Ali N, Mattsson K, Rissler J, Karlsson HM, Svensson CR, Gudmundsson A, et al. Analysis of nanoparticle-protein coronas formed in vitro between nanosized welding particles and nasal lavage proteins. Nanotoxicology. 2016;10(2):226–34.

CAS  PubMed  Article  Google Scholar 

Antonini JM. Health effects of welding. Crit Rev Toxicol. 2003;33(1):61–103.

CAS  PubMed  Article  Google Scholar 

Antonini JM, Lewis AB, Roberts JR, Whaley DA. Pulmonary effects of welding fumes: review of worker and experimental animal studies. Am J Ind Med. 2003;43(4):350–60.

CAS  PubMed  Article  Google Scholar 

Ibfelt E, Bonde JP, Hansen J. Exposure to metal welding fume particles and risk for cardiovascular disease in Denmark: a prospective cohort study. Occup Environ Med. 2010;67(11):772–7.

CAS  PubMed  Article  Google Scholar 

Zeidler-Erdely PC, Kashon ML, Battelli LA, Young SH, Erdely A, Roberts JR, et al. Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume. Part Fibre Toxicol. 2008;5:12.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Reisgen U, Geffers C, Willms K, Angerhausen M, Deckert K, Hof S, et al. Low-energy thermal joining with zinc and tin base solder for application in vehicle construction brazing, high temperature brazing and diffusion bonding. DVS-Berichte. 2013;293:272–7.

CAS  Google Scholar 

Blanc PD, Boushey HA, Wong H, Wintermeyer SF, Bernstein MS. Cytokines in metal fume fever. Am Rev Respir Dis. 1993;147(1):134–8.

CAS  PubMed  Article  Google Scholar 

Kuschner WG, D'Alessandro A, Wong H, Blanc PD. Early pulmonary cytokine responses to zinc oxide fume inhalation. Environ Res. 1997;75(1):7–11.

CAS  PubMed  Article  Google Scholar 

Baumann R, Brand P, Chaker A, Markert A, Rack I, Davatgarbenam S, et al. Human nasal mucosal C-reactive protein responses after inhalation of ultrafine welding fume particles: positive correlation to systemic C-reactive protein responses. Nanotoxicology. 2018;12(10):1130–47.

CAS  PubMed  Article  Google Scholar 

Baumann R, Joraslafsky S, Markert A, Rack I, Davatgarbenam S, Kossack V, et al. IL-6, a central acute-phase mediator, as an early biomarker for exposure to zinc-based metal fumes. Toxicology. 2016;373:63–73.

CAS  PubMed  Article  Google Scholar 

Baumann R, Gube M, Markert A, Davatgarbenam S, Kossack V, Gerhards B, et al. Systemic serum amyloid A as a biomarker for exposure to zinc and/or copper containing metal fumes. J Expo Sci Environ Epidemiol. 2018;28(1):84–91.

CAS  PubMed  Article  Google Scholar 

Markert A, Baumann R, Gerhards B, Gube M, Kossack V, Kraus T, et al. Single and combined exposure to zinc- and copper-containing welding fumes Lead to asymptomatic systemic inflammation. J Occup Environ Med. 2016;58(2):127–32.

CAS  PubMed  Article  Google Scholar 

Krabbe J, Beilmann V, Gerhards B, Markert A, Thomas K, Kraus T, et al. The effects of repeated exposure to zinc- and copper-containing welding fumes on healthy volunteers. J Occup Environ Med. 2019;61(1):8–15.

CAS  PubMed  Article  Google Scholar 

Aweimer A, Jettkant B, Monse C, Hagemeyer O, van Kampen V, Kendzia B, et al. Heart rate variability and cardiac repolarization after exposure to zinc oxide nanoparticles in healthy adults. J Occup Med Toxicol. 2020;15:4.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lanone S, Rogerieux F, Geys J, Dupont A, Maillot-Marechal E, Boczkowski J, et al. Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines. Part Fibre Toxicol. 2009;6:14.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Cho WS, Duffin R, Howie SE, Scotton CJ, Wallace WA, Macnee W, et al. Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Part Fibre Toxicol. 2011;8:27.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Dempsey JL, Cui JY. Long non-coding RNAs: a novel paradigm for toxicology. Toxicol Sci. 2017;155(1):3–21.

CAS  PubMed  Article  Google Scholar 

Zhang Y, Sun L, Xuan L, Pan Z, Li K, Liu S, et al. Reciprocal changes of circulating long non-coding RNAs ZFAS1 and CDR1AS predict acute myocardial infarction. Sci Rep. 2016;6:22384.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chen C, Shen H, Huang Q, Li Q. The circular RNA CDR1as regulates the proliferation and apoptosis of human cardiomyocytes through the miR-135a/HMOX1 and miR-135b/HMOX1 axes. Genet Test Mol Biomarkers. 2020;24(9):537–48.

