Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646.

CAS  PubMed  Article  Google Scholar 

Wang YA, Li XL, Mo YZ, Fan CM, Tang L, Xiong F, et al. Effects of tumor metabolic microenvironment on regulatory T cells. Mol Cancer. 2018;17(1):168.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Liu F, Qin L, Liao Z, Song J, Yuan C, Liu Y, et al. Microenvironment characterization and multi-omics signatures related to prognosis and immunotherapy response of hepatocellular carcinoma. Exp Hematol Oncol. 2020;9:10.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fu T, Dai LJ, Wu SY, Xiao Y, Ma D, Jiang YZ, et al. Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response. J Hematol Oncol. 2021;14(1):98.

PubMed  PubMed Central  Article  Google Scholar 

Dunn G, Bruce A, Ikeda H, Old L, Schreiber R. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3(11):991–8.

CAS  PubMed  Article  Google Scholar 

Wu W, Liu Y, Zeng S, Han Y, Shen H. Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes. J Hematol Oncol. 2021;14(1):160.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Baitsch L, Baumgaertner P, Devêvre E, Raghav S, Legat A, Barba L, et al. Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients. J Clin Invest. 2011;121(6):2350–60.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wherry E. T cell exhaustion. Nat Immunol. 2011;12(6):492–9.

CAS  PubMed  Article  Google Scholar 

Yi M, Niu M, Zhang J, Li S, Zhu S, Yan Y, et al. Combine and conquer: manganese synergizing anti-TGF-β/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers. J Hematol Oncol. 2021;14(1):146.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Li Y, Zhang Y, Cao G, Zheng X, Sun C, Wei H, et al. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors. J Hematol Oncol. 2021;14(1):100.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Swann J, Smyth M. Immune surveillance of tumors. J Clin Invest. 2007;117(5):1137–46.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Yang Z, Guo J, Weng L, Tang W, Jin S, Ma W. Myeloid-derived suppressor cells-new and exciting players in lung cancer. J Hematol Oncol. 2020;13(1):10.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Qiu Y, Chen T, Hu R, Zhu R, Li C, Ruan Y, et al. Next frontier in tumor immunotherapy: macrophage-mediated immune evasion. Biomark Res. 2021;9(1):72.

PubMed  PubMed Central  Article  Google Scholar 

Hao Z, Li R, Wang Y, Li S, Hong Z, Han Z. Landscape of myeloid-derived suppressor cell in tumor immunotherapy. Biomark Res. 2021;9(1):77.

PubMed  PubMed Central  Article  Google Scholar 

Wang L, He T, Liu J, Tai J, Wang B, Chen Z, et al. Pan-cancer analysis reveals tumor-associated macrophage communication in the tumor microenvironment. Exp Hematol Oncol. 2021;10(1):31.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhu S, Yi M, Wu Y, Dong B, Wu K. Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies. Exp Hematol Oncol. 2021;10(1):60.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Xu T, Yu S, Zhang J, Wu S. Dysregulated tumor-associated macrophages in carcinogenesis, progression and targeted therapy of gynecological and breast cancers. J Hematol Oncol. 2021;14(1):181.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell. 2008;133(5):775–87.

CAS  PubMed  Article  Google Scholar 

Zou L, Barnett B, Safah H, Larussa V, Evdemon-Hogan M, Mottram P, et al. Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals. Cancer Res. 2004;64(22):8451–5.

CAS  PubMed  Article  Google Scholar 

Iellem A, Mariani M, Lang R, Recalde H, Panina-Bordignon P, Sinigaglia F, et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med. 2001;194(6):847–53.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Liu M, Liu W, Qin Y, Xu X, Ji S. Regulation of metabolic reprogramming by tumor suppressor genes in pancreatic cancer. Exp Hematol Oncol. 2020;9(1):23.

Article  Google Scholar 

Leone RD, Powell JD. Metabolism of immune cells in cancer. Nat Rev Cancer. 2020;20(9):516–31.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhang Y, Mao Q, Xia Q, Cheng J, Huang Z, Li Y, et al. Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers. J Hematol Oncol. 2021;14(1):169.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lim SA, Wei J, Nguyen T-LM, Shi H, Su W, Palacios G, et al. Lipid signalling enforces functional specialization of Treg cells in tumours. Nature. 2021;591(7849):306–11.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, et al. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature. 2021;591(7851):645–51.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, et al. CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours. Nature. 2021;591(7851):652–8.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bluestone JA, Anderson M. Tolerance in the age of immunotherapy. N Engl J Med. 2020;383(12):1156–66.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Gershon R, Kondo K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology. 1970;18(5):723–37.

CAS  PubMed  PubMed Central  Google Scholar 

Gershon R, Kondo K. Infectious immunological tolerance. Immunology. 1971;21(6):903–14.

CAS  PubMed  PubMed Central  Google Scholar 

Bullock W, Katz D, Benacerraf B. Induction of T-lymphocyte responses to a small molecular weight antigen. III. T-T cell interactions to determinants linked together: suppression vs. enhancement. J Exp Med. 1975;142(2):275–87.

CAS  PubMed  Article  Google Scholar 

Swierkosz JE, Swanborg RH. Suppressor cell control of unresponsiveness to experimental allergic encephalomyelitis. J Immunol. 1975;115(3):631–3.

CAS  PubMed  Google Scholar 

Liew F. Regulation of delayed-type hypersensitivity. I. T suppressor cells for delayed-type hypersensitivity to sheep erythrocytes in mice. Eur J Immunol. 1977;7(10):714–8.

CAS  PubMed  Article  Google Scholar 

Schatten S, Granstein R, Drebin J, Greene M. Suppressor T cells and the immune response to tumors. Crit Rev Immunol. 1984;4(4):335–79.

CAS  PubMed  Google Scholar 

Berendt M, North R. T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor. J Exp Med. 1980;151(1):69–80.

CAS  PubMed  Article  Google Scholar 

Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med. 1996;184(2):387–96.

CAS  PubMed  Article  Google Scholar 

Ramsdell F, Ziegler S. FOXP3 and scurfy: how it all began. Nat Rev Immunol. 2014;14(5):343–9.

CAS  PubMed  Article  Google Scholar 

Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609):1057–61.

CAS  PubMed  Article 

留言 (0)

沒有登入
gif