Fluid and White Matter Suppression: New Sensitive 3 T Magnetic Resonance Imaging Contrasts for Cortical Lesion Detection in Multiple Sclerosis

From the ∗Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel

†Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel

‡Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne

§CIBM Center for Biomedical Imaging, Lausanne, Switzerland

∥Univ Rennes, Inserm, LTSI-UMR1099, Rennes, France

¶The Australian e-Health Research Centre, CSIRO, Brisbane, Australia

#Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel

∗∗Radiology Department, Lausanne University and University Hospital, Lausanne, Switzerland.

Received for publication January 2, 2022; and accepted for publication, after revision, February 26, 2022.

Conflicts of interest and sources of funding: J.M., F.L.R., J.B., C.T., R.R., M.B.C., and G.G. have nothing to disclose. M.W. is partially funded by Biogen for the development of spinal cord magnetic resonance imaging for patients with spinal muscular atrophy. The University Hospital Basel, as the employer of C.G., has received the following fees, which were used exclusively for research support: (1) advisory board and consultancy fees from Actelion, Genzyme-Sanofi, Novartis, GeNeuro, and Roche; (2) speaker fees from Genzyme-Sanofi, Novartis, GeNeuro, and Roche; and (3) research support from Siemens, GeNeuro, and Roche.

Correspondence to: Cristina Granziera, MD, PhD, Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Petersgraben 4, 4031 Basel, Switzerland. E-mail: [email protected].

Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.investigativeradiology.com).

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