Microbiota mitochondria disorders as hubs for early age-related macular degeneration

Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2:e106–16. https://doi.org/10.1016/S2214-109X(13)70145-1.

Article  PubMed  Google Scholar 

Li JQ, Welchowski T, Schmid M, Mauschitz MM, Holz FG, Finger RP. Prevalence and incidence of age-related macular degeneration in Europe: a systematic review and meta-analysis. Br J Ophthalmol. 2020;104:1077–84. https://doi.org/10.1136/bjophthalmol-2019-314422.

Article  PubMed  Google Scholar 

Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol. 1995;39:367–74. https://doi.org/10.1016/s0039-6257(05)80092-x.

CAS  Article  PubMed  Google Scholar 

Keenan TDL, Cukras CA, Chew EY. Age-related macular degeneration: epidemiology and clinical aspectsrelated macular degeneration: epidemiology and clinical aspects. Adv Exp Med Biol. 2021;1256:1–31. https://doi.org/10.1007/978-3-030-66014-7_1.

CAS  Article  PubMed  Google Scholar 

Spaide RF, Jaffe GJ, Sarraf D, Freund KB, Sadda SR, Staurenghi G, et al. Consensus nomenclature for reporting neovascular age-related macular degeneration data: consensus on neovascular age-related macular degeneration nomenclature study group. Ophthalmology. 2020;127:616–36. https://doi.org/10.1016/j.ophtha.2019.11.004.

Article  PubMed  Google Scholar 

Heesterbeek TJ, Lorés-Motta L, Hoyng CB, Lechanteur YTE, den Hollander AI. Risk factors for progression of age-related macular degeneration. Ophthalmic Physiol Opt. 2020;40:140–70. https://doi.org/10.1111/opo.12675.

Article  PubMed  PubMed Central  Google Scholar 

Nguyen T, Urrutia-Cabrera D, Liou RH, Luu CD, Guymer R, Wong RC. New technologies to study functional genomics of age-related macular degeneration. Front Cell Dev Biol. 2021;8:604220. https://doi.org/10.3389/fcell.2020.604220.

Article  PubMed  PubMed Central  Google Scholar 

Botto C, Rucli M, Tekinsoy MD, Pulman J, Sahel JA, Dalkara D. Early and late stage gene therapy interventions for inherited retinal degenerations. Prog Retin Eye Res. 2022;2022:100975. https://doi.org/10.1016/j.preteyeres.2021.100975.

CAS  Article  Google Scholar 

Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005;308:419–21. https://doi.org/10.1126/science.11103590.

CAS  Article  PubMed  Google Scholar 

Deng Y, Qiao L, Du M, Qu C, Wan L, Li J, Huang L. Age-related macular degeneration: epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy. Genes Dis. 2021;9:62–79. https://doi.org/10.1016/j.gendis.2021.02.009.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Schmitz-Valckenberg S, Fleckenstein M, Zouache MA, Pfau M, Pappas C, Hageman JL, et al. Progression of age-related macular degeneration among individuals homozygous for risk alleles on chromosome 1 (CFH-CFHR5) or chromosome 10 (ARMS2/HTRA1) or both. JAMA Ophthalmol. 2022;140:e216072. https://doi.org/10.1001/jamaophthalmol.2021.6072.

Article  Google Scholar 

Kaarniranta K, Pawlowska E, Szczepanska J, Jablkowska A, Blasiak J. Role of mitochondrial DNA damage in ROS-mediated pathogenesis of age-related macular degeneration (AMD). Int J Mol Sci. 2019;20:2374. https://doi.org/10.3390/ijms20102374.

CAS  Article  PubMed Central  Google Scholar 

Ferrington DA, Kenney MC, Atilano SR, Hurley JB, Brown EE, Ash JD. Mitochondria: the retina’s Achilles’ heel in AMD. Adv Exp Med Biol. 2021;1256:237–64. https://doi.org/10.1007/978-3-030-66014-7_10.

CAS  Article  PubMed  Google Scholar 

Klaver CC, Kliffen M, van Duijn CM, Hofman A, Cruts M, Grobbee DE, et al. Genetic association of apolipoprotein E with age-related macular degeneration. Am J Hum Genet. 1998;63:200–6. https://doi.org/10.1086/301901.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Xiying M, Wenbo W, Wangyi F, Qinghuai L. Association of apolipoprotein E polymorphisms with age-related macular degeneration subtypes: an updated systematic review and meta-analysis. Arch Med Res. 2017;48:370–7. https://doi.org/10.1016/j.arcmed.2017.08.002.

CAS  Article  PubMed  Google Scholar 

Ulańczyk Z, Grabowicz A, Cecerska-Heryć E, Śleboda-Taront D, Krytkowska E, Mozolewska-Piotrowska K, et al. Dietary and lifestyle factors modulate the activity of the endogenous antioxidant system in patients with age-related macular degeneration: correlations with disease severity. Antioxidants (Basel). 2020;9:954. https://doi.org/10.3390/antiox9100954.

CAS  Article  Google Scholar 

Merle BMJ, Colijn JM, Cougnard-Grégoire A, de Koning-Backus APM, Delyfer MN, Kiefte-de Jong JC, et al. Mediterranean diet and incidence of advanced age-related macular degeneration: the EYE-RISK Consortium. Ophthalmology. 2019;126:381–90. https://doi.org/10.1016/j.ophtha.2018.08.006.

