Agrawal PK, Agrawal C, Blunden G (2021) Pharmacological significance of hesperidin and hesperetin, two citrus flavonoids, as promising antiviral compounds for prophylaxis against and combating COVID-19. Nat Prod Commun. https://doi.org/10.1177/1934578X211042540
Ahmadi A, Shadboorestan A, Nabavi S, Setzer W, Nabavi S (2015) The role of hesperidin in cell signal transduction pathway for the prevention or treatment of cancer. Curr Med Chem 22(30):3462–3471
CAS PubMed Article Google Scholar
Al-Mazaideh G, Al-Swailmi F, Parrey M (2021). Molecular docking study reveals naringenin and hesperetin from desert truffles as promising potential inhibitors for coronavirus (COVID-19) Medicinal impact of desert truffles. Ann Clin Anal Med pp. 980–985.
Alshatwi AA, Ramesh E, Periasamy V, Subash-Babu P (2013) The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways. Fundam Clin Pharmacol 27(6):581–592
CAS PubMed Article Google Scholar
Bellavite P, Donzelli A (2020) Hesperidin and SARS-CoV-2: new light on the healthy function of citrus fruits. Antioxidants 9(8):742
CAS PubMed Central Article Google Scholar
Cheke RS, Narkhede RR, Shinde SD, Ambhore JP, Jain PG (2021) Natural product emerging as potential SARS spike glycoproteins-ACE2 inhibitors to combat COVID-19 attributed by in-silico investigations. Biointerface Res Appl Chem 11:10628–10639
Cheng F-J, Huynh T-K, Yang C-S, Hu D-W, Shen Y-C, Tu C-Y, Chen Y (2021) Hesperidin is a potential inhibitor against SARS-CoV-2 infection. Nutrients 13(8):2800
CAS PubMed PubMed Central Article Google Scholar
Choi EM, Lee YS (2010) Effects of hesperetin on the production of inflammatory mediators in IL-1β treated human synovial cells. Cell Immunol 264(1):1–3
CAS PubMed Article Google Scholar
Choi D, Kim C-L, Kim JE, Mo J-S, Jeong H-S (2020) Hesperetin inhibit EMT in TGF-β treated podocyte by regulation of mTOR pathway. Biochem Biophys Res Commun 528(1):154–159
CAS PubMed Article Google Scholar
Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A (2009) Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30(7):1073–1081
CAS PubMed Article Google Scholar
Ding Z, Sun G, Zhu Z (2018) Hesperidin attenuates influenza A virus (H1N1) induced lung injury in rats through its anti-inflammatory effect. SAGE, London, England
Dong W, Wei X, Zhang F, Hao J, Huang F, Zhang C, Liang W (2014) A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways. Sci Rep 4(1):1–12
Garg A, Garg S, Zaneveld L, Singla A (2001) Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res 15(8):655–669
CAS PubMed Article Google Scholar
Gour A, Manhas D, Bag S, Gorain B, Nandi U (2021) Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2. Phytother Res 35(8):4258–4283
CAS PubMed PubMed Central Article Google Scholar
Hermawan A, Ikawati M, Khumaira A, Putri H, Jenie RI, Angraini SM, Muflikhasari HA (2021) Bioinformatics and in vitro studies reveal the importance of p53, PPARG and notch signaling pathway in inhibition of breast cancer stem cells by Hesperetin. Adv Pharm Bull 11(2):351
Jo SH, Kim ME, Cho JH, Lee Y, Lee J, Park Y-D, Lee JS (2019) Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways. Arch Pharmacal Res 42(8):695–703
Jose RJ, Manuel A (2020) COVID-19 cytokine storm: the interplay between inflammation and coagulation. Lancet Respir Med 8(6):e46–e47
CAS PubMed Article Google Scholar
Khezri MR (2021) PI3K/AKT signaling pathway: a possible target for adjuvant therapy in COVID-19. Hum Cell 34(2):700–701
CAS PubMed PubMed Central Article Google Scholar
Khezri MR, Ghasemnejad-Berenji M, Moloodsouri D (2022a) Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS-CoV-2? J Food Biochem. https://doi.org/10.1111/jfbc.14212
Article PubMed PubMed Central Google Scholar
Khezri MR, Varzandeh R, Ghasemnejad-Berenji M (2022b) The probable role and therapeutic potential of the PI3K/AKT signaling pathway in SARS-CoV-2 induced coagulopathy. Cell Mol Biol Lett 27(1):1–10
Li X, Xie X, Zhang L, Meng Y, Li N, Wang M, Zhang L (2019) Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway. Life Sci 219:311–321
CAS PubMed Article Google Scholar
Lin C-W, Tsai F-J, Tsai C-H, Lai C-C, Wan L, Ho T-Y, Chao P-DL (2005) Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Res 68(1):36–42
