Macrophage-Derived TGF-β and VEGF Promote the Progression of Trauma-Induced Heterotopic Ossification

Kaplan, F.S., D.L. Glaser, N. Hebela, and E.M. Shore. 2004. Heterotopic ossification. Journal of American Academy of Orthopaedic Surgeons 12 (2): 116–125. https://doi.org/10.5435/00124635-200403000-00007.

Article  Google Scholar 

Ranganathan, K., S. Loder, S. Agarwal, V.W. Wong, J. Forsberg, T.A. Davis, S. Wang, A.W. James, and B. Levi. 2015. Heterotopic ossification: Basic-science principles and clinical correlates. Journal of Bone and Joint Surgery. American Volume 97 (13): 1101–1111. https://doi.org/10.2106/JBJS.N.01056.

Article  PubMed  Google Scholar 

Convente, M.R., H. Wang, R.J. Pignolo, F.S. Kaplan, and E.M. Shore. 2015. The immunological contribution to heterotopic ossification disorders. Current Osteoporosis Reports 13 (2): 116–124. https://doi.org/10.1007/s11914-015-0258-z.

Article  PubMed  PubMed Central  Google Scholar 

Loder, S.J., S. Agarwal, M.T. Chung, D. Cholok, C. Hwang, N. Visser, K. Vasquez, M. Sorkin, J. Habbouche, H.H. Sung, J. Peterson, D. Fireman, K. Ranganathan, C. Breuler, C. Priest, J. Li, X. Bai, S. Li, P.S. Cederna, and B. Levi. 2018. Characterizing the circulating cell populations in traumatic heterotopic ossification. American Journal of Pathology 188 (11): 2464–2473. https://doi.org/10.1016/j.ajpath.2018.07.014.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Li, J., Z. Sun, G. Luo, S. Wang, H. Cui, Z. Yao, H. Xiong, Y. He, Y. Qian, and C. Fan. 2021. Quercetin attenuates trauma-induced heterotopic ossification by tuning immune cell infiltration and related inflammatory insult. Frontiers in Immunology 12: 649285. https://doi.org/10.3389/fimmu.2021.649285.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Sun, Z., J. Li, G. Luo, W. Liu, Y. He, F. Wang, Y. Qian, and C. Fan. 2021. Pharmacological activation of SIRT1 by metformin prevented trauma-induced heterotopic ossification through inhibiting macrophage mediated inflammation. European Journal of Pharmacology 909: 174386. https://doi.org/10.1016/j.ejphar.2021.174386.

CAS  Article  PubMed  Google Scholar 

Kraft, C.T., S. Agarwal, K. Ranganathan, V.W. Wong, S. Loder, J. Li, M.J. Delano, and B. Levi. 2016. Trauma-induced heterotopic bone formation and the role of the immune system: A review. Journal of Trauma and Acute Care Surgery 80 (1): 156–165. https://doi.org/10.1097/TA.0000000000000883.

CAS  Article  PubMed  Google Scholar 

Convente, M.R., S.A. Chakkalakal, E. Yang, R.J. Caron, D. Zhang, T. Kambayashi, F.S. Kaplan, and E.M. Shore. 2018. Depletion of mast cells and macrophages impairs heterotopic ossification in an Acvr 1(R206H) mouse model of fibrodysplasia ossificans progressiva. Journal of Bone and Mineral Research 33 (2): 269–282. https://doi.org/10.1002/jbmr.3304.

CAS  Article  PubMed  Google Scholar 

Torossian, F., B. Guerton, A. Anginot, K.A. Alexander, C. Desterke, S. Soave, H.W. Tseng, N. Arouche, L. Boutin, I. Kulina, M. Salga, B. Jose, A.R. Pettit, D. Clay, N. Rochet, E. Vlachos, G. Genet, C. Debaud, P. Denormandie, F. Genet, N.A. Sims, S. Banzet, J.P. Levesque, J.J. Lataillade, and M.C. Le Bousse-Kerdiles. 2017. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight 2 (21). https://doi.org/10.1172/jci.insight.96034.

