Effectiveness and Safety of Acitretin for the Treatment of Hidradenitis Suppurativa, Predictors of Clinical Response: A Cohort Study

Sánchez-Díaz M.Díaz-Calvillo P.a· Rodríguez-Pozo J.Á.a· Arias-Santiago S.a,b· Molina-Leyva A.a,b,c

Author affiliations

aDermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, Granada, Spain
bDermatology Department, School of Medicine, University of Granada, Granada, Spain
cHidradenitis Suppurativa Clinic, Hospital Universitario Virgen de las Nieves, Granada, Spain

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Article / Publication Details

First-Page Preview

Abstract of Research Article

Received: January 13, 2022
Accepted: July 01, 2022
Published online: August 23, 2022

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle which presents with painful nodules, abscesses, and fistulae in apocrine gland-bearing areas of the skin. Approved treatments include antibiotics and biologic drugs such as adalimumab. Despite these treatments, HS management is challenging. Acitretin is an oral retinoid used for its management as 3rd or 4th line therapy. There is little evidence regarding the effectiveness and safety of acitretin treatment for HS, and no reports have previously explored the potential clinical predictors associated with the response to the treatment. Methods: Retrospective cohort study to assess the effectiveness and safety of acitretin treatment in HS patients who failed to respond to topical therapies. Results: Sixty-two patients with moderate to severe HS were included. A significant decrease in the International HS Severity Scoring System (IHS4) score was found over time. Higher basal IHS4 score, family history of HS, follicular phenotype, and history of follicular plugging conditions were potential predictors of response. Most patients did not suffer any adverse events, and no severe side effects were observed. The main cause of discontinuation was lack of efficacy. Conclusion: Acitretin can be considered as a therapeutic option for patients with HS. The presence of follicular phenotype or a history of components of follicular occlusion syndrome is associated with better outcomes.

© 2022 S. Karger AG, Basel

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First-Page Preview

Abstract of Research Article

Received: January 13, 2022
Accepted: July 01, 2022
Published online: August 23, 2022

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

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