CAS PubMed PubMed Central Article Google Scholar
Lorzadeh E, Ramezani-Jolfaie N, Mohammadi M, Khoshbakht Y, Salehi-Abargouei A (2019) The effect of hesperidin supplementation on inflammatory markers in human adults: a systematic review and meta-analysis of randomized controlled clinical trials. Chem Biol Interact 307:8–15
CAS PubMed Article Google Scholar
Lu Q, Lai Y, Zhang H, Ren K, Liu W, An Y, Fan H (2022) Hesperetin inhibits TGF-β1-induced migration and invasion of triple negative breast cancer MDA-MB-231 cells via suppressing Fyn/Paxillin/RhoA pathway. Integr Cancer Ther 21:15347354221086900
PubMed PubMed Central Article Google Scholar
Mashayekhi-Sardoo H, Hosseinjani H (2022) A new application of mTOR inhibitor drugs as potential therapeutic agents for COVID-19. J Basic Clin Physiol Pharmacol 33(1):17–25
Meneguzzo F, Ciriminna R, Zabini F, Pagliaro M (2020) Review of evidence available on hesperidin-rich products as potential tools against COVID-19 and hydrodynamic cavitation-based extraction as a method of increasing their production. Processes 8(5):549
Ngwa W, Kumar R, Thompson D, Lyerly W, Moore R, Reid T-E, Toyang N (2020) Potential of flavonoid-inspired phytomedicines against COVID-19. Molecules 25(11):2707
CAS PubMed Central Article Google Scholar
Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M (2015) Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother Res 29(3):323–331
CAS PubMed Article Google Scholar
Parisi GF, Carota G, CastruccioCastracani C, Spampinato M, Manti S, Papale M, Leonardi S (2021) Nutraceuticals in the prevention of viral infections, including COVID-19, among the pediatric population: a review of the literature. Int J Mol Sci 22(5):2465
CAS PubMed PubMed Central Article Google Scholar
Ramaiah MJ (2020) mTOR inhibition and p53 activation, microRNAs: the possible therapy against pandemic COVID-19. Gene Reports 20:100765
CAS PubMed PubMed Central Article Google Scholar
Ren H, Hao J, Liu T, Zhang D, Lv H, Song E, Zhu C (2016) Hesperetin suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 cells via the inhibition of NF-κB and activation of Nrf2/HO-1 pathways. Inflammation 39(3):964–973
Saha RK, Takahashi T, Suzuki T (2009) Glucosyl hesperidin prevents influenza a virus replication in vitro by inhibition of viral sialidase. Biol Pharm Bull 32(7):1188–1192
CAS PubMed Article Google Scholar
Serebrovska ZO, Chong EY, Serebrovska TV, Tumanovska LV, Xi L (2020) Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets. Acta Pharmacol Sin 41(12):1539–1546
CAS PubMed Article Google Scholar
Shirzad M, Heidarian E, Beshkar P, Gholami-Arjenaki M (2017) Biological effects of hesperetin on interleukin-6/phosphorylated signal transducer and activator of transcription 3 pathway signaling in prostate cancer PC3 cells. Pharmacogn Res 9(2):188
Smith A, Teknos TN, Pan Q (2013) Epithelial to mesenchymal transition in head and neck squamous cell carcinoma. Oral Oncol 49(4):287–292
Sohel M, Sultana H, Sultana T, Al Amin M, Aktar S, Ali MC, Amin MN (2022) Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review. Heliyon 8(1):e08815
PubMed PubMed Central Article CAS Google Scholar
Stanisic D, Costa A, Fávaro W, Tasic L, Seabra A (2018) Anticancer activities of hesperidin and hesperetin in vivo and their potentiality against Bladder cancer. J Nanomed Nanptechnol. https://doi.org/10.4172/2157-7439.1000515
Sun J, Li W, Liao H, Li L, Ni H, Chen F, Li Q (2022) Adding sorbitol improves the thermostability of α-l-rhamnosidase from Aspergillus niger and increases the conversion of hesperidin. J Food Biochem 46(2):e14055
Utomo RY, Putri DDP, Salsabila IA, Meiyanto E (2020) The chemopreventive potential of diosmin and hesperidin for COVID-19 and its comorbid diseases. Indones J Cancer Chemoprevention 11(3):154–167
Wang H, Chen G, Guo X, Abbasi AM, Liu RH (2016) Influence of the stage of ripeness on the phytochemical profiles, antioxidant and antiproliferative activities in different parts of Citrus reticulata Blanco cv Chachiensis. LWT-Food Sci Technol 69:67–75
Wu D, Li J, Hu X, Ma J, Dong W (2018) Hesperetin
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