Article  PubMed  Google Scholar 

Mares JA, Voland RP, Sondel SA, Millen AE, Larowe T, Moeller SM, et al. Healthy lifestyles related to subsequent prevalence of age-related macular degeneration. Arch Ophthalmol. 2011;129:470–80. https://doi.org/10.1001/archophthalmol.2010.314.

Article  PubMed  Google Scholar 

McGuinness MB, Le J, Mitchell P, Gopinath B, Cerin E, Saksens NTM, et al. Physical activity and age-related macular degeneration: a systematic literature review and meta-analysis. Am J Ophthalmol. 2017;180:29–38. https://doi.org/10.1016/j.ajo.2017.05.016.

Article  PubMed  Google Scholar 

Colijn JM, Meester-Smoor M, Verzijden T, de Breuk A, Silva R, Merle BMJ, et al. Genetic risk, lifestyle, and age-related macular degeneration in Europe: the EYE-RISK Consortium. Ophthalmology. 2021;128:1039–49. https://doi.org/10.1016/j.ophtha.2020.11.024.

Article  PubMed  Google Scholar 

Mettu PS, Wielgus AR, Ong SS, Cousins SW. Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration. Mol Asp Med. 2012;33:376–98. https://doi.org/10.1016/j.mam.2012.04.006.

CAS  Article  Google Scholar 

Brown EE, DeWeerd AJ, Ildefonso CJ, Lewin AS, Ash JD. Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors. Redox Biol. 2019;24:101201. https://doi.org/10.1016/j.redox.2019.101201.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Kauppinen A, Paterno JJ, Blasiak J, Salminen A, Kaarniranta K. Inflammation and its role in age-related macular degeneration. Cell Mol Life Sci. 2016;73:1765–86. https://doi.org/10.1007/s00018-016-2147-8.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Curcio CA. Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies. Invest Ophthalmol Vis Sci. 2018;59:AMD160–81. https://doi.org/10.1167/iovs.18-24882.

Article  PubMed  PubMed Central  Google Scholar 

Ruan Y, Jiang S, Gericke A. Age-related macular degeneration: role of oxidative stress and blood vessels. Int J Mol Sci. 2021;22:1296. https://doi.org/10.3390/ijms22031296.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Romero-Vazquez S, Llorens V, Soler-Boronat A, Figueras-Roca M, Adan A, Molins B. Interlink between inflammation and oxidative stress in age-related macular degeneration: role of complement factor H. Biomedicines. 2021;9:763. https://doi.org/10.3390/biomedicines9070763.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Reiner A, Fitzgerald MEC, Del Mar N, Li C. Neural control of choroidal blood flow. Prog Retin Eye Res. 2018;64:96–130. https://doi.org/10.1016/j.preteyeres.2017.12.001.

Article  PubMed  Google Scholar 

Li C, Fitzgerald MEC, Del Mar N, Wang H, Haughey C, Honig MG, et al. Role of the superior salivatory nucleus in parasympathetic control of choroidal blood flow and in maintenance of retinal health. Exp Eye Res. 2021;206:108541. https://doi.org/10.1016/j.exer.2021.108541.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Ghosh TS, Shanahan F, O’Toole PW. The gut microbiome as a modulator of healthy ageing. Nat Rev Gastroenterol Hepatol. 2022. https://doi.org/10.1038/s41575-022-00605-x.

Leblhuber F, Ehrlich D, Steiner K, Geisler S, Fuchs D, Lanser L, et al. The immunopathogenesis of Alzheimer’s disease is related to the composition of gut microbiota. Nutrients. 2021;13:361. https://doi.org/10.3390/nu13020361.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Zheng SY, Li HX, Xu RC, Miao WT, Dai MY, Ding ST, et al. Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease. Ageing Res Rev. 2021;69:101347. https://doi.org/10.1016/j.arr.2021.101347.

CAS  Article  PubMed  Google Scholar 

Rinninella E, Mele MC, Merendino N, Cintoni M, Anselmi G, Caporossi A, et al. The role of diet, micronutrients and the gut microbiota in age-related macular degeneration: new perspectives from the gut-retina axis. Nutrients. 2018;10:1677. https://doi.org/10.3390/nu10111677.

CAS  Article  PubMed Central  Google Scholar 

Scuderi G, Troiani E, Minnella AM. Gut microbiome in retina health: the crucial role of the gut-retina axis. Front Microbiol. 2022;12:726792. https://doi.org/10.3389/fmicb.2021.726792.

Article  PubMed  PubMed Central  Google Scholar 

Fleckenstein M, Keenan TDL, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, et al. Age-related macular degeneration. Nat Rev Dis Primers. 2021;7:31. https://doi.org/10.1038/s41572-021-00265-2.

Article  PubMed  Google Scholar 

Fu Z, Kern TS, Hellström A, Smith LEH. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2021;62:100035. https://doi.org/10.1194/jlr.TR120000618.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Ho EXP, Cheung CMG, Sim S, Chu CW, Wilm A, Lin CB, et al. Human pharyngeal microbiota in age-related macular degeneration. PLoS One. 2018;13:e0201768. https://doi.org/10.1371/journal.pone.0201768.

CAS  Article  PubMed  PubMed Central 

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