aDepartment of Biomedicine, Aarhus University, Aarhus, Denmark

bDepartment of Translational Medical Sciences, University of Campania ‘L. Vanvitelli’, Naples

cBiogem, Institute of Molecular Biology and Genetics, Ariano Irpino, Italy

Correspondence to Francesco Trepiccione, MD, PhD, Department of Translational Medical Sciences University of Campania ‘L.Vanvitelli’, Via Pansini n 5, 80131 Naples, Italy. Tel: +39 0815666600; fax: +39 0815666821; e-mail: [email protected]