Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment

Baghban R, Roshangar L, Jahanban-Esfahlan R, Seidi K, Ebrahimi-Kalan A, Jaymand M, et al. Tumor microenvironment complexity and therapeutic implications at a glance. Cell Commun Signal. 2020;18(1):59.

PubMed  PubMed Central  Article  Google Scholar 

Sneeggen M, Guadagno NA, Progida C. Intracellular transport in cancer metabolic reprogramming. Front Cell Dev Biol. 2020;8:597608.

PubMed  PubMed Central  Article  Google Scholar 

Zhang J, Zhang X, Liu G, Chang D, Liang X, Zhu X, et al. Intracellular trafficking network of protein nanocapsules: endocytosis, exocytosis and autophagy. Theranostics. 2016;6(12):2099–113.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Jin H, Tang Y, Yang L, Peng X, Li B, Fan Q, et al. Rab GTPases: central coordinators of membrane trafficking in cancer. Front Cell Dev Biol. 2021;9:648384.

PubMed  PubMed Central  Article  Google Scholar 

Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol. 2009;10(8):513–25.

CAS  PubMed  Article  Google Scholar 

Kuo IY, Yang YE, Yang PS, Tsai YJ, Tzeng HT, Cheng HC, et al. Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment. Theranostics. 2021;11(14):7029–44.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mayorga LS, Cebrian I. Rab22a: a novel regulator of immune functions. Mol Immunol. 2019;113:87–92.

CAS  PubMed  Article  Google Scholar 

Tzeng HT, Su CC, Chang CP, Lai WW, Su WC, Wang YC. Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype. Int J Cancer. 2018;143(7):1753–63.

CAS  PubMed  Article  Google Scholar 

Ramadass M, Catz SD. Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation. Immunol Rev. 2016;273(1):249–65.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213–28.

PubMed  Article  CAS  Google Scholar 

Xie F, Zhou X, Fang M, Li H, Su P, Tu Y, et al. Extracellular vesicles in cancer immune microenvironment and cancer immunotherapy. Adv Sci (Weinh). 2019;6(24):1901779.

CAS  Article  Google Scholar 

Teng F, Fussenegger M. Shedding light on extracellular vesicle biogenesis and bioengineering. Adv Sci (Weinh). 2020;8(1):2003505.

Article  CAS  Google Scholar 

Urabe F, Kosaka N, Ito K, Kimura T, Egawa S, Ochiya T. Extracellular vesicles as biomarkers and therapeutic targets for cancer. Am J Physiol Cell Physiol. 2020;318(1):C29-39.

CAS  PubMed  Article  Google Scholar 

Mizushima N. A brief history of autophagy from cell biology to physiology and disease. Nat Cell Biol. 2018;20(5):521–7.

CAS  PubMed  Article  Google Scholar 

Padmanabhan S, Manjithaya R. Facets of autophagy based unconventional protein secretion-the road less traveled. Front Mol Biosci. 2020;7:586483.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shenoy GN, Bhatta M, Bankert RB. Tumor-associated exosomes: a potential therapeutic target for restoring anti-tumor T cell responses in human tumor microenvironments. Cells. 2021;10(11):3155.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Goud B, Liu S, Storrie B. Rab proteins as major determinants of the Golgi complex structure. Small GTPases. 2018;9(1–2):66–75.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lamber EP, Siedenburg AC, Barr FA. Rab regulation by GEFs and GAPs during membrane traffic. Curr Opin Cell Biol. 2019;59:34–9.

CAS  PubMed  Article  Google Scholar 

Cai H, Reinisch K, Ferro-Novick S. Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev Cell. 2007;12(5):671–82.

CAS  PubMed  Article  Google Scholar 

Grosshans BL, Ortiz D, Novick P. Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci USA. 2006;103(32):11821–7.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kiral FR, Kohrs FE, Jin EJ, Hiesinger PR. Rab GTPases and membrane trafficking in neurodegeneration. Curr Biol. 2018;28(8):R471–86.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tzeng HT, Wang YC. Rab-mediated vesicle trafficking in cancer. J Biomed Sci. 2016;23(1):70.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Hendrix A, De Wever O. Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment. Int J Mol Sci. 2013;14(5):9883–92.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Hendrix A, Maynard D, Pauwels P, Braems G, Denys H, Van den Broecke R, et al. Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst. 2010;102(12):866–80.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Nishioka S, Wu PH, Yakabe T, Giaccia AJ, Le QT, Aoyama H, et al. Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma. Neurooncol Adv. 2020;2(1):vdaa091.

PubMed  PubMed Central  Google Scholar 

Wang JS, Wang FB, Zhang QG, Shen ZZ, Shao ZM. Enhanced expression of Rab27A gene by breast cancer cells promoting invasiveness and the metastasis potential by secretion of insulin-like growth factor-II. Mol Cancer Res. 2008;6(3):372–82.

CAS  PubMed  Article  Google Scholar 

Tsai CH, Cheng HC, Wang YS, Lin P, Jen J, Kuo IY, et al. Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis. Nat Commun. 2014;5:4804.

CAS  PubMed  Article  Google Scholar 

Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, et al. Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis. Clin Cancer Res. 2017;23(9):2335–45.

CAS  PubMed  Article  Google Scholar 

Cho SH, Kuo IY, Lu PF, Tzeng HT, Lai WW, Su WC, et al. Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness. Cell Death Dis. 2018;9(9):868.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Tzeng HT, Li TH, Tang YA, Tsai CH, Frank Lu PJ, Lai WW, et al. Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37. Oncotarget. 2017;8(65):108556–70.

PubMed  PubMed Central  Article  Google Scholar 

Wang YS, Tzeng HT, Tsai CH, Cheng HC, Lai WW, Liu HS, et al. VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function. Cancer Lett. 2018;437:79–88.

CAS  PubMed  Article  Google Scholar 

Choi J, Sung JY, Lee S, Yoo J, Rongo C, Kim YN, et al. Rab8 and Rabin8-mediated tumor formation by hyperactivated EGFR signaling via FGFR signaling. Int J Mol Sci. 2020;21(20):7770.

CAS  PubMed Central  Article  Google Scholar 

Dozynkiewicz MA, Jamieson NB, Macpherson I, Grindlay J, van den Berghe PV, von Thun A, et al. Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell. 2012;22(1):131–45.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bravo-Cordero JJ, Marrero-Diaz R, Megias D, Genis L, Garcia-Grande A, Garcia MA, et al. MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J. 2007;26(6):1499–510.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, et al. RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs. EMBO Rep. 2016;17(7):1061–80.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Boudhraa Z, Carmona E, Provencher D, Mes-Masson AM. Ran GTPase: a key player in tumor progression and metastasis. Front Cell Dev Biol. 2020;8:345.

PubMed  PubMed Central  Article  Google Scholar 

Porther N, Barbieri MA. The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells. Small GTPases. 2015;6(3):135–44.

CAS 

留言 (0)

沒有登入
gif