Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway

Maris JM. Recent advances in neuroblastoma. N Engl J Med. 2010;362(23):2202–11. https://doi.org/10.1056/NEJMra0804577.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer. 2003;3(3):203–16. https://doi.org/10.1038/nrc1014.

CAS  Article  PubMed  Google Scholar 

Matthay KK, Maris JM, Schleiermacher G, Nakagawara A, Mackall CL, Diller L, Weiss WA. Neuroblastoma. Nat Rev Disease Primers. 2016;2:16078. https://doi.org/10.1038/nrdp.2016.78.

Article  PubMed  Google Scholar 

Maris JM, Hogarty MD, Bagatell R, Cohn SL. Neuroblastoma. Lancet (London, England). 2007;369(9579):2106–20. https://doi.org/10.1016/S0140-6736(07)60983-0.

CAS  Article  Google Scholar 

Baker DL, Schmidt ML, Cohn SL, Maris JM, London WB, Buxton A, Stram D, Castleberry RP, Shimada H, Sandler A, Shamberger RC, Look AT, Reynolds CP, Seeger RC, Matthay KK, Children’s Oncology Group. Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. N Engl J Med. 2010;363(14):1313–23. https://doi.org/10.1056/NEJMoa1001527.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Strother DR, London WB, Schmidt ML, Brodeur GM, Shimada H, Thorner P, Collins MH, Tagge E, Adkins S, Reynolds CP, Murray K, Lavey RS, Matthay KK, Castleberry R, Maris JM, Cohn SL. Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children’s Oncology Group study P9641. J Clinical Oncol. 2012;30(15):1842–8. https://doi.org/10.1200/JCO.2011.37.9990.

CAS  Article  Google Scholar 

Zafar A, Wang W, Liu G, Wang X, Xian W, McKeon F, Foster J, Zhou J, Zhang R. Molecular targeting therapies for neuroblastoma: Progress and challenges. Med Res Rev. 2021;41(2):961–1021. https://doi.org/10.1002/med.21750.

Article  PubMed  Google Scholar 

Whittle SB, Smith V, Doherty E, Zhao S, McCarty S, Zage PE. Overview and recent advances in the treatment of neuroblastoma. Expert Rev Anticancer Ther. 2017;17(4):369–86. https://doi.org/10.1080/14737140.2017.1285230.

CAS  Article  PubMed  Google Scholar 

Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, Luan G, Yagasaki K, Zhang G. Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology. 2009;59(3):191–200. https://doi.org/10.1007/s10616-009-9211-2.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Li LQ, Li XL, Wang L, Du WJ, Guo R, Liang HH, Liu X, Liang DS, Lu YJ, Shan HL, Jiang HC. Matrine inhibits breast cancer growth via miR-21/PTEN/Akt pathway in MCF-7 cells. Cellular Physiol Biochem. 2012;30(3):631–41. https://doi.org/10.1159/000341444.

CAS  Article  Google Scholar 

Zhang J, Li Y, Chen X, Liu T, Chen Y, He W, Zhang Q, Liu S. Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells. Oncol Rep. 2011;26(1):115–24. https://doi.org/10.3892/or.2011.1277.

CAS  Article  PubMed  Google Scholar 

Zhang S, Zhang Y, Zhuang Y, Wang J, Ye J, Zhang S, Wu J, Yu K, Han Y. Matrine induces apoptosis in human acute myeloid leukemia cells via the mitochondrial pathway and Akt inactivation. PLoS ONE. 2012;7(10): e46853. https://doi.org/10.1371/journal.pone.0046853.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chen H, Zhang J, Luo J, Lai F, Wang Z, Tong H, Lu D, Bu H, Zhang R, Lin S. Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-κB-mediated VEGF signaling pathway. Oncol Rep. 2013;30(2):589–95. https://doi.org/10.3892/or.2013.2529.

CAS  Article  PubMed  Google Scholar 

Zhang X, Hou G, Liu A, Xu H, Guan Y, Wu Y, Deng J, Cao X. Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways. Cell Death Dis. 2019;10(10):770. https://doi.org/10.1038/s41419-019-2013-3.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Zhang JQ, Li YM, Liu T, He WT, Chen YT, Chen XH, Li X, Zhou WC, Yi JF, Ren ZJ. Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy. World J Gastroenterol. 2010;16(34):4281–90. https://doi.org/10.3748/wjg.v16.i34.4281.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Li Q, Lai Y, Wang C, Xu G, He Z, Shang X, Sun Y, Zhang F, Liu L, Huang H. Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway. Oncol Rep. 2016;35(1):375–81. https://doi.org/10.3892/or.2015.4341.

