (2006) Lysosomal cysteine proteases and antigen presentation. Ernst Schering Res Found Workshop 56:81–95

Article  Google Scholar 

Turk B, Turk D, Turk V (2000) Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta 1477(1–2):98–111

CAS  PubMed  Article  Google Scholar 

Goulet B, Baruch A, Moon NS, Poirier M, Sansregret LL, Erickson A, Bogyo M, Nepveu A (2004) A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol Cell 14(2):207–219

CAS  PubMed  Article  Google Scholar 

Drake FH, Dodds RA, James IE, Connor JR, Debouck C, Richardson S, Lee-Rykaczewski E, Coleman L, Rieman D, Barthlow R et al (1996) Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem 271(21):12511–6

CAS  PubMed  Article  Google Scholar 

Nakagawa TY, Brissette WH, Lira PD, Griffiths RJ, Petrushova N, Stock J, McNeish JD, Eastman SE, Howard ED, Clarke SR et al (1999) Impaired invariant chain degradation and antigen presentation and dimin

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