Sorkin, M., A.K. Huber, C. Hwang, and Carson WFt, Menon R, Li J, Vasquez K, Pagani C, Patel N, Li S, Visser ND, Niknafs Y, Loder S, Scola M, Nycz D, Gallagher K, McCauley LK, Xu J, James AW, Agarwal S, Kunkel S, Mishina Y, and Levi B. 2020. Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nature Communications 11 (1): 722. https://doi.org/10.1038/s41467-019-14172-4.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Epelman, S., K.J. Lavine, and G.J. Randolph. 2014. Origin and functions of tissue macrophages. Immunity 41 (1): 21–35. https://doi.org/10.1016/j.immuni.2014.06.013.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Murray, P.J. 2017. Macrophage polarization. Annual Review of Physiology 79: 541–566. https://doi.org/10.1146/annurev-physiol-022516-034339.

CAS  Article  PubMed  Google Scholar 

Okabe, Y., and R. Medzhitov. 2016. Tissue biology perspective on macrophages. Nature Immunology 17 (1): 9–17. https://doi.org/10.1038/ni.3320.

CAS  Article  PubMed  Google Scholar 

Mantovani, A., S.K. Biswas, M.R. Galdiero, A. Sica, and M. Locati. 2013. Macrophage plasticity and polarization in tissue repair and remodelling. The Journal of Pathology 229 (2): 176–185. https://doi.org/10.1002/path.4133.

CAS  Article  PubMed  Google Scholar 

Crane, J.L., and X. Cao. 2014. Bone marrow mesenchymal stem cells and TGF-beta signaling in bone remodeling. The Journal of Clinical Investigation 124 (2): 466–472. https://doi.org/10.1172/JCI70050.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Kan, C., L. Chen, Y. Hu, N. Ding, H. Lu, Y. Li, J.A. Kessler, and L. Kan. 2018. Conserved signaling pathways underlying heterotopic ossification. Bone 109: 43–48. https://doi.org/10.1016/j.bone.2017.04.014.

CAS  Article  PubMed  Google Scholar 

Lin, J., Y. Yang, W. Zhou, C. Dai, X. Chen, Y. Xie, S. Han, H. Liu, Y. Hu, C. Tang, V. Bunpetch, D. Zhang, Y. Chen, X. Zou, D. Chen, W. Liu, and H. Ouyang. 2022. Single cell analysis reveals inhibition of angiogenesis attenuates the progression of heterotopic ossification in Mkx(-/-) mice. Bone Research 10 (1): 4. https://doi.org/10.1038/s41413-021-00175-9.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Tu, B., S. Liu, B. Yu, J. Zhu, H. Ruan, T. Tang, and C. Fan. 2016. miR-203 inhibits the traumatic heterotopic ossification by targeting Runx2. Cell Death & Disease 7: e2436. https://doi.org/10.1038/cddis.2016.325.

CAS  Article  Google Scholar 

Tu, B., B. Yu, W. Wang, J. Li, F. Yuan, J. Zhu, and C. Fan. 2021. Inhibition of IL-17 prevents the progression of traumatic heterotopic ossification. Journal of Cellular and Molecular Medicine 25 (16): 7709–7719. https://doi.org/10.1111/jcmm.16617.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Griesmann, H., C. Drexel, N. Milosevic, B. Sipos, J. Rosendahl, T.M. Gress, and P. Michl. 2017. Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer. Gut 66 (7): 1278–1285. https://doi.org/10.1136/gutjnl-2015-310049.

CAS  Article  PubMed  Google Scholar 

Dai, J., and A.B. Rabie. 2007. VEGF: An essential mediator of both angiogenesis and endochondral ossification. Journal of Dental Research 86 (10): 937–950. https://doi.org/10.1177/154405910708601006.

CAS  Article  PubMed  Google Scholar 

Hu, K., and B.R. Olsen. 2016. The roles of vascular endothelial growth factor in bone repair and regeneration. Bone 91: 30–38. https://doi.org/10.1016/j.bone.2016.06.013.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Vannella, K.M., and T.A. Wynn. 2017. Mechanisms of organ injury and repair by macrophages. Annual Review of Physiology 79: 593–617. https://doi.org/10.1146/annurev-physiol-022516-034356.