CAS  Article  PubMed  Google Scholar 

Chang CH, Bijian K, Wernic D, Su J, da Silva SD, Yu H, Qiu D, Asslan M, Alaoui-Jamali MA. A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to metastasis by inducing cytostatic autophagy. Autophagy. 2019;15(8):1376–90. https://doi.org/10.1080/15548627.2019.1582951.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gewirtz DA. The four faces of autophagy: implications for cancer therapy. Can Res. 2014;74(3):647–51. https://doi.org/10.1158/0008-5472.CAN-13-2966.

CAS  Article  Google Scholar 

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2021;17(1):1–382. https://doi.org/10.1080/15548627.2020.1797280.

Article  PubMed  PubMed Central  Google Scholar 

Wu Y, Wang X, Guo H, Zhang B, Zhang XB, Shi ZJ, Yu L. Synthesis and screening of 3-MA derivatives for autophagy inhibitors. Autophagy. 2013;9(4):595–603. https://doi.org/10.4161/auto.23641.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000;103(2):253–62. https://doi.org/10.1016/s0092-8674(00)00117-3.

CAS  Article  PubMed  Google Scholar 

Sun X, Kaufman PD. Ki-67: more than a proliferation marker. Chromosoma. 2018;127(2):175–86. https://doi.org/10.1007/s00412-018-0659-8.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer. 2005;5(9):726–34. https://doi.org/10.1038/nrc1692.

CAS  Article  PubMed  Google Scholar 

Parzych KR, Klionsky DJ. An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal. 2014;20(3):460–73. https://doi.org/10.1089/ars.2013.5371.

CAS  Article  PubMed  PubMed Central  Google Scholar 

White E, Mehnert JM, Chan CS. Autophagy, metabolism, and cancer. Clinical Cancer Res. 2015;21(22):5037–46. https://doi.org/10.1158/1078-0432.CCR-15-0490.

CAS  Article  Google Scholar 

Amaravadi RK, Kimmelman AC, Debnath J. Targeting autophagy in cancer: recent advances and future directions. Cancer Discov. 2019;9(9):1167–81. https://doi.org/10.1158/2159-8290.CD-19-0292.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Katayama M, Kawaguchi T, Berger MS, Pieper RO. DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ. 2007;14(3):548–58. https://doi.org/10.1038/sj.cdd.4402030.

CAS  Article  PubMed  Google Scholar 

Liu R, Li J, Zhang T, Zou L, Chen Y, Wang K, Lei Y, Yuan K, Li Y, Lan J, Cheng L, Xie N, Xiang R, Nice EC, Huang C, Wei Y. Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking. Autophagy. 2014;10(7):1241–55. https://doi.org/10.4161/auto.28912.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chude CI, Amaravadi RK. Targeting autophagy in cancer: update on clinical trials and novel inhibitors. Int J Mol Sci. 2017;18(6):1279. https://doi.org/10.3390/ijms18061279.

CAS  Article  PubMed Central  Google Scholar 

Qureshi-Baig K, Kuhn D, Viry E, Pozdeev VI, Schmitz M, Rodriguez F, Ullmann P, Koncina E, Nurmik M, Frasquilho S, Nazarov PV, Zuegel N, Boulmont M, Karapetyan Y, Antunes L, Val D, Mittelbronn M, Janji B, Haan S, Letellier E. Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway. Autophagy. 2020;16(8):1436–52. https://doi.org/10.1080/15548627.2019.1687213.

CAS  Article  PubMed  Google Scholar 

Rebecca VW, Nicastri MC, Fennelly C, Chude CI, Barber-Rotenberg JS, Ronghe A, McAfee Q, McLaughlin NP, Zhang G, Goldman AR, Ojha R, Piao S, Noguera-Ortega E, Martorella A, Alicea GM, Lee JJ, Schuchter LM, Xu X, Herlyn M, Marmorstein R, Amaravadi RK. PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer. Cancer Discov. 2019;9(2):220–9. https://doi.org/10.1158/2159-8290.CD-18-0706.

CAS  Article  PubMed  Google Scholar 

Dou Q, Chen HN, Wang K, Yuan K, Lei Y, Li K, Lan J, Chen Y, Huang Z, Xie N, Zhang L, Xiang R, Nice EC, Wei Y, Huang C. Ivermectin induces cytostatic autophagy by blocking the PAK1/Akt axis in breast cancer. Can Res. 2016;76(15):4457–69. https://doi.org/10.1158/0008-5472.CAN-15-2887.

CAS  Article  Google Scholar 

Cao C, Subhawong T, Albert JM, Kim KW, Geng L, Sekhar KR, Gi YJ, Lu B. Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Can Res. 2006;66(20):10040–7. https://doi.org/10.1158/0008-5472.CAN-06-0802.

CAS  Article  Google Scholar 

Wan Q, Du Z, Fang Z, Cheng H, Li C, Zhou X. Matrine induces apoptosis and autophagy in human lung adenocarcinoma cells via upregulation of Cavin3 and suppression of PI3K/AKT pathway. J BUON. 2020;25(3):1512–6.

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