Proper expression of developmental genes requires extensive epigenomic remodelling. Dissecting the role of epigenetic factors in the embryo, where intracellular and intercellular signals dynamically interplay to regulate gene expression, remains a major challenge. Cheng, Mittnenzweig et al. used temporal, single-cell gene expression and epigenomic analysis in early mouse embryos to investigate the cellular role of the major DNA demethylation machinery, ten-eleven translocation (TET) dioxygenases.

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