Mitochondrial quality control in cardiac ischemia/reperfusion injury: new insights into mechanisms and implications

Adaniya SM, O-uchi J, Cypress MW, Kusakari Y, Jhun BS. Posttranslational modifications of mitochondrial fission and fusion proteins in cardiac physiology and pathophysiology. Am J Physiol Cell Physiol. 2019;C316:C583–604. https://doi.org/10.1152/ajpcell.00523.2018.

CAS  Article  Google Scholar 

Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, et al. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem. 2005;280:19587–93. https://doi.org/10.1074/jbc.M408862200.

CAS  Article  PubMed  Google Scholar 

Anzell AR, Maizy R, Przyklenk K, Sanderson TH. Mitochondrial quality control and disease: insights into ischemia-reperfusion injury. Mol Neurobiol. 2018;55:2547–64. https://doi.org/10.1007/s12035-017-0503-9.

CAS  Article  PubMed  Google Scholar 

Baetz D, Regula KM, Ens K, Shaw J, Kothari S, Yurkova N, et al. Nuclear factor-kappaB-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes. Circulation. 2005;112:3777–85. https://doi.org/10.1161/circulationaha.105.573899.

CAS  Article  PubMed  Google Scholar 

Bai Y, Yang Y, Gao Y, Lin D, Wang Z, Ma J. Melatonin postconditioning ameliorates anoxia/reoxygenation injury by regulating mitophagy and mitochondrial dynamics in a SIRT3-dependent manner. Eur J Pharmacol. 2021;904: 174157. https://doi.org/10.1016/j.ejphar.2021.174157.

CAS  Article  PubMed  Google Scholar 

Bi W, Jia J, Pang R, Nie C, Han J, Ding Z, et al. Thyroid hormone postconditioning protects hearts from ischemia/reperfusion through reinforcing mitophagy. Biomed Pharmacother. 2019;118: 109220. https://doi.org/10.1016/j.biopha.2019.109220.

CAS  Article  PubMed  Google Scholar 

Bian X, Xu J, Zhao H, Zheng Q, Xiao X, Ma X, et al. Zinc-induced SUMOylation of dynamin-related protein 1 protects the heart against ischemia-reperfusion injury. Oxid Med Cell Longev. 2019;2019:1232146. https://doi.org/10.1155/2019/1232146.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci U S A. 2011;108:9572–7. https://doi.org/10.1073/pnas.1106291108.

Article  PubMed  PubMed Central  Google Scholar 

Brand CS, Tan VP, Brown JH, Miyamoto S. RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes. Cell Signal. 2018;50:48–57. https://doi.org/10.1016/j.cellsig.2018.06.012.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Burke N, Hall AR, Hausenloy DJ. OPA1 in cardiovascular health and disease. Curr Drug Targets. 2015;16:912–20. https://doi.org/10.2174/1389450116666150102113648.

CAS  Article  PubMed  Google Scholar 

Cao S, Sun Y, Wang W, Wang B, Zhang Q, Pan C, et al. Poly (ADP-ribose) polymerase inhibition protects against myocardial ischaemia/reperfusion injury via suppressing mitophagy. J Cell Mol Med. 2019;23:6897–906. https://doi.org/10.1111/jcmm.14573.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008;14:193–204. https://doi.org/10.1016/j.devcel.2007.11.019.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chen Z, Liu L, Cheng Q, Li Y, Wu H, Zhang W, et al. Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy. EMBO Rep. 2017; 18: 495–509. https://doi.org/10.15252/embr.201643309.

Chen L, Gong Q, Stice JP, Knowlton AA. Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res. 2009;84:91–9. https://doi.org/10.1093/cvr/cvp181.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chen L, Chen XY, Wang QL, Yang SJ, Zhou H, Ding LS, et al. Astragaloside IV Derivative (LS-102) alleviated myocardial ischemia reperfusion injury by inhibiting Drp1(Ser616) phosphorylation-mediated mitochondrial fission. Front Pharmacol. 2020;11:1083. https://doi.org/10.3389/fphar.2020.01083.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Dorn GW 2nd. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science. 2013;340:471–5. https://doi.org/10.1126/science.1231031.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, et al. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012;1: e003012. https://doi.org/10.1161/jaha.112.003012.

