Dynamin prime

Endocytosis at synapses involves the formation of endocytic pits next to the active zone, which are then internalized in a process catalysed by the GTPase dynamin. However, it is unclear how dynamin, which takes tens of seconds to be recruited from the cytosol to the endocytic zone, can participate in ultrafast endocytosis, which occurs in as little as 50 ms. Here, Imoto et al. show that a splice variant of dynamin 1 (Dnm1; hereafter, Dyn1), dynamin 1xA (Dyn1xA), interacts with the regulatory protein syndapin 1 (also known as Pacsin1) to form condensates at the endocytotic zone, providing a local, high concentration of dynamin ready to participate in ultrafast endocytosis.

This is a preview of subscription content

留言 (0)

沒有登入
gif