CAS  Article  PubMed  Google Scholar 

Levesque, J.P., N.A. Sims, A.R. Pettit, K.A. Alexander, H.W. Tseng, F. Torossian, F. Genet, J.J. Lataillade, and M.C. Le Bousse-Kerdiles. 2018. Macrophages driving heterotopic ossification: Convergence of genetically-driven and trauma-driven mechanisms. Journal of Bone and Mineral Research 33 (2): 365–366. https://doi.org/10.1002/jbmr.3346.

Article  PubMed  Google Scholar 

Genet, F., I. Kulina, C. Vaquette, F. Torossian, S. Millard, A.R. Pettit, N.A. Sims, A. Anginot, B. Guerton, I.G. Winkler, V. Barbier, J.J. Lataillade, M.C. Le Bousse-Kerdiles, D.W. Hutmacher, and J.P. Levesque. 2015. Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle. The Journal of Pathology 236 (2): 229–240. https://doi.org/10.1002/path.4519.

CAS  Article  PubMed  Google Scholar 

Tirone, M., A. Giovenzana, A. Vallone, P. Zordan, M. Sormani, P.A. Nicolosi, R. Meneveri, C.R. Gigliotti, A.E. Spinelli, R. Bocciardi, R. Ravazzolo, I. Cifola, and S. Brunelli. 2019. Severe heterotopic ossification in the skeletal muscle and endothelial cells recruitment to chondrogenesis are enhanced by monocyte/macrophage depletion. Frontiers in Immunology 10: 1640. https://doi.org/10.3389/fimmu.2019.01640.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gambari, L., F. Grassi, L. Roseti, B. Grigolo, and G. Desando. 2020. Learning from monocyte-macrophage fusion and multinucleation: potential therapeutic targets for osteoporosis and rheumatoid arthritis. International Journal of Molecular Sciences 21 (17). https://doi.org/10.3390/ijms21176001.

Tintut, Y., J. Patel, M. Territo, T. Saini, F. Parhami, and L.L. Demer. 2002. Monocyte/macrophage regulation of vascular calcification in vitro. Circulation 105 (5): 650–655. https://doi.org/10.1161/hc0502.102969.

CAS  Article  PubMed  Google Scholar 

Mirza, R., and T.J. Koh. 2011. Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice. Cytokine 56 (2): 256–264. https://doi.org/10.1016/j.cyto.2011.06.016.

CAS  Article  PubMed  Google Scholar 

Sinder, B.P., A.R. Pettit, and L.K. McCauley. 2015. Macrophages: Their emerging roles in bone. Journal of Bone and Mineral Research 30 (12): 2140–2149. https://doi.org/10.1002/jbmr.2735.

Article  PubMed  Google Scholar 

van Rooijen, N., and E. van Kesteren-Hendrikx. 2002. Clodronate liposomes: Perspectives in research and therapeutics. Journal of Liposome Research 12 (1–2): 81–94. https://doi.org/10.1081/lpr-120004780.

Article  PubMed  Google Scholar 

Legosz, P., K. Drela, L. Pulik, S. Sarzynska, and P. Maldyk. 2018. Challenges of heterotopic ossification-molecular background and current treatment strategies. Clinical and Experimental Pharmacology and Physiology 45 (12): 1229–1235. https://doi.org/10.1111/1440-1681.13025.

CAS  Article  PubMed  Google Scholar 

Kusumbe, A.P., S.K. Ramasamy, and R.H. Adams. 2014. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 507 (7492): 323–328. https://doi.org/10.1038/nature13145.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Lin, L., Q. Shen, H. Leng, X. Duan, X. Fu, and C. Yu. 2011. Synergistic inhibition of endochondral bone formation by silencing Hif1alpha and Runx2 in trauma-induced heterotopic ossification. Molecular Therapy 19 (8): 1426–1432. https://doi.org/10.1038/mt.2011.101.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Hwang, C., S. Marini, A.K. Huber, D.M. Stepien, M. Sorkin, S. Loder, C.A. Pagani, J. Li, N.D. Visser, K. Vasquez, M.A. Garada, S. Li, J. Xu, C.Y. Hsu, P.B. Yu, A.W. James, Y. Mishina, S. Agarwal, J. Li, and B. Levi. 2019. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Research 7: 36. https://doi.org/10.1038/s41413-019-0075-6.

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