Urinary extracellular vesicle mRNA analysis of sodium chloride cotransporter in hypertensive patients under different conditions

Dominguez JH, Liu Y, Gao H, Dominguez JM 2nd, Xie D, Kelly KJ. Renal Tubular Cell-Derived Extracellular Vesicles Accelerate the Recovery of Established Renal Ischemia Reperfusion Injury. J Am Soc Nephrol. 2017;28:3533–44.

CAS  Article  Google Scholar 

Gildea JJ, Seaton JE, Victor KG, Reyes CM, Bigler Wang D, Pettigrew AC, et al. Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells. Clin Biochem. 2014;47:89–94.

CAS  Article  Google Scholar 

Erdbrugger U, Blijdorp CJ, Bijnsdorp IV, Borras FE, Burger D, Bussolati B, et al. Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. J Extracell Vesicles. 2021;10:e12093.

Article  Google Scholar 

Nawaz M, Camussi G, Valadi H, Nazarenko I, Ekstrom K, Wang X, et al. The emerging role of extracellular vesicles as biomarkers for urogenital cancers. Nat Rev Urol. 2014;11:688–701.

Article  Google Scholar 

Greening DW, Simpson RJ. Understanding extracellular vesicle diversity - current status. Expert Rev Proteom. 2018;15:887–910.

CAS  Article  Google Scholar 

Carvajal CA, Tapia-Castillo A, Perez JA, Fardella CE. Primary Aldosteronism, Aldosterone, and Extracellular Vesicles. Endocrinology. 2022;163:bqab240.

Qi Y, Wang X, Rose KL, MacDonald WH, Zhang B, Schey KL, et al. Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion. J Am Soc Nephrol. 2016;27:646–56.

CAS  Article  Google Scholar 

Wolley MJ, Wu A, Xu S, Gordon RD, Fenton RA, Stowasser M. In Primary Aldosteronism, Mineralocorticoids Influence Exosomal Sodium-Chloride Cotransporter Abundance. J Am Soc Nephrol. 2017;28:56–63.

CAS  Article  Google Scholar 

van der Lubbe N, Jansen PM, Salih M, Fenton RA, van den Meiracker AH, Danser AH, et al. The phosphorylated sodium chloride cotransporter in urinary exosomes is superior to prostasin as a marker for aldosteronism. Hypertension. 2012;60:741–8.

Article  Google Scholar 

Castagna A, Pizzolo F, Chiecchi L, Morandini F, Channavajjhala SK, Guarini P, et al. Circadian exosomal expression of renal thiazide-sensitive NaCl cotransporter (NCC) and prostasin in healthy individuals. Proteom Clin Appl. 2015;9:623–9.

CAS  Article  Google Scholar 

Corbetta S, Raimondo F, Tedeschi S, Syren ML, Rebora P, Savoia A, et al. Urinary exosomes in the diagnosis of Gitelman and Bartter syndromes. Nephrol Dial Transpl. 2015;30:621–30.

CAS  Article  Google Scholar 

O’Shaughnessy KM. Gordon Syndrome: a continuing story. Pediatr Nephrol. 2015;30:1903–8.

Article  Google Scholar 

Miranda KC, Bond DT, McKee M, Skog J, Paunescu TG, Da Silva N, et al. Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease. Kidney Int. 2010;78:191–9.

Article  Google Scholar 

Bazzell BG, Rainey WE, Auchus RJ, Zocco D, Bruttini M, Hummel SL, et al. Human Urinary mRNA as a Biomarker of Cardiovascular Disease A Proof-of-Principle Study of Sodium Loading in Prehypertension. Circ Genom Precis Med. 2018;11:e002213.

Spanu S, van Roeyen CRC, Denecke B, Floege J, Muhlfeld AS. Urinary Exosomes: A Novel Means to Non-Invasively Assess Changes in Renal Gene and Protein Expression. Plos One. 2014;9:e109631.

Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750.

Article  Google Scholar 

Ko B, Mistry AC, Hanson L, Mallick R, Wynne BM, Thai TL, et al. Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway. Am J Physiol Ren Physiol. 2013;305:F645–52.

CAS  Article  Google Scholar 

Feng X, Zhang Y, Shao N, Wang Y, Zhuang Z, Wu P, et al. Aldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway.2015;308: F1119-27.

