Anti-inflammatory Effect of a Limonin Derivative In Vivo and Its Mechanisms in RAW264.7 Cells

Komatsu, K., J.Y. Lee, M. Miyata, et al. 2013. Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD. Nature Communications 4: 1684.

Article  CAS  Google Scholar 

He, G.Y., M. Xie, Y. Gao, and J.G. Huang. 2015. Sodium ferulate attenuates oxidative stress induced inflammation via suppressing NALP3 and NF-kappaB signal pathway. Sichuan da xue xue bao Yi xue ban = Journal of Sichuan University Medical Science Edition 46 (3): 367–371.

Gao, Q., X. Liang, A.S. Shaikh, J. Zang, W. Xu, and Y. Zhang. 2018. JAK/STAT signal transduction: Promising attractive targets for immune, inflammatory and hematopoietic diseases. Current Drug Targets 19 (5): 487–500.

Article  CAS  Google Scholar 

Yang, Q., Y. Xu, G. Feng, et al. 2014. p38 MAPK signal pathway involved in anti-inflammatory effect of Chaihu-Shugan-San and Shen-ling-bai-zhu-San on hepatocyte in non-alcoholic steatohepatitis rats. African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM 11 (1): 213–221.

PubMed  Google Scholar 

Wang, L., Y. Xu, Q. Yu, et al. 2014. H-RN, a novel antiangiogenic peptide derived from hepatocyte growth factor inhibits inflammation in vitro and in vivo through PI3K/AKT/IKK/NF-kappaB signal pathway. Biochemical Pharmacology 89 (2): 255–265.

Article  CAS  Google Scholar 

Kunihiro, K., T.N. Huu, S. Yukihiro, S. Shigeyuki, M. Takayuki, and T. Takuji. 2012. Dietary Crocin inhibits colitis and colitis-associated colorectal carcinogenesis in male ICR mice. Evidenced-Based Complementary and Alternative Medicine 2012 (4).

Kunnumakkara, A.B., B.L. Sailo, K. Banik, et al. 2018. Chronic diseases, inflammation, and spices: How are they linked? Journal of Translational Medicine 16 (1): 14.

Article  CAS  Google Scholar 

Ma, Z.G., H.Q. Xia, S.L. Cui. et al. 2017. Attenuation of renal ischemic reperfusion injury by salvianolic acid B via suppressing oxidative stress and inflammation through PI3K/Akt signaling pathway. Brazilian Journal of Medical & Biological Research 50 (6).

Cai, J.Y., D.Z. Chen, S.H. Luo, et al. 2014. Limonoids from Aphanamixis polystachya and their antifeedant activity. Journal of Natural Products 77 (3): 472–482.

Article  CAS  Google Scholar 

Choodej, S., D. Sommit, and K. Pudhom. 2013. Rearranged limonoids and chromones from Harrisonia perforata and their anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters 23 (13): 3896–3900.

Article  CAS  Google Scholar 

Joray, M.B., F. Villafanez, M.L. Gonzalez, et al. 2017. P53 tumor suppressor is required for efficient execution of the death program following treatment with a cytotoxic limonoid obtained from Melia azedarach. Food and Chemical Toxicology: An international journal published for the British Industrial Biological Research Association 109 (Pt 2): 888–897.

Article  CAS  Google Scholar 

Zhu, G.Y., L.P. Bai, L. Liu, and Z.H. Jiang. 2014. Limonoids from the fruits of Melia toosendan and their NF-κB modulating activities. Phytochemistry 107: 175.

Article  CAS  Google Scholar 

Bao, Y., H. Li, Q.Y. Li, et al. 2018. Therapeutic effects of Smilax glabra and Bolbostemma paniculatum on rheumatoid arthritis using a rat paw edema model. Biomedicine & Pharmacotherapy 108: 309–315.

Article  CAS  Google Scholar 

Qi, S., Y. Xin, Y. Guo, et al. 2012. Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-kappaB signaling pathways. International Immunopharmacology 12 (1): 278–287.

Article  CAS  Google Scholar 

Chen, X., X. Li, X. Zhai, et al. 2018. Shikimic acid inhibits osteoclastogenesis in vivo and in vitro by blocking RANK/TRAF6 association and suppressing NF-kappaB and MAPK signaling pathways. Cellular Physiology and Biochemistry: International journal of experimental cellular physiology, biochemistry, and pharmacology 51 (6): 2858–2871.

Article  CAS  Google Scholar 

Chen, H., Y. Wu, Z. Chen, et al. 2017. Performance evaluation of a novel sample in-answer out (SIAO) system based on magnetic nanoparticles. Journal of Biomedical Nanotechnology 13 (12): 1619–1630.

Article  CAS  Google Scholar 

Asante, D.B., I.T. Henneh, D.O. Acheampong, et al. 2019. Anti-inflammatory, anti-nociceptive and antipyretic activity of young and old leaves of Vernonia amygdalina. Biomedicine & Pharmacotherapy 111: 1187–1203.

Article  CAS  Google Scholar 

Wang, J.W., S.S. Chen, Y.M. Zhang, et al. 2019. Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice. Environmental Toxicology and Pharmacology 68: 13–18.

Article  CAS  Google Scholar 

Subash, A., G. Veeraraghavan, V.K. Sali, M. Bhardwaj, and H.R. Vasanthi. 2016. Attenuation of inflammation by marine algae Turbinaria ornata in cotton pellet induced granuloma mediated by fucoidan like sulphated polysaccharide. Carbohydrate Polymers 151: 1261–1268.

