The diverse functions of FAT1 in cancer progression: good, bad, or ugly?

Cramer JD, Burtness B, Le QT, Ferris RL. The changing therapeutic landscape of head and neck cancer. Nat Rev Clin Oncol. 2019;16(11):669–83. https://doi.org/10.1038/s41571-019-0227-z.

Article  PubMed  Google Scholar 

Leemans CR, Snijders PJF, Brakenhoff RH. The molecular landscape of head and neck cancer. Nat Rev Cancer. 2018;18(5):269–82. https://doi.org/10.1038/nrc.2018.11.

CAS  Article  PubMed  Google Scholar 

Cancer Genome Atlas N. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517(7536):576–82. https://doi.org/10.1038/nature14129.

CAS  Article  Google Scholar 

Campbell JD, Yau C, Bowlby R, Liu Y, Brennan K, Fan H, Taylor AM, Wang C, Walter V, Akbani R, Byers LA, Creighton CJ, Coarfa C, Shih J, Cherniack AD, Gevaert O, Prunello M, Shen H, Anur P, Chen J, Cheng H, Hayes DN, Bullman S, Pedamallu CS, Ojesina AI, Sadeghi S, Mungall KL, Robertson AG, Benz C, Schultz A, Kanchi RS, Gay CM, Hegde A, Diao L, Wang J, Ma W, Sumazin P, Chiu HS, Chen TW, Gunaratne P, Donehower L, Rader JS, Zuna R, Al-Ahmadie H, Lazar AJ, Flores ER, Tsai KY, Zhou JH, Rustgi AK, Drill E, Shen R, Wong CK, Cancer Genome Atlas Research N, Stuart JM, Laird PW, Hoadley KA, Weinstein JN, Peto M, Pickering CR, Chen Z, Van Waes C. Genomic, pathway network, and immunologic features distinguishing squamous carcinomas. Cell Rep. 2018;23(1):194–212. https://doi.org/10.1016/j.celrep.2018.03.063.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018;9(1):2372. https://doi.org/10.1038/s41467-018-04590-1.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Santos-de-Frutos K, Segrelles C, Lorz C. Hippo pathway and YAP signaling alterations in squamous cancer of the head and neck. J Clin Med. 2019;8(12):2131. https://doi.org/10.3390/jcm8122131.

CAS  Article  PubMed Central  Google Scholar 

Kim KT, Kim BS, Kim JH. Association between FAT1 mutation and overall survival in patients with human papillomavirus-negative head and neck squamous cell carcinoma. Head Neck. 2016;38(Suppl 1):E2021–9. https://doi.org/10.1002/hed.24372.

Article  PubMed  PubMed Central  Google Scholar 

Lin SC, Lin LH, Yu SY, Kao SY, Chang KW, Cheng HW, Liu CJ. FAT1 somatic mutations in head and neck carcinoma are associated with tumor progression and survival. Carcinogenesis. 2018;39(11):1320–30. https://doi.org/10.1093/carcin/bgy107.

CAS  Article  PubMed  Google Scholar 

Mann JE, Kulkarni A, Birkeland AC, Kafelghazal J, Eisenberg J, Jewell BM, Ludwig ML, Spector ME, Jiang H, Carey TE, Brenner JC. The molecular landscape of the University of Michigan laryngeal squamous cell carcinoma cell line panel. Head Neck. 2019;41(9):3114–24. https://doi.org/10.1002/hed.25803.

Article  PubMed  PubMed Central  Google Scholar 

Cheng H, Yang X, Si H, Saleh AD, Xiao W, Coupar J, Gollin SM, Ferris RL, Issaeva N, Yarbrough WG, Prince ME, Carey TE, Van Waes C, Chen Z. Genomic and transcriptomic characterization links cell lines with aggressive head and neck cancers. Cell Rep. 2018;25(5):1332 e5-1345. https://doi.org/10.1016/j.celrep.2018.10.007.

CAS  Article  Google Scholar 

Morris LG, Kaufman AM, Gong Y, Ramaswami D, Walsh LA, Turcan S, Eng S, Kannan K, Zou Y, Peng L, Banuchi VE, Paty P, Zeng Z, Vakiani E, Solit D, Singh B, Ganly I, Liau L, Cloughesy TC, Mischel PS, Mellinghoff IK, Chan TA. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet. 2013;45(3):253–61. https://doi.org/10.1038/ng.2538.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Brenner JC, Graham MP, Kumar B, Saunders LM, Kupfer R, Lyons RH, Bradford CR, Carey TE. Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010;32(4):417–26. https://doi.org/10.1002/hed.21198.

Article  PubMed  PubMed Central  Google Scholar 

Tanoue T, Takeichi M. New insights into Fat cadherins. J Cell Sci. 2005;118(Pt 11):2347–53. https://doi.org/10.1242/jcs.02398.

CAS  Article  PubMed  Google Scholar 

Bryant PJ, Huettner B, Held LI Jr, Ryerse J, Szidonya J. Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila. Dev Biol. 1988;129(2):541–54. https://doi.org/10.1016/0012-1606(88)90399-5.

CAS  Article  PubMed  Google Scholar 

Peng Z, Gong Y, Liang X. Role of FAT1 in health and disease. Oncol Lett. 2021;21(5):398. https://doi.org/10.3892/ol.2021.12659.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Lan T, Ge Q, Zheng K, Huang L, Yan Y, Zheng L, Lu Y, Zheng D. FAT1 upregulates in oral squamous cell carcinoma and promotes cell proliferation via cell cycle and DNA repair. Front Oncol. 2022;12:870055. https://doi.org/10.3389/fonc.2022.870055.

