Local and systemic effects of adrenomedullin after intestinal ischemia reperfusion

Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/60242

metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v60i08.51008Title: Local and systemic effects of adrenomedullin after intestinal ischemia reperfusionAuthors: Oyar, Eser Oz
Yildirim, Zuhal
Pampal, Arzu
Ilhan, Ayse Sebnem
Unlu, Nese LortlarKeywords: Inflammation;Intestinal ischemic reperfusion injury;Oxidative stressIssue Date: Aug-2022Publisher: NIScPR-CSIR,IndiaAbstract: Adrenomedullin (AM) is a peptide proven to increase cellular tolerance to hypoxia and oxidative stresss and contribute angiogenesis. Despite its known therapeutic effects on myocardial, renal or spinal ischemic reperfusion injuries, its local and systemic effects on intestinal ischemic reperfusion injury still remain unknown. This study aims to demonstrate the local and systemic effects of AM on Intestinal Ischemic Reperfusion Injury (I-IRI) demonstrated in rats. Thirty male rats were randomly allocated to five groups: Control, Adrenomedullin (AM), Intestinal Ischemic Reperfusion Injury (I-IRI), Adrenomedullin and Intestinal Ischemic Reperfusion Injury (AM+I-IRI), and Intestinal Ischemic Reperfusion Injury and Adrenomedullin (I-IRI+AM). Blood and tissue samples were obtained for biochemical and histopathological evaluation. The results were expressed as mean±SEM and, P Page(s): 580-586ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.60(08) [AUG 2022]

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