Article  CAS  Google Scholar 

Shin, J.S., Y. Hong, H.H. Lee, et al. 2015. Fulgidic acid isolated from the rhizomes of Cyperus rotundus suppresses LPS-induced iNOS, COX-2, TNF-alpha, and IL-6 expression by AP-1 inactivation in RAW264.7 macrophages. Biological & Pharmaceutical Bulletin 38 (7): 1081–1086.

Krishnan, S.M., C.G. Sobey, E. Latz, A. Mansell, and G.R. Drummond. 2014. IL-1β and IL-18: Inflammatory markers or mediators of hypertension? British Journal of Pharmacology 171 (24): 5589–5602.

Article  CAS  Google Scholar 

DiDonato, J.A., F. Mercurio, and M. Karin. 2012. NF-kappaB and the link between inflammation and cancer. Immunological Reviews 246 (1): 379–400.

Article  CAS  Google Scholar 

Wang, Z., H. Wesche, T. Stevens, N. Walker, and W.C. Yeh. 2009. IRAK-4 inhibitors for inflammation. Current Topics in Medicinal Chemistry 9 (8): 724–737.

Article  CAS  Google Scholar 

Zhang, J., T. Macartney, M. Peggie, and P. Cohen. 2017. Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. The Biochemical Journal 474 (13): 2235–2248.

Article  CAS  Google Scholar 

Huang, X.L., J. Xu, X.H. Zhang, et al. 2011. PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis. Inflammation Research 60 (8): 727–734.

Article  CAS  Google Scholar 

Sun, Y., Y. Zhao, X. Wang, et al. 2016. Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway. Oncotarget 7 (23): 34300–34315.

Article  Google Scholar 

Wang, Y., Y. Kuramitsu, B. Baron, et al. 2017. PI3K inhibitor LY294002, as opposed to wortmannin, enhances AKT phosphorylation in gemcitabine-resistant pancreatic cancer cells. International Journal of Oncology 50 (2): 606–612.

Article  CAS  Google Scholar 

Jahan, S., D. Kumar, S. Singh, et al. 2018. Resveratrol prevents the cellular damages induced by monocrotophos via PI3K signaling pathway in human cord blood mesenchymal stem cells. Molecular Neurobiology 55 (11): 8278–8292.

Article  CAS  Google Scholar 

Zeinali, M., S.A. Rezaee, and H. Hosseinzadeh. 2017. An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances. Biomedicine & Pharmacotherapy = Biomedecine & pharmacotherapie 92: 998.

Decourt, B., D.K. Lahiri, and M.N. Sabbagh. 2017. Targeting tumor necrosis factor alpha for Alzheimer’s disease. Current Alzheimer Research 14 (4): 412–425.

Article  CAS  Google Scholar 

Liu, D., X. Wang, and Z. Chen. 2016. Tumor necrosis factor-alpha, a regulator and therapeutic agent on breast cancer. Current Pharmaceutical Biotechnology 17 (6): 486–494.

Article  CAS  Google Scholar 

Postal, M., and S. Appenzeller. 2011. The role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus. Cytokine 56 (3): 537–543.

Article  CAS  Google Scholar 

Slevin, S.M., and L.J. Egan. 2015. New insights into the mechanisms of action of anti-tumor necrosis factor-alpha monoclonal antibodies in inflammatory bowel disease. Inflammatory Bowel Diseases 21 (12): 2909–2920.

Article  Google Scholar 

Kawahara, K., H. Hohjoh, T. Inazumi, S. Tsuchiya, and Y. Sugimoto. 2015. Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors. Biochimica Et Biophysica Acta 1851 (4): 414.

Article  CAS  Google Scholar 

Yadav, S.K., B. Adhikary, S.K. Bandyopadhyay, and S. Chattopadhyay. 2013. Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy. Biochimica et Biophysica Acta 1830 (6): 3776–3786.

Article  CAS  Google Scholar 

Clark, K., M. Peggie, L. Plater, et al. 2011. Novel cross-talk within the IKK family controls innate immunity. Biochemical Journal 434 (1): 93–104.

Article  CAS  Google Scholar 

Hinz, M., and C. Scheidereit. 2014. The IκB kinase complex in NF-κB regulation and beyond. EMBO Reports 15 (1): 46–61.

Article  CAS  Google Scholar 

McKenna, S., M. Gossling, A. Bugarini, et al. 2015. Endotoxemia induces IκBβ/NF-κB-dependent endothelin-1 expression in hepatic macrophages. Journal of Immunology (Baltimore, Md: 1950) 195 (8): 3866–3879.

Rao, P., M.S. Hayden, M. Long, et al. 2010. IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature 466 (7310): 1115–1119.

Article  CAS  Google Scholar 

Madianos, P.N., Y.A. Bobetsis, and D.F. Kinane. 2005. Generation of inflammatory stimuli: How bacteria set up inflammatory responses in the gingiva. Journal of Clinical Periodontology 32 Suppl 6 (s6): 57.

Seki, E., and B. Schnabl. 2012. Role of innate immunity and the microbiota in liver fibrosis: Crosstalk between the liver and gut. The Journal of Physiology 590 (3): 447–458.

Article  CAS  Google Scholar 

Xie, S., M. Chen, B. Yan, X. He, X. Chen, and D. Li. 2014. Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells. 9 (4): e94496.

Tas, S.W., P.H. Remans, K.A. Reedquist, and P.P. Tak. 2005. Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: Towards innovative antirheumatic therapy. Current Pharmaceutical Design 11 (5): 581–611.

留言 (0)

沒有登入
gif