Yang, J. et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. 21, 341–352 (2020).
PubMed PubMed Central Article CAS Google Scholar
Kalluri, R. & Weinberg, R. A. The basics of epithelial–mesenchymal transition. J. Clin. Invest. 119, 1420–1428 (2009).
CAS PubMed PubMed Central Article Google Scholar
Burger, G. A., Danen, E. H. J. & Beltman, J. B. Deciphering epithelial–mesenchymal transition regulatory networks in cancer through computational approaches. Front. Oncol. 7, 162–162 (2017).
PubMed PubMed Central Article Google Scholar
De Craene, B. & Berx, G. Regulatory networks defining EMT during cancer initiation and progression. Nat. Rev. Cancer 13, 97–110 (2013).
PubMed Article CAS Google Scholar
Braunschweig, U., Gueroussov, S., Plocik, A. M., Graveley, B. R. & Blencowe, B. J. Dynamic integration of splicing within gene regulatory pathways. Cell 152, 1252–1269 (2013).
CAS PubMed PubMed Central Article Google Scholar
Warzecha, C. C. et al. An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J. 29, 3286–3300 (2010).
CAS PubMed PubMed Central Article Google Scholar
Shapiro, I. M. et al. An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet. 7, e1002218 (2011).
CAS PubMed PubMed Central Article Google Scholar
Pillman, K. A. et al. miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking. EMBO J. 37, e99016 (2018).
PubMed PubMed Central Article CAS Google Scholar
Luco, R. F., Allo, M., Schor, I. E., Kornblihtt, A. R. & Misteli, T. Epigenetics in alternative pre-mRNA splicing. Cell 144, 16–26 (2011).
CAS PubMed PubMed Central Article Google Scholar
Brody, Y. et al. The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing. PLoS Biol. 9, e1000573 (2011).
CAS PubMed PubMed Central Article Google Scholar
Saldi, T., Cortazar, M. A., Sheridan, R. M. & Bentley, D. L. Coupling of RNA polymerase II transcription elongation with pre-mRNA splicing. J. Mol. Biol. 428, 2623–2635 (2016).
CAS PubMed PubMed Central Article Google Scholar
Schmitges, F. W. et al. Multiparameter functional diversity of human C2H2 zinc finger proteins. Genome Res. 26, 1742–1752 (2016).
CAS PubMed PubMed Central Article Google Scholar
Conomos, D., Reddel, R. R. & Pickett, H. A. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nat. Struct. Mol. Biol. 21, 760–770 (2014).
CAS PubMed Article Google Scholar
Yang, S. F., Sun, A. A., Shi, Y., Li, F. & Pickett, H. A. Structural and functional characterization of the RBBP4–ZNF827 interaction and its role in NuRD recruitment to telomeres. Biochem. J. 475, 2667–2679 (2018).
CAS PubMed Article Google Scholar
Sahu, S. K. et al. JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J. 34, 2162–2181 (2015).
CAS PubMed PubMed Central Article Google Scholar
Janda, E. et al. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J. Cell Biol. 156, 299–313 (2002).
CAS PubMed PubMed Central Article Google Scholar
Iorns, E. et al. A new mouse model for the study of human breast cancer metastasis. PLoS ONE 7, e47995 (2012).
CAS PubMed PubMed Central Article Google Scholar
Tang, Z. et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45, W98–W102 (2017).
CAS PubMed PubMed Central Article Google Scholar
Yan, Z. et al. OSbrca: a web server for breast cancer prognostic biomarker investigation with massive data from tens of cohorts. Front. Oncol. 9, 1349 (2019).
PubMed PubMed Central Article Google Scholar
Camargo Ortega, G. et al. The centrosome protein AKNA regulates neurogenesis via microtubule organization. Nature 567, 113–117 (2019).
CAS PubMed Article Google Scholar
Bibel, M., Richter, J., Lacroix, E. & Barde, Y. A. Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells. Nat. Protoc. 2, 1034–1043 (2007).
CAS PubMed Article Google Scholar
Telley, L. et al. Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex. Science 351, 1443–1446 (2016).
CAS PubMed Article Google Scholar
Saito, T. In vivo electroporation in the embryonic mouse central nervous system. Nat. Protoc. 1, 1552–1558 (2006).
CAS PubMed Article Google Scholar
Najafabadi, H. S. et al. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat. Biotechnol. 33, 555–562 (2015).
CAS PubMed Article Google Scholar
Mani, S. A. et al. The epithelial–mesenchymal transition generates cells with properties of stem cells. Cell 133, 704–715 (2008).
CAS PubMed PubMed Central Article Google Scholar
Kaya-Okur, H. S. et al. CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nat. Commun. 10, 1930 (2019).
PubMed PubMed Central Article CAS Google Scholar
Bulyk, M. L., Huang, X., Choo, Y. & Church, G. M. Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proc. Natl Acad. Sci. USA 98, 7158–7163 (2001).
CAS PubMed PubMed Central Article Google Scholar
Persikov, A. V. et al. A systematic survey of the Cys2His2 zinc finger DNA-binding landscape. Nucleic Acids Res. 43, 1965–1984 (2015).
CAS PubMed PubMed Central Article Google Scholar
Xia, B. et al. NR2F2 plays a major role in insulin-induced epithelial–mesenchymal transition in breast cancer cells. BMC Cancer 20, 626 (2020).
CAS PubMed PubMed Central Article Google Scholar
Han, H. et al. Multilayered control of alternative splicing regulatory networks by transcription factors. Mol. Cell 65, 539–553 e537 (2017).
CAS PubMed Article Google Scholar
Nieto, M. A., Huang, R. Y., Jackson, R. A. & Thiery, J. P. Emt: 2016. Cell 166, 21–45 (2016).
CAS PubMed Article Google Scholar
Li, J. et al. An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer. eLife 7, e37184 (2018).
PubMed PubMed Central Article Google Scholar
Yang, Y. et al. Determination of a comprehensive alternative splicing regulatory network and combinatorial regulation by key factors during the epithelial-to-mesenchymal transition. Mol. Cell Biol. 36, 1704–1719 (2016).
CAS PubMed PubMed Central Article Google Scholar
Conn, S. J. et al. The RNA binding protein quaking regulates formation of circRNAs. Cell 160, 1125–1134 (2015).
CAS PubMed Article Google Scholar
Fong, N. et al. Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate. Genes Dev. 28, 2663–2676 (2014).
PubMed PubMed Central Article Google Scholar
Barbieri, E. et al. Rapid and scalable profiling of nascent RNA with fastGRO. Cell Rep. 33, 108373 (2020).
CAS PubMed PubMed Central Article Google Scholar
Singh, J. & Padgett, R. A. Rates of in situ transcription and splicing in large human genes. Nat. Struct. Mol. Biol. 16, 1128–1133 (2009).
CAS PubMed PubMed Central Article Google Scholar
Mrkvicova, A. et
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