Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking

Gainetdinov, R. R., Premont, R. T., Bohn, L. M., Lefkowitz, R. J. & Caron, M. G. Desensitization of G protein-coupled receptors and neuronal functions. Annu. Rev. Neurosci. 27, 107–144 (2004).

CAS  PubMed  Article  Google Scholar 

Abramow-Newerly, M., Roy, A. A., Nunn, C. & Chidiac, P. RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins. Cell Signal. 18, 579–591 (2006).

CAS  PubMed  Article  Google Scholar 

Hilger, D., Masureel, M. & Kobilka, B. K. Structure and dynamics of GPCR signaling complexes. Nat. Struct. Mol. Biol. 25, 4–12 (2018).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Collett, B. J. Opioid tolerance: the clinical perspective. Br. J. Anaesth. 81, 58–68 (1998).

CAS  PubMed  Article  Google Scholar 

Martyn, J. A. J., Mao, J. & Bittner, E. A. Opioid tolerance in critical illness. N. Engl. J. Med. 380, 365–378 (2019).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Colvin, L. A., Bull, F. & Hales, T. G. Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia. Lancet 393, 1558–1568 (2019).

PubMed  Article  Google Scholar 

Darcq, E. & Kieffer, B. L. Opioid receptors: drivers to addiction? Nat. Rev. Neurosci. 19, 499–514 (2018).

CAS  PubMed  Article  Google Scholar 

Matthes, H. W. et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene. Nature 383, 819–823 (1996).

CAS  PubMed  Article  Google Scholar 

Williams, J. T. et al. Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharm. Rev. 65, 223–254 (2013).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Corder, G. et al. Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. Nat. Med. 23, 164–173 (2017).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shenoy, S. K. & Lefkowitz, R. J. β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol. Sci. 32, 521–533 (2011).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bohn, L. M., Gainetdinov, R. R., Lin, F. T., Lefkowitz, R. J. & Caron, M. G. μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence. Nature 408, 720–723 (2000).

CAS  PubMed  Article  Google Scholar 

Gillis, A. et al. Critical assessment of G protein-biased agonism at the μ-opioid receptor. Trends Pharmacol. Sci. 41, 947–959 (2020).

CAS  PubMed  Article  Google Scholar 

Terzi, D., Cao, Y., Agrimaki, I., Martemyanov, K. A. & Zachariou, V. R7BP modulates opiate analgesia and tolerance but not withdrawal. Neuropsychopharmacology 37, 1005–1012 (2012).

CAS  PubMed  Article  Google Scholar 

Wang, Y. et al. Blockade of PDGFR-β activation eliminates morphine analgesic tolerance. Nat. Med. 18, 385–387 (2012).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Inoue, M. & Ueda, H. Protein kinase C-mediated acute tolerance to peripheral μ-opioid analgesia in the bradykinin-nociception test in mice. J. Pharmacol. Exp. Ther. 293, 662–669 (2000).

CAS  PubMed  Google Scholar 

Zhou, J. et al. Molecular mechanisms of opioid tolerance: from opioid receptors to inflammatory mediators (review). Exp. Ther. Med. 22, 1004 (2021).

Wang, D. et al. Genetic behavioral screen identifies an orphan anti-opioid system. Science https://doi.org/10.1126/science.aau2078 (2019).

Minevich, G., Park, D. S., Blankenberg, D., Poole, R. J. & Hobert, O. CloudMap: a cloud-based pipeline for analysis of mutant genome sequences. Genetics 192, 1249–1269 (2012).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhong, Y., Gu, L. J., Sun, X. G., Yang, S. H. & Zhang, X. H. Comprehensive analysis of patched domain-containing genes reveals a unique evolutionary pattern. Genet. Mol. Res. 13, 7318–7331 (2014).

