Coronavirus disease 2019 (COVID-19) and vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been associated with autoimmune phenomena. However, the interplay between SARS-CoV-2 infection or vaccination against it and Berger glomerulonephritis or Henoch-Schönlein vasculitis, two diseases mediated by immunoglobulin A, has never been comprehensively investigated. Therefore, we carried out a systematic review of the literature on this topic. Following databases were used: Google Scholar, Excerpta Medica and the United States National Library of Medicine. Eighty-seven patients with immunoglobulin A-mediated diseases associated with SARS-CoV-2 infection or vaccination against it were sorted out (53% males, 47% females; 34 (Morisawa and Honda, 2022; Negrea and Rovin, 2021; Niel and Florescu, 2022; Okada et al., 2022; Park et al., 2021; Perrin et al., 2021; Plasse et al., 2021; Rahim et al., 2021; Srinivasan et al., 2022; Tan et al., 2021; Udagawa and Motoyoshi, 2022; Watanabe et al., 2022; Yokote et al., 2022; Apaydın et al., 2021; Huang et al., 2020; Pérez et al., 2021; Badier et al., 2021; Ball-Burack and Kosowsky, 2021; Bostan et al., 2021; Chandwar et al., 2022; Fritzen et al., 2022; Grossman et al., 2021; Hines et al., 2021; Iwata et al., 2021; Kondo and Yamanaka, 2021; Maye et al., 2021; Mohamed et al., 2021; Naitlho et al., 2021; Nakatani et al., 2022; Obeid et al., 2021; Oniszczuk et al., 2021; Park et al., 2021; Sirufo et al., 2021; Al Haji et al., 2021; Al Ghoozi and AlKhayyat, 2021) [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]17-51 years of age, median and interquartile range): 47 cases of Berger glomerulonephritis and 40 of Henoch-Schönlein vasculitis. Approximately 50% (N = 24) of Berger glomerulonephritis and 10% (N = 4) of Henoch-Schönlein vasculitis patients presented with a pre-existing history of immunoglobulin A-mediated disease. Almost all cases of Berger glomerulonephritis were vaccine-associated (N = 44; 94%), while most cases of Henoch-Schönlein vasculitis were infection-associated (N = 23; 57%). Among vaccine-associated immunoglobulin A diseases, about 90% were associated to mRNA-based vaccines. Our analysis supports the hypothesis that SARS-CoV-2 infection coronavirus disease 2019 and vaccination against it may trigger or exacerbate an immunoglobulin A-mediated diseases.