Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes

Organization WH Global Report on Diabetes. France: WHO; 2016.

Abdul-Ghani MA, DeFronzo RA. Pathogenesis of insulin resistance in skeletal muscle. J Biomed Biotechnol. 2010;2010:476279.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009;9:311–26.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tai ES, Tan ML, Stevens RD, Low YL, Muehlbauer MJ, Goh DL, et al. Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. Diabetologia. 2010;53:757–67.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Krebs M, Krssak M, Bernroider E, Anderwald C, Brehm A, Meyerspeer M, et al. Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Diabetes. 2002;51:599–605.

CAS  PubMed  Article  Google Scholar 

Huffman KM, Shah SH, Stevens RD, Bain JR, Muehlbauer M, Slentz CA, et al. Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care. 2009;32:1678–83.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Perng W, Gillman MW, Fleisch AF, Michalek RD, Watkins SM, Isganaitis E, et al. Metabolomic profiles and childhood. Obes Obes. 2014;22:2570–8.

CAS  Google Scholar 

Palmer ND, Stevens RD, Antinozzi PA, Anderson A, Bergman RN, Wagenknecht LE, et al. Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab. 2015;100:E463–8.

CAS  PubMed  Article  Google Scholar 

Xu F, Tavintharan S, Sum CF, Woon K, Lim SC, Ong CN. Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics. J Clin Endocrinol Metab. 2013;98:E1060–5.

CAS  PubMed  Article  Google Scholar 

Shah SH, Crosslin DR, Haynes CS, Nelson S, Turer CB, Stevens RD, et al. Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss. Diabetologia. 2012;55:321–30.

CAS  PubMed  Article  Google Scholar 

Walford GA, Ma Y, Clish C, Florez JC, Wang TJ, Gerszten RE, et al. Metabolite profiles of diabetes incidence and intervention response in the diabetes prevention program. Diabetes 2016;65:1424–33.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wurtz P, Soininen P, Kangas AJ, Ronnemaa T, Lehtimaki T, Kahonen M, et al. Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults. Diabetes Care. 2013;36:648–55.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E. Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab. 2021;106:e1827–e36.

PubMed  Article  Google Scholar 

Nishimura J, Masaki T, Arakawa M, Seike M, Yoshimatsu H. Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARalpha and uncoupling protein in diet-induced obese mice. J Nutr. 2010;140:496–500.

CAS  PubMed  Article  Google Scholar 

Nie C, He T, Zhang W, Zhang G, Ma X. Branched chain amino acids: beyond nutrition metabolism. Int J Mol Sci. 2018;19:954.

PubMed Central  Article  CAS  Google Scholar 

Gancheva S, Jelenik T, Alvarez-Hernandez E, Roden M. Interorgan metabolic crosstalk in human insulin resistance. Physiol Rev. 2018;98:1371–415.

CAS  PubMed  Article  Google Scholar 

Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, et al. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011;17:448–53.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Floegel A, Stefan N, Yu Z, Muhlenbruch K, Drogan D, Joost HG, et al. Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes. 2013;62:639–48.

CAS  PubMed  PubMed Central  Article  Google Scholar 

McCormack SE, Shaham O, McCarthy MA, Deik AA, Wang TJ, Gerszten RE, et al. Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatr Obes. 2013;8:52–61.

CAS  PubMed  Article  Google Scholar 

Hamley S, Kloosterman D, Duthie T, Dalla Man C, Visentin R, Mason SA, et al. Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids. Diabetologia. 2019;62:2310–24.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Merino J, Leong A, Liu CT, Porneala B, Walford GA, von Grotthuss M, et al. Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose. Diabetologia. 2018;61:1315–24.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E, et al. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes. 2005;54:2674–84.

CAS  PubMed  Article  Google Scholar 

Lynch CJ, Adams SH. Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol. 2014;10:723–36.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Eagle H, Piez KA, Fleischman R, Oyama VI. Protein turnover in mammaliar cell cultures. J Biol Chem. 1959;234:592–7.

CAS  PubMed  Article  Google Scholar 

Lerin C, Goldfine AB, Boes T, Liu M, Kasif S, Dreyfuss JM, et al. Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism. Mol Metab. 2016;5:926–36.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Cheng S, Wiklund P, Autio R, Borra R, Ojanen X, Xu L, et al. Adipose tissue dysfunction and altered systemic amino acid metabolism are associated with non-alcoholic fatty liver disease. PLoS One. 2015;10:e0138889.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Lake AD, Novak P, Shipkova P, Aranibar N, Robertson DG, Reily MD, et al. Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease. Amino Acids. 2015;47:603–15.

CAS  PubMed  Article  Google Scholar 

Meek SE, Persson M, Ford GC, Nair KS. Differential regulation of amino acid exchange and protein dynamics across splanchnic and skeletal muscle beds by insulin in healthy human subjects. Diabetes. 1998;47:1824–35.

CAS  PubMed  Article  Google Scholar 

Flakoll PJ, Kulaylat M, Frexes-Steed M, Hourani H, Brown LL, Hill JO, et al. Amino acids augment insulin’s suppression of whole body proteolysis. Am J Physiol. 1989;257:E839–47.

CAS  PubMed  Google Scholar 

Fukagawa NK, Minaker KL, Rowe JW, Goodman MN, Matthews DE, Bier DM, et al. Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in postabsorptive men. J Clin Invest. 1985;76:2306–11.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Glass DJ. PI3 kinase regulation of skeletal muscle hypertrophy and atrophy. Curr Top Microbiol Immunol. 2010;346:267–78.

CAS  PubMed  Google Scholar 

Schiaffino S, Mammucari C. Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. Skelet Muscle. 2011;1:4.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Milan G, Romanello V, Pescatore F, Armani A, Paik JH, Frasson L, et al. Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun. 2015;6:6670.

CAS  PubMed  Article  Google Scholar 

Sanchez AM, Candau RB, Bernardi H. FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis. Cell Mol Life Sci. 2014;71:1657–71.

CAS  PubMed  Article  Google Scholar 

O’Neill BT, Bhardwaj G, Penniman CM, Krumpoch MT, Suarez Beltran PA, Klaus K, et al. FoxO transcription factors are critical regulators of diabetes-related muscle atrophy. Diabetes. 2019;68:556–70.

PubMed  Article  CAS  Google Scholar 

Abdulla H, Smith K, Atherton PJ, Idris I. Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis. Diabetologia. 2016;59:44–55.

CAS  PubMed  Article  Google Scholar 

Wang X, Hu Z, Hu J, Du J, Mitch WE. Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology. 2006;147:4160–8.

CAS  PubMed  Article 

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