Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy

Freeman C, Browne AM, Parish CR. Evidence that platelet and tumour heparanases are similar enzymes. Biochem J. 1990;342:361–8.

Article  Google Scholar 

Vlodavsky I, Friedmann Y. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest. 2001;108:341–7.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Nakajima M, Irimura T, Nicolson GL. Heparanases and tumor metastasis. J Cell Biochem. 1988;36:157–67.

CAS  PubMed  Article  Google Scholar 

Bashkin P, Razin E, Eldor A, Vlodavsky I. Degranulating mast cells secrete an endoglycosidase that degrades heparan sulfate in subendothelial extracellular matrix. Blood. 1990;75:2204–12.

CAS  PubMed  Article  Google Scholar 

Valentina M, Gianluigi Z, Maria FS, Giovanni G, Antonio L, Maurizio O. Heparanase is a key player in renal fibrosis by regulating TGF-β expression and activity. Biochim Biophys Acta. 2014;1843:2122–8.

Article  CAS  Google Scholar 

Valentina M, Giovanni G, Elena T, Anna MB, Alessandra G, Angela D’A, et al. Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells. J Biol Chem. 2012;287:1478–88.

Article  CAS  Google Scholar 

Shahid S, Caroline F, Simon D, Shahsoltan M, Genevieve C, Cynthia P, et al. The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma. Oncotarget. 2018;9:33778–87.

Article  Google Scholar 

Vlodavsky I, Ilan N, Naggi A, Casu B. Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate. Curr Pharm Des. 2007;13:2057–73.

CAS  PubMed  Article  Google Scholar 

Parish CR. The role of heparan sulphate in inflammation. Nat Rev Immunol. 2006;6:633–43.

CAS  PubMed  Article  Google Scholar 

Vlodavsky I, Singh P, Boyango I, Gutter-Kapon L, Elkin M, Sanderson RD, et al. Heparanase: from basic research to therapeutic applications in cancer and inflammation. Drug Resist Updat. 2016;29:54–75.

PubMed  PubMed Central  Article  Google Scholar 

Zhang GL, Gutter-Kapon L, Ilan N, Batool T, Singh K, Digre A, et al. Significance of host heparanase in promoting tumor growth and metastasis. Matrix Biol. 2020;93:25–42.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Bhattacharya U, Gutter-Kapon L, Kan T, Boyango I, Barash U, Yang SM, et al. Heparanase and chemotherapy synergize to drive macrophage activation and enhance tumor growth. Cancer Res. 2020;80:57–68.

CAS  PubMed  Article  Google Scholar 

Zetser A, Bashenko Y, Edovitsky E, Levy-Adam F, Vlodavsky I, Ilan N. Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src ac tivation. Cancer Res. 2006;66:1455–63.

CAS  PubMed  Article  Google Scholar 

Koganti R, Suryawanshi R, Shukla D. Heparanase, cell signaling, and viral infections. Cell Mol Life Sci. 2020;77:5059–77.

CAS  PubMed  PubMed Central  Article  Google Scholar 

He YQ, Sutcliffe EL, Bunting KL, Li J, Goodall KJ, Poon IK, et al. The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes. Transcription. 2012;3:130–45.

PubMed  PubMed Central  Article  Google Scholar 

Nadir Y, Brenner B, Zetser A, Ilan N, Shafat I, Zcharia E, et al. Heparanase induces tissue factor expression in vascular endothelial and cancer cells. J Thromb Haemost. 2006;4:2443–51.

CAS  PubMed  Article  Google Scholar 

Gingis-Velitski S, Zetser A, Flugelman MY, Vlodavsky I, Ilan N. Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem. 2004;279:23536–41.

CAS  PubMed  Article  Google Scholar 

Riaz A, Ilan N, Vlodavsky I, Li JP, Johansson S. Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence. J Biol Chem. 2013;288:12366–75.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Cohen-Kaplan V, Doweck I, Naroditsky I, Vlodavsky I, Ilan N. Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res. 2008;68:10077–85.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Cohen-Kaplan V, Jrbashyan J, Yanir Y, Naroditsky I, Ben-Izhak O, Ilan N, et al. Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer. J Biol Chem. 2021;287:6668–78.

Article  CAS  Google Scholar 

Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27–42.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tian X, Teng J, Chen J. New insights regarding SNARE proteins in autophagosome-lysosome fusion. Autophagy. 2021;17:2680–8.

CAS  PubMed  Article  Google Scholar 

Xia Y, Liu N, Xie X, Bi G, Ba H, Li L, et al. The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion. Autophagy. 2019;15:960–75.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kimmelman AC, White E. Autophagy and tumor metabolism. Cell Metab. 2017;25:1037–43.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Levine B, Kroemer G. Biological functions of autophagy genes: a disease perspective. Cell. 2019;176:11–42.

CAS  PubMed  PubMed Central  Article  Google Scholar 

White E, Mehnert JM, Chan CS. Autophagy, metabolism, and cancer. Clin Cancer Res. 2015;21:5037–46.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kumar S, Jain A, Choi SW, da Silva GPD, Allers L, Mudd MH, et al. Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens. Nat Cell Biol. 2020;22:973–85.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Guo H, Pu M, Tai Y, Chen Y, Lu H, Qiao J, et al. Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy. Cell Death Differ. 2021;28:320–36.

CAS  PubMed  Article  Google Scholar 

Li Y, Hodge J, Liu Q, Wang J, Wang Y, Evans TD, et al. TFEB is a master regulator of tumor-associated macrophages in breast cancer. J Immunother Cancer. 2020;8:e000543.

PubMed  PubMed Central  Article  Google Scholar 

Xiang H, Zhang J, Lin C, Zhang L, Liu B, Ouyang L. Targeting autophagy-related protein kinases for potential therapeutic purpose. Acta Pharm Sin B. 2020;10:569–81.

CAS  PubMed  Article  Google Scholar 

He R, Wang M, Zhao C, Shen M, Yu Y, He L, et al. TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells. J Exp Clin Cancer Res. 2019;38:340.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Shteingauz A, Boyango I, Naroditsky I, Hammond E, Gruber M, Doweck I, et al. Heparanase enhances tumor growth and chemoresistance by promoting autophagy. Cancer Res. 2015;75:3946–57.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Dredge K, Hammond E, Handley P, Gonda TJ, Smith MT, Vincent C, et al. PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Br J Cancer. 2011;104:635–42.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Yang M, Pi H, Li M, Xu S, Zhang L, Xie J, et al. From the cover: autophagy induction contributes to cadmium toxicity in mesenchymal stem cells via AMPK/FOXO3a/BECN1 signaling. Toxicol Sci. 2016;154:101–14.

CAS  PubMed  Article  Google Scholar 

Meacham CE, Morrison SJ. Tumour heterogeneity and cancer cell plasticity. Nature. 2013;501:328–37.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Barash U, Cohen-Kaplan V, Arvatz G, Gingis-Velitski S, Levy-Adam F, Nativ O, et al. A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics. FASEB J. 2010;24:1239–48.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zetser A, Bashenko Y, Miao HQ, Vlodavsky I, Ilan N. Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res. 2003;63:7733–41.

CAS  PubMed  Google Scholar 

Poillet-Perez L, White E. Role of tumor and host autophagy in cancer metabolism. Genes Dev. 2019;33:610–9.

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