CAS  PubMed  Article  Google Scholar 

Tora, D. et al. Cellular functions of the autism risk factor PTCHD1 in mice. J. Neurosci. 37, 11993–12005 (2017).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wells, M. F., Wimmer, R. D., Schmitt, L. I., Feng, G. & Halassa, M. M. Thalamic reticular impairment underlies attention deficit in Ptchd1Y/− mice. Nature 532, 58–63 (2016).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Noor, A. et al. Disruption at the PTCHD1 locus on Xp22.11 in autism spectrum disorder and intellectual disability. Sci. Transl. Med. 2, 49ra68 (2010).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Hawrylycz, M. J. et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature 489, 391–399 (2012).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ung, D. C. et al. Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse. Mol. Psychiatry 23, 1356–1367 (2018).

CAS  PubMed  Article  Google Scholar 

Matsui, A., Jarvie, B. C., Robinson, B. G., Hentges, S. T. & Williams, J. T. Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal. Neuron 82, 1346–1356 (2014).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Nestler, E. J. Is there a common molecular pathway for addiction? Nat. Neurosci. 8, 1445–1449 (2005).

CAS  PubMed  Article  Google Scholar 

Khomula, E. V., Araldi, D., Bonet, I. J. M. & Levine, J. D. Opioid-induced hyperalgesic priming in single nociceptors. J. Neurosci. 41, 31–46 (2021).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Claing, A., Laporte, S. A., Caron, M. G. & Lefkowitz, R. J. Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and β-arrestin proteins. Prog. Neurobiol. 66, 61–79 (2002).

CAS  PubMed  Article  Google Scholar 

Li, X., Saha, P., Li, J., Blobel, G. & Pfeffer, S. R. Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2. Proc. Natl Acad. Sci. USA 113, 10079–10084 (2016).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhang, Y. et al. Structural basis for cholesterol transport-like activity of the hedgehog receptor patched. Cell 175, 1352–1364 e14 (2018).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Qiu, Y., Wang, Y., Law, P. Y., Chen, H. Z. & Loh, H. H. Cholesterol regulates μ-opioid receptor-induced β-arrestin 2 translocation to membrane lipid rafts. Mol. Pharmacol. 80, 210–218 (2011).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Barter, P. J., Brandrup-Wognsen, G., Palmer, M. K. & Nicholls, S. J. Effect of statins on HDL-C: a complex process unrelated to changes in LDL-C: analysis of the VOYAGER Database. J. Lipid Res. 51, 1546–1553 (2010).

CAS  PubMed  PubMed Central  Article  Google Scholar 

McTaggart, F. & Jones, P. Effects of statins on high-density lipoproteins: a potential contribution to cardiovascular benefit. Cardiovasc. Drugs Ther. 22, 321–338 (2008).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Niu, Z. et al. Melanocortin 4 receptor antagonists attenuates morphine antinociceptive tolerance, astroglial activation and cytokines expression in the spinal cord of rat. Neurosci. Lett. 529, 112–117 (2012).

CAS  PubMed  Article  Google Scholar 

Lamberts, J. T., Rosenthal, L. D., Jutkiewicz, E. M. & Traynor, J. R. Role of the guanine nucleotide binding protein, Gαo, in the development of morphine tolerance and dependence. Psychopharmacol. (Berl.) 235, 71–82 (2018).

CAS  Article  Google Scholar 

Sanna, M. D., Borgonetti, V. & Galeotti, N. μ Opioid receptor-triggered Notch-1 activation contributes to morphine tolerance: role of neuron–glia communication. Mol. Neurobiol. 57, 331–345 (2020).

CAS  PubMed  Article  Google Scholar 

Toda, N., Kishioka, S., Hatano, Y. & Toda, H. Modulation of opioid actions by nitric oxide signaling. Anesthesiology 110, 166–181 (2009).

CAS  PubMed  Article  Google Scholar 

Vidal, B. et al. An atlas of Caenorhabditis elegans chemoreceptor expression. PLoS Biol. 16, e2004218 (2018).

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