Olivieri O, Ciacciarelli A, Signorelli D, Pizzolo F, Guarini P, Pavan C, et al. Aldosterone to Renin ratio in a primary care setting: the Bussolengo study. J Clin Endocrinol Metab. 2004;89:4221–6.

CAS  Article  Google Scholar 

Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H, et al. The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101:1889–916.

CAS  Article  Google Scholar 

Mulatero P, Milan A, Fallo F, Regolisti G, Pizzolo F, Fardella C, et al. Comparison of confirmatory tests for the diagnosis of primary aldosteronism. J Clin Endocrinol Metab. 2006;91:2618–23.

CAS  Article  Google Scholar 

Pizzolo F, Salvagno G, Caruso B, Cocco C, Zorzi F, Zaltron C, et al. Fully automated chemiluminescence vs RIA aldosterone assay in primary aldosteronism work-up. J Hum Hypertens. 2017;31:826–30.

CAS  Article  Google Scholar 

Olivieri O, Castagna A, Guarini P, Chiecchi L, Sabaini G, Pizzolo F, et al. Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans. Hypertension. 2005;46:683–8.

CAS  Article  Google Scholar 

Zhou H, Yuen PS, Pisitkun T, Gonzales PA, Yasuda H, Dear JW, et al. Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int. 2006;69:1471–6.

CAS  Article  Google Scholar 

Wardak H, Tutakhel OAZ, Van Der Wijst J. Role of the alternative splice variant of NCC in blood pressure control. Channels (Austin). 2018;12:346–55.

Article  Google Scholar 

Bazzell BG, Rainey WE, Auchus RJ, Zocco D, Bruttini M, Hummel SL, et al. Human Urinary mRNA as a Biomarker of Cardiovascular Disease. Circ Genom Precis Med. 2018;11:e002213.

CAS  Article  Google Scholar 

Gunasekaran PM, Luther JM, Byrd JB. For what factors should we normalize urinary extracellular mRNA biomarkers? Biomol Detect Quantif. 2019;17:100090.

CAS  Article  Google Scholar 

McKiernan J, Donovan MJ, O’Neill V, Bentink S, Noerholm M, Belzer S, et al. A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy. JAMA Oncol. 2016;2:882–9.

Article  Google Scholar 

Gracia T, Wang X, Su Y, Norgett EE, Williams TL, Moreno P, et al. Urinary Exosomes Contain MicroRNAs Capable of Paracrine Modulation of Tubular Transporters in Kidney. Sci Rep. 2017;7:40601.

CAS  Article  Google Scholar 

Hoorn EJ, Gritter M, Cuevas CA, Fenton RA. Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis. Physiol Rev. 2020;100:321–56.

CAS  Article  Google Scholar 

Wu A, Wolley MJ, Wu Q, Gordon RD, Fenton RA, Stowasser M. The Cl(-)/HCO3(-) exchanger pendrin is downregulated during oral co-administration of exogenous mineralocorticoid and KCl in patients with primary aldosteronism. J Hum Hypertens. 2021;35:837–48.

CAS  Article  Google Scholar 

Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci . 1998;95:14552–7.

CAS  Article  Google Scholar 

Poulsen SB, Christensen BM. Long-term aldosterone administration increases renal Na(+)-Cl(-) cotransporter abundance in late distal convoluted tubule. Am J Physiol Ren Physiol. 2017;313:F756–F66.

CAS  Article  Google Scholar 

Czogalla J, Vohra T, Penton D, Kirschmann M, Craigie E, Loffing J. The mineralocorticoid receptor (MR) regulates ENaC but not NCC in mice with random MR deletion. Pflug Arch: Eur J Physiol. 2016;468:849–58.

CAS  Article  Google Scholar 

van der Lubbe N, Lim CH, Meima ME, van Veghel R, Rosenbaek LL, Mutig K, et al. Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway. Pflug Arch. 2012;463:853–63.

CAS  Article  Google Scholar 

Wang XY, Masilamani S, Nielsen J, Kwon TH, Brooks HL, Nielsen S, et al. The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest. 2001;108:215–22.

CAS  Article  Google Scholar 

Esteva-Font C, Wang X, Ars E, Guillen-Gomez E, Sans L, Gonzalez Saavedra I, et al. Are sodium transporters in urinary exosomes reliable markers of tubular sodium reabsorption in hypertensive patients? Nephron Physiol. 2010;114:p25–34.

CAS  Article  Google Scholar 

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