Article  PubMed  PubMed Central  Google Scholar 

Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, Da SM, Zhao Q, Beverley PC, Owen MJ. Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule. Genomics. 1995;30(2):207–23. https://doi.org/10.1006/geno.1995.9884.

CAS  Article  PubMed  Google Scholar 

Katoh Y, Katoh M. Comparative integromics on FAT1, FAT2, FAT3 and FAT4. Int J Mol Med. 2006;18(3):523–8. https://doi.org/10.3892/ijmm.18.3.523.

CAS  Article  PubMed  Google Scholar 

Sadeqzadeh E, de Bock CE, Zhang XD, Shipman KL, Scott NM, Song C, Yeadon T, Oliveira CS, Jin B, Hersey P, Boyd AW, Burns GF, Thorne RF. Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products. J Biol Chem. 2011;286(32):28181–91. https://doi.org/10.1074/jbc.M111.234419.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Cao LL, Riascos-Bernal DF, Chinnasamy P, Dunaway CM, Hou R, Pujato MA, O’Rourke BP, Miskolci V, Guo L, Hodgson L, Fiser A, Sibinga NE. Control of mitochondrial function and cell growth by the atypical cadherin Fat1. Nature. 2016;539(7630):575–8. https://doi.org/10.1038/nature20170.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Riascos-Bernal DF, Maira A, Sibinga NES. The atypical cadherin FAT1 limits mitochondrial respiration and proliferation of vascular smooth muscle cells. Front Cardiovasc Med. 2022;9: 905717. https://doi.org/10.3389/fcvm.2022.905717.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Hou R, Liu L, Anees S, Hiroyasu S, Sibinga NE. The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals. J Cell Biol. 2006;173(3):417–29. https://doi.org/10.1083/jcb.200508121.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Tanoue T, Takeichi M. Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J Cell Biol. 2004;165(4):517–28. https://doi.org/10.1083/jcb.200403006.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Saburi S, Hester I, Goodrich L, McNeill H. Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity. Development. 2012;139(10):1806–20. https://doi.org/10.1242/dev.077461.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Mahoney PA, Weber U, Onofrechuk P, Biessmann H, Bryant PJ, Goodman CS. The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell. 1991;67(5):853–68. https://doi.org/10.1016/0092-8674(91)90359-7.

CAS  Article  PubMed  Google Scholar 

Srivastava C, Irshad K, Gupta Y, Sarkar C, Suri A, Chattopadhyay P, Sinha S, Chosdol K. NFsmall ka, CyrillicB is a critical transcriptional regulator of atypical cadherin FAT1 in glioma. BMC Cancer. 2020;20(1):62. https://doi.org/10.1186/s12885-019-6435-1.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Wang G, Ma Y, Teng J, Wang Y, Cui Y, Dong Y, Shao S, Zhan Q, Liu X. FAT1, a direct transcriptional target of E2F1, suppresses cell proliferation, migration and invasion in esophageal squamous cell carcinoma. Chin J Cancer Res. 2019;31(4):609–19. https://doi.org/10.21147/j.issn.1000-9604.2019.04.05.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Pastushenko I, Mauri F, Song Y, de Cock F, Meeusen B, Swedlund B, Impens F, Van Haver D, Opitz M, Thery M, Bareche Y, Lapouge G, Vermeersch M, Van Eycke YR, Balsat C, Decaestecker C, Sokolow Y, Hassid S, Perez-Bustillo A, Agreda-Moreno B, Rios-Buceta L, Jaen P, Redondo P, Sieira-Gil R, Millan-Cayetano JF, Sanmatrtin O, D’Haene N, Moers V, Rozzi M, Blondeau J, Lemaire S, Scozzaro S, Janssens V, De Troya M, Dubois C, Perez-Morga D, Salmon I, Sotiriou C, Helmbacher F, Blanpain C. Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis. Nature. 2021;589(7842):448–55. https://doi.org/10.1038/s41586-020-03046-1.

CAS  Article  PubMed  Google Scholar 

Li M, Zhong Y, Wang M. Fat1 suppresses the tumor-initiating ability of nonsmall cell lung cancer cells by promoting Yes-associated protein 1 nuclear-cytoplasmic translocation. Environ Toxicol. 2021;36(11):2333–41. https://doi.org/10.1002/tox.23347.

CAS  Article  PubMed  Google Scholar 

Jiang S, Zhu Y, Chen Z, Huang Z, Liu B, Xu Y, Li Z, Lin Z, Li M. S100A14 inhibits cell growth and epithelial-mesenchymal transition (EMT) in prostate cancer through FAT1-mediated Hippo signaling pathway. Hum Cell. 2021;34(4):1215–26. https://doi.org/10.1007/s13577-021-00538-8.

CAS  Article  PubMed  Google Scholar 

Meng P, Zhang YF, Zhang W, Chen X, Xu T, Hu S, Liang X, Feng M, Yang X, Ho M. Identification of the atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells. Sci Rep. 2021;11(1):40. https://doi.org/10.1038/s41598-020-79524-3.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Hu X, Zhai Y, Kong P, Cui H,

留言 (0)

沒有登入
gif