Berti, M., Cortez, D. & Lopes, M. The plasticity of DNA replication forks in response to clinically relevant genotoxic stress. Nat. Rev. Mol. Cell Biol. 21, 633–651 (2020).
CAS PubMed Article Google Scholar
Cortez, D. Replication-coupled DNA repair. Mol. Cell 74, 866–876 (2019).
CAS PubMed PubMed Central Article Google Scholar
Quinet, A., Tirman, S., Cybulla, E., Meroni, A. & Vindigni, A. To skip or not to skip: choosing repriming to tolerate DNA damage. Mol. Cell 81, 649–658 (2021).
CAS PubMed PubMed Central Article Google Scholar
Crossley, M. P., Bocek, M. & Cimprich, K. A. R-loops as cellular regulators and genomic threats. Mol. Cell 73, 398–411 (2019).
CAS PubMed PubMed Central Article Google Scholar
Semlow, D. R., Zhang, J., Budzowska, M., Drohat, A. C. & Walter, J. C. Replication-dependent unhooking of DNA interstrand cross-links by the NEIL3 glycosylase. Cell 167, 498–511.e14 (2016).
CAS PubMed PubMed Central Article Google Scholar
Hodskinson, M. R. et al. Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms. Nature 579, 603–608 (2020).
CAS PubMed PubMed Central Article Google Scholar
Huang, J. et al. The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks. Mol. Cell 52, 434–446 (2013).
CAS PubMed Article Google Scholar
Huang, J. et al. Remodeling of interstrand crosslink proximal replisomes is dependent on ATR, FANCM, and FANCD2. Cell Rep. 27, 1794–1808.e5 (2019).
CAS PubMed PubMed Central Article Google Scholar
Semlow, D. R. & Walter, J. C. Mechanisms of vertebrate DNA interstrand cross-link repair. Annu. Rev. Biochem. 90, 107–135 (2021).
CAS PubMed Article Google Scholar
Niraj, J., Färkkilä, A. & D’Andrea, A. D. The fanconi anemia pathway in Cancer. Annu. Rev. Cancer Biol. 3, 457–478 (2019).
Taylor, A. M. R. et al. Chromosome instability syndromes. Nat. Rev. Dis. Primers 5, 64 (2019).
Garaycoechea, J. I. et al. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature 553, 171–177 (2018).
CAS PubMed PubMed Central Article Google Scholar
Langevin, F., Crossan, G. P., Rosado, I. V., Arends, M. J. & Patel, K. J. Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 475, 53–58 (2011).
CAS PubMed Article Google Scholar
Rosado, I. V., Langevin, F., Crossan, G. P., Takata, M. & Patel, K. J. Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Nat. Struct. Mol. Biol. 18, 1432–1434 (2011).
CAS PubMed Article Google Scholar
O’Brien, P. J., Siraki, A. G. & Shangari, N. Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health. Crit. Rev. Toxicol. 35, 609–662 (2005).
PubMed Article CAS Google Scholar
Raschle, M. et al. Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134, 969–980 (2008).
CAS PubMed PubMed Central Article Google Scholar
Wu, R. A. et al. TRAIP is a master regulator of DNA interstrand crosslink repair. Nature 567, 267–272 (2019).
CAS PubMed PubMed Central Article Google Scholar
Wang, S., Wang, R., Peralta, C., Yaseen, A. & Pavletich, N. P. Structure of the FA core ubiquitin ligase closing the ID clamp on DNA. Nat. Struct. Mol. Biol. 28, 300–309 (2021).
CAS PubMed PubMed Central Article Google Scholar
Shakeel, S. et al. Structure of the Fanconi anaemia monoubiquitin ligase complex. Nature 575, 234–237 (2019).
CAS PubMed PubMed Central Article Google Scholar
Xue, X., Sung, P. & Zhao, X. Functions and regulation of the multitasking FANCM family of DNA motor proteins. Genes Dev. 29, 1777–1788 (2015).
CAS PubMed PubMed Central Article Google Scholar
Alcón, P. et al. FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair. Nat. Struct. Mol. Biol. 27, 240–248 (2020).
PubMed PubMed Central Article CAS Google Scholar
Tan, W. et al. Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays. eLife 9, e54128 (2020).
CAS PubMed PubMed Central Article Google Scholar
Amunugama, R. et al. Replication fork reversal during DNA interstrand crosslink repair requires CMG unloading. Cell Rep. 23, 3419–3428 (2018).
CAS PubMed PubMed Central Article Google Scholar
Kim, Y. et al. Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. Blood 121, 54–63 (2013).
CAS PubMed PubMed Central Article Google Scholar
Klein Douwel, D. et al. XPF-ERCC1 acts in unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4. Mol. Cell 54, 460–471 (2014).
CAS PubMed Article Google Scholar
Bogliolo, M. et al. Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia. Am. J. Hum. Genet. 92, 800–806 (2013).
CAS PubMed PubMed Central Article Google Scholar
Marín, M. et al. Functional comparison of XPF missense mutations associated to multiple DNA repair disorders. Genes 10, 60 (2019).
PubMed Central Article CAS Google Scholar
Hodskinson, M. R. et al. Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. Mol. Cell 54, 472–484 (2014).
CAS PubMed PubMed Central Article Google Scholar
Manandhar, M., Boulware, K. S. & Wood, R. D. The ERCC1 and ERCC4 (XPF) genes and gene products. Gene 569, 153–161 (2015).
CAS PubMed PubMed Central Article Google Scholar
Zhang, J. & Walter, J. C. Mechanism and regulation of incisions during DNA interstrand cross-link repair. DNA Repair 19, 135–142 (2014).
CAS PubMed PubMed Central Article Google Scholar
Duxin, J. P. & Walter, J. C. What is the DNA repair defect underlying Fanconi anemia? Curr. Opin. Cell Biol. 37, 49–60 (2015).
CAS PubMed PubMed Central Article Google Scholar
Willis, N. A. et al. BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks. Nature 510, 556–559 (2014).
CAS PubMed PubMed Central Article Google Scholar
Willis, N. A. et al. Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature 551, 590–595 (2017).
CAS PubMed PubMed Central Article Google Scholar
Nik-Zainal, S. et al. Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature 534, 47–54 (2016).
CAS PubMed PubMed Central Article Google Scholar
Menghi, F. et al. The tandem duplicator phenotype is a prevalent genome-wide cancer configuration driven by distinct gene mutations. Cancer Cell 34, 197–210.e5 (2018).
CAS PubMed PubMed Central Article Google Scholar
Scully, R., Panday, A., Elango, R. & Willis, N. A. DNA double-strand break repair-pathway choice in somatic mammalian cells. Nat. Rev. Mol. Cell Biol. 20, 698–714 (2019).
CAS PubMed PubMed Central Article Google Scholar
Panday, A. et al. FANCM regulates repair pathway choice at stalled replication forks. Mol. Cell. 81, 2428–2444.e6 (2021).
留言 (0)