The structure-specific endonuclease complex SLX4–XPF regulates Tus–Ter-induced homologous recombination

Berti, M., Cortez, D. & Lopes, M. The plasticity of DNA replication forks in response to clinically relevant genotoxic stress. Nat. Rev. Mol. Cell Biol. 21, 633–651 (2020).

CAS  PubMed  Article  Google Scholar 

Cortez, D. Replication-coupled DNA repair. Mol. Cell 74, 866–876 (2019).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Quinet, A., Tirman, S., Cybulla, E., Meroni, A. & Vindigni, A. To skip or not to skip: choosing repriming to tolerate DNA damage. Mol. Cell 81, 649–658 (2021).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Crossley, M. P., Bocek, M. & Cimprich, K. A. R-loops as cellular regulators and genomic threats. Mol. Cell 73, 398–411 (2019).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Semlow, D. R., Zhang, J., Budzowska, M., Drohat, A. C. & Walter, J. C. Replication-dependent unhooking of DNA interstrand cross-links by the NEIL3 glycosylase. Cell 167, 498–511.e14 (2016).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hodskinson, M. R. et al. Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms. Nature 579, 603–608 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Huang, J. et al. The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks. Mol. Cell 52, 434–446 (2013).

CAS  PubMed  Article  Google Scholar 

Huang, J. et al. Remodeling of interstrand crosslink proximal replisomes is dependent on ATR, FANCM, and FANCD2. Cell Rep. 27, 1794–1808.e5 (2019).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Semlow, D. R. & Walter, J. C. Mechanisms of vertebrate DNA interstrand cross-link repair. Annu. Rev. Biochem. 90, 107–135 (2021).

CAS  PubMed  Article  Google Scholar 

Niraj, J., Färkkilä, A. & D’Andrea, A. D. The fanconi anemia pathway in Cancer. Annu. Rev. Cancer Biol. 3, 457–478 (2019).

PubMed  Article  Google Scholar 

Taylor, A. M. R. et al. Chromosome instability syndromes. Nat. Rev. Dis. Primers 5, 64 (2019).

PubMed  Article  Google Scholar 

Garaycoechea, J. I. et al. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature 553, 171–177 (2018).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Langevin, F., Crossan, G. P., Rosado, I. V., Arends, M. J. & Patel, K. J. Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 475, 53–58 (2011).

CAS  PubMed  Article  Google Scholar 

Rosado, I. V., Langevin, F., Crossan, G. P., Takata, M. & Patel, K. J. Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Nat. Struct. Mol. Biol. 18, 1432–1434 (2011).

CAS  PubMed  Article  Google Scholar 

O’Brien, P. J., Siraki, A. G. & Shangari, N. Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health. Crit. Rev. Toxicol. 35, 609–662 (2005).

PubMed  Article  CAS  Google Scholar 

Raschle, M. et al. Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134, 969–980 (2008).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wu, R. A. et al. TRAIP is a master regulator of DNA interstrand crosslink repair. Nature 567, 267–272 (2019).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wang, S., Wang, R., Peralta, C., Yaseen, A. & Pavletich, N. P. Structure of the FA core ubiquitin ligase closing the ID clamp on DNA. Nat. Struct. Mol. Biol. 28, 300–309 (2021).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shakeel, S. et al. Structure of the Fanconi anaemia monoubiquitin ligase complex. Nature 575, 234–237 (2019).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Xue, X., Sung, P. & Zhao, X. Functions and regulation of the multitasking FANCM family of DNA motor proteins. Genes Dev. 29, 1777–1788 (2015).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Alcón, P. et al. FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair. Nat. Struct. Mol. Biol. 27, 240–248 (2020).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Tan, W. et al. Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays. eLife 9, e54128 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Amunugama, R. et al. Replication fork reversal during DNA interstrand crosslink repair requires CMG unloading. Cell Rep. 23, 3419–3428 (2018).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kim, Y. et al. Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. Blood 121, 54–63 (2013).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Klein Douwel, D. et al. XPF-ERCC1 acts in unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4. Mol. Cell 54, 460–471 (2014).

CAS  PubMed  Article  Google Scholar 

Bogliolo, M. et al. Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. Am. J. Hum. Genet. 92, 800–806 (2013).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Marín, M. et al. Functional comparison of XPF missense mutations associated to multiple DNA repair disorders. Genes 10, 60 (2019).

PubMed Central  Article  CAS  Google Scholar 

Hodskinson, M. R. et al. Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. Mol. Cell 54, 472–484 (2014).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Manandhar, M., Boulware, K. S. & Wood, R. D. The ERCC1 and ERCC4 (XPF) genes and gene products. Gene 569, 153–161 (2015).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhang, J. & Walter, J. C. Mechanism and regulation of incisions during DNA interstrand cross-link repair. DNA Repair 19, 135–142 (2014).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Duxin, J. P. & Walter, J. C. What is the DNA repair defect underlying Fanconi anemia? Curr. Opin. Cell Biol. 37, 49–60 (2015).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Willis, N. A. et al. BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks. Nature 510, 556–559 (2014).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Willis, N. A. et al. Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature 551, 590–595 (2017).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Nik-Zainal, S. et al. Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature 534, 47–54 (2016).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Menghi, F. et al. The tandem duplicator phenotype is a prevalent genome-wide cancer configuration driven by distinct gene mutations. Cancer Cell 34, 197–210.e5 (2018).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Scully, R., Panday, A., Elango, R. & Willis, N. A. DNA double-strand break repair-pathway choice in somatic mammalian cells. Nat. Rev. Mol. Cell Biol. 20, 698–714 (2019).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Panday, A. et al. FANCM regulates repair pathway choice at stalled replication forks. Mol. Cell. 81, 2428–2444.e6 (2021).

CAS  PubMed  PubMed Central  Article 

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