Article  PubMed  PubMed Central  Google Scholar 

Chen G, Han Z, Feng D, Chen Y, Chen L, Wu H, et al. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Mol Cell. 2014;54:362–77. https://doi.org/10.1016/j.molcel.2014.02.034.

CAS  Article  PubMed  Google Scholar 

Cogliati S, Frezza C, Soriano ME, Varanita T, Quintana-Cabrera R, Corrado M, et al. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013;155:160–71. https://doi.org/10.1016/j.cell.2013.08.032.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Czubryt MP, McAnally J, Fishman GI, Olson EN. Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci USA. 2003;100:1711–6. https://doi.org/10.1073/pnas.0337639100.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Datta Chaudhuri R, Banik A, Mandal B, Sarkar S. Cardiac-specific overexpression of HIF-1α during acute myocardial infarction ameliorates cardiomyocyte apoptosis via differential regulation of hypoxia-inducible pro-apoptotic and anti-oxidative genes. Biochem Biophys Res Commun. 2021;537:100–8. https://doi.org/10.1016/j.bbrc.2020.12.084.

CAS  Article  PubMed  Google Scholar 

Deng P, Haynes CM. Mitochondrial dysfunction in cancer: potential roles of ATF5 and the mitochondrial UPR. Semin Cancer Biol. 2017;47:43–9. https://doi.org/10.1016/j.semcancer.2017.05.002.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Dhingra R, Margulets V, Chowdhury SR, Thliveris J, Jassal D, Fernyhough P, et al. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Proc Natl Acad Sci USA. 2014;111:E5537–44. https://doi.org/10.1073/pnas.1414665111.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Din S, Mason M, Völkers M, Johnson B, Cottage CT, Wang Z, et al. Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation. Proc Natl Acad Sci USA. 2013;110:5969–74. https://doi.org/10.1073/pnas.1213294110.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Ding Q, Qi Y, Tsang SY. Mitochondrial biogenesis, mitochondrial dynamics, and mitophagy in the maturation of cardiomyocytes. Cells. 2021;10. https://doi.org/10.3390/cells10092463.

Dorn GW 2nd. Parkin-dependent mitophagy in the heart. J Mol Cell Cardiol. 2016;95:42–9. https://doi.org/10.1016/j.yjmcc.2015.11.023.

CAS  Article  PubMed  Google Scholar 

Fernandez-Marcos PJ, Auwerx J. Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr. 2011;93:884s-s890. https://doi.org/10.3945/ajcn.110.001917.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, et al. A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun. 2019;10:329. https://doi.org/10.1038/s41467-018-08276-6.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gao L, Zhao Y, He J, Yan Y, Xu L, Lin N, et al. The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury. J Genet Genomics. 2018;45:125–35. https://doi.org/10.1016/j.jgg.2017.12.002.

Article  PubMed  Google Scholar 

Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet. 2010;19:4861–70. https://doi.org/10.1093/hmg/ddq419.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Geisler S, Holmström KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol. 2010;12:119–31. https://doi.org/10.1038/ncb2012.

CAS  Article  PubMed  Google Scholar 

Griffiths EJ, Halestrap AP. Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J. 1995;307(Pt 1):93–8. https://doi.org/10.1042/bj3070093.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, et al. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020;579:427–32. https://doi.org/10.1038/s41586-020-2078-2.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gustafsson AB. Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium. Pediatr Cardiol. 2011;32:267–74. https://doi.org/10.1007/s00246-010-9876-5.

Article  PubMed  PubMed Central  Google Scholar 

Hall AR, Burke N, Dongworth RK, Kalkhoran SB, Dyson A, Vicencio JM, et al. Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction. Cell Death Dis. 2016;7: e2238. https://doi.org/10.1038/cddis.2016.139.

CAS  Article  PubMed  PubMed Central 

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