Untangling the web of intratumour heterogeneity

Vendramin, R., Litchfield, K. & Swanton, C. Cancer evolution: Darwin and beyond. EMBO J. 40, e108389 (2021).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Marine, J. C., Dawson, S. J. & Dawson, M. A. Non-genetic mechanisms of therapeutic resistance in cancer. Nat. Rev. Cancer 20, 743–756 (2020).

CAS  PubMed  Article  Google Scholar 

Tomasetti, C. & Vogelstein, B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347, 78–81 (2015).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wang, R. et al. Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma. Nat. Med. 27, 141–151 (2021).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Best, S. A. et al. Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. Nat. Commun. 10, 4190 (2019).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Baggiolini, A. et al. Developmental chromatin programs determine oncogenic competence in melanoma. Science 373, eabc1048 (2021).

CAS  PubMed  Article  Google Scholar 

Concepcion, C. P. et al. Smarca4 inactivation promotes lineage-specific transformation and early metastatic features in the lung. Cancer Discov. 12, 562–585 (2022).

CAS  PubMed  Article  Google Scholar 

Chetty, R. & Serra, S. SMARCA family of genes. J. Clin. Pathol. 73, 257–260 (2020).

CAS  PubMed  Article  Google Scholar 

Marjanovic, N. D. et al. Emergence of a high-plasticity cell state during lung cancer evolution. Cancer Cell 38, 229–246.e13 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Risom, T. et al. Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer. Nat. Commun. 9, 3815 (2018).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Negrini, S., Gorgoulis, V. G. & Halazonetis, T. D. Genomic instability—an evolving hallmark of cancer. Nat. Rev. Mol. Cell Biol. 11, 220–228 (2010).

CAS  PubMed  Article  Google Scholar 

Tubbs, A. & Nussenzweig, A. Endogenous DNA damage as a source of genomic instability in cancer. Cell 168, 644–656 (2017).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ross, J. et al. Targeting MYC: from understanding its biology to drug discovery. Eur. J. Med. Chem. 213, 113137 (2021).

CAS  PubMed  Article  Google Scholar 

Roider, T. et al. Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels. Nat. Cell Biol. 22, 896–906 (2020).

CAS  PubMed  Article  Google Scholar 

Maddipati, R. et al. MYC levels regulate metastatic heterogeneity in pancreatic adenocarcinoma. Cancer Discov. 12, 542–561 (2022).

CAS  PubMed  Article  Google Scholar 

Tirier, S. M. et al. Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics. Nat. Commun. 12, 6960 (2021).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bakhoum, S. F. & Landau, D. A. Chromosomal instability as a driver of tumor heterogeneity and evolution. Cold Spring Harb. Perspect. Med. 7, a029611 (2017).

PubMed  PubMed Central  Article  CAS  Google Scholar 

van Dijk, E. et al. Chromosomal copy number heterogeneity predicts survival rates across cancers. Nat. Commun. 12, 3188 (2021).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Hinohara, K. & Polyak, K. Intratumoral heterogeneity: more than just mutations. Trends Cell Biol. 29, 569–579 (2019).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hinohara, K. et al. KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance. Cancer Cell 34, 939–953.e9 (2018).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sharma, S. V. et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141, 69–80 (2010).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hu, X., Biswas, A. & De, S. KMT2C deficiency promotes APOBEC mutagenesis and genomic instability in multiple cancers. Preprint at bioRxiv https://doi.org/10.1101/2022.02.04.478993 (2022).

Meir, Z., Mukamel, Z., Chomsky, E., Lifshitz, A. & Tanay, A. Single-cell analysis of clonal maintenance of transcriptional and epigenetic states in cancer cells. Nat. Genet. 52, 709–718 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fennell, K. A. et al. Non-genetic determinants of malignant clonal fitness at single-cell resolution. Nature 601, 125–131 (2022).

CAS  PubMed  Article  Google Scholar 

Cejas, P. et al. Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer. Nat. Commun. 12, 5775 (2021).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Baron, M. et al. The stress-like cancer cell state is a consistent component of tumorigenesis. Cell Syst. 11, 536–546.e7 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rutherford, S. L. & Lindquist, S. Hsp90 as a capacitor for morphological evolution. Nature 396, 336–342 (1998).

CAS  PubMed  Article  Google Scholar 

Gaglia, G. et al. HSF1 phase transition mediates stress adaptation and cell fate decisions. Nat. Cell Biol. 22, 151–158 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Campbell, N. R. et al. Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation. Dev. Cell 56, 2808–2825.e10 (2021).

CAS  PubMed  Article  Google Scholar 

Laconi, E., Marongiu, F. & DeGregori, J. Cancer as a disease of old age: changing mutational and microenvironmental landscapes. Br. J. Cancer 122, 943–952 (2020).

PubMed  PubMed Central  Article  Google Scholar 

Li, C. M.-C. et al. Aging-associated alterations in mammary epithelia and stroma revealed by single-cell RNA sequencing. Cell Rep. 33, 108566 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Pradhan, R. N., Krishnamurty, A. T., Fletcher, A. L., Turley, S. J. & Muller, S. A bird’s eye view of fibroblast heterogeneity: a pan-disease, pan-cancer perspective. Immunol. Rev. 302, 299–320 (2021).

CAS  PubMed  Article  Google Scholar 

Costa, A. et al. Fibroblast heterogeneity and immunosuppressive environment in human breast cancer. Cancer Cell 33, 463–479.e10 (2018).

CAS  PubMed  Article  Google Scholar 

Pelon, F. et al. Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms. Nat. Commun. 11, 404 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tissot, T. et al. Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems? Biochim. Biophys. Acta 1865, 147–154 (2016).

CAS  PubMed  Google Scholar 

Sun, Y.-F. et al. Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma. Nat. Commun. 12, 4091 (2021).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Piersma, B., Hayward, M. K. & Weaver, V. M. Fibrosis and cancer: a strained relationship. Biochim. Biophys. Acta Rev. Cancer 1873, 188356 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Madan, E. et al. Cell competition boosts clonal evolution and hypoxic selection in cancer. Trends Cell Biol. 30, 967–978 (2020).

CAS  PubMed  Article  Google Scholar 

Zaidi, M., Fu, F., Cojocari, D., McKee, T. D. & Wouters, B. G. Quantitative visualization of hypoxia and proliferation gradients within histological tissue sections. Front. Bioeng. Biotechnol. 7, 397 (2019).

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