Clinical Practice: Research Article

Misaki T.a,b· Naka S.c· Nagasawa Y.d· Matsuoka D.c· Ito S.e· Nomura R.f,g· Matsumoto-Nakano M.c· Nakano K.g

Author affiliations

aDivision of Nephrology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan
bDepartment of Nursing, Faculty of Nursing, Seirei Christopher University, Hamamatsu, Japan
cDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
dDivision of Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
eDepartment of Internal Medicine, Japan Self-Defense Iruma Hospital, Iruma, Japan
fDepartment of Pediatric Dentistry, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan
gDivision of Oral Infection and Disease Control, Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan

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Article / Publication Details

Received: February 08, 2022
Accepted: June 03, 2022
Published online: August 23, 2022

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 8

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

Abstract

Background: The simultaneous presence of Streptococcus mutans expressing the Cnm protein encoded by cnm (i.e., cnm-positive S. mutans) and Campylobacter rectus in the oral cavity has been associated with proteinuria in patients with IgA nephropathy (IgAN). Objectives: The present study evaluated the relationship between renal function and oral bacteria in patients with IgAN over 5 years of follow-up. Methods: The presence of C. rectus and cnm-positive S. mutans in saliva samples of 117 patients with IgAN was initially evaluated by polymerase chain reaction. Patients were then divided into four groups according to the results of C. rectus and cnm-positive S. mutans detection: group A: C. rectus (−), cnm-positive S. mutans (−); group B: C. rectus (+), cnm-positive S. mutans (−); group C: C. rectus (−), cnm-positive S. mutans (+); and group D: C. rectus (+), cnm-positive S. mutans (+). Clinical characteristics were prospectively followed for 5 years. Results: Serum creatinine levels were significantly higher in group D than in group A over 5 years of follow-up. Additionally, the proportion of patients with an estimated glomerular filtration rate <45 mL/min increased over time; it was significantly greater in group D than in group A over 5 years of follow-up. Conclusion: These results suggest that the simultaneous presence of C. rectus and cnm-positive S. mutans in the oral cavity is associated with renal dysfunction in IgAN patients.

© 2022 S. Karger AG, Basel

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Received: February 08, 2022
Accepted: June 03, 2022
Published online: August 23, 2022

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 8

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: https://www.karger.com/NEF

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