CAS  PubMed  Article  Google Scholar 

Yang Y, Cai Y, Wu G, Chen X, Liu Y, Wang X, et al. Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease. Clin Sci (Lond). 2015;129(8):675–85.

CAS  Article  Google Scholar 

Cai Y, Yang Y, Chen X, Wu G, Zhang X, Liu Y, et al. Circulating ‘lncRNA OTTHUMT00000387022’ from monocytes as a novel biomarker for coronary artery disease. Cardiovasc Res. 2016;112(3):714–24.

CAS  PubMed  Article  Google Scholar 

Lin YZ, Wu YP, Ke ZB, Cai H, Chen DN, Chen SH, et al. Bioinformatics analysis of the expression of key long intergenic non-protein coding RNA genes in bladder cancer. Med Sci Monit. 2020;26:e920504.

CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Wang X, Yan X, Cheng X, He X, Zheng W. LncRNA MALAT1 regulates sepsis-induced cardiac inflammation and dysfunction via interaction with miR-125b and p38 MAPK/NFkappaB. Int Immunopharmacol. 2018;55:69–76.

CAS  PubMed  Article  Google Scholar 

Tani H, Okuda S, Nakamura K, Aoki M, Umemura T. Short-lived long non-coding RNAs as surrogate indicators for chemical exposure and LINC00152 and MALAT1 modulate their neighboring genes. PLoS One. 2017;12(7):e0181628.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Lee JE, Cho SG, Ko SG, Ahrmad SA, Puga A, Kim K. Regulation of a long noncoding RNA MALAT1 by aryl hydrocarbon receptor in pancreatic cancer cells and tissues. Biochem Biophys Res Commun. 2020;532(4):563–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hartmann L, Bauer M, Bertram J, Gube M, Lenz K, Reisgen U, et al. Assessment of the biological effects of welding fumes emitted from metal inert gas welding processes of aluminium and zinc-plated materials in humans. Int J Hyg Environ Health. 2014;217(2–3):160–8.

CAS  PubMed  Article  Google Scholar 

Dewald E, Gube M, Baumann R, Bertram J, Kossack V, Lenz K, et al. Assessment of the biological effects of welding fumes emitted from metal active gas and manual metal arc welding in humans. J Occup Environ Med. 2015;57(8):845–50.

CAS  PubMed  Article  Google Scholar 

Brand P, Havlicek P, Steiners M, Holzinger K, Reisgen U, Kraus T, et al. Exposure of healthy subjects with emissions from a gas metal arc welding process: part 1--exposure technique and external exposure. Int Arch Occup Environ Health. 2013;86(1):25–30.

CAS  PubMed  Article  Google Scholar 

Li HM, Ma XL, Li HG. Intriguing circles: conflicts and controversies in circular RNA research. Wiley Interdiscip Rev RNA. 2019;10(5):e1538.

PubMed  Article  Google Scholar 

Cai W, Zhang Y, Su Z. ciRS-7 targeting miR-135a-5p promotes neuropathic pain in CCI rats via inflammation and autophagy. Gene. 2020;736:144386.

CAS  PubMed  Article  Google Scholar 

Huang Q, Chi Y, Deng J, Liu Y, Lu Y, Chen J, et al. Fine particulate matter 2.5 exerted its toxicological effect by regulating a new layer, long non-coding RNA. Sci Rep. 2017;7(1):9392.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Kong YG, Cui M, Chen SM, Xu Y, Xu Y, Tao ZZ. LncRNA-LINC00460 facilitates nasopharyngeal carcinoma tumorigenesis through sponging miR-149-5p to up-regulate IL6. Gene. 2018;639:77–84.

CAS  PubMed  Article  Google Scholar 

Zhang DD, Wang WT, Xiong J, Xie XM, Cui SS, Zhao ZG, et al. Long noncoding RNA LINC00305 promotes inflammation by activating the AHRR-NF-kappaB pathway in human monocytes. Sci Rep. 2017;7:46204.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Conover WJ. Practical nonparametric statistics. 3rd ed. Hoboken: John Wiley and Sons - Scientific Publishers; 1999. p. 584.

Google Scholar 

Cronholm P, Midander K, Karlsson HL, Elihn K, Wallinder IO, Moller L. Effect of sonication and serum proteins on copper release from copper nanoparticles and the toxicity towards lung epithelial cells. Nanotoxicology. 2011;5(2):269–81.

CAS  PubMed  Article  Google Scholar 

Midander K, Cronholm P, Karlsson HL, Elihn K, Moller L, Leygraf C, et al. Surface characteristics, copper release, and toxicity of nano- and micrometer-sized copper and copper(II) oxide particles: a cross-disciplinary study. Small. 2009;5(3):389–99.

CAS  PubMed  Article  Google Scholar 

Karlsson HL, Cronholm P, Hedberg Y, Tornberg M, De Battice L, Svedhem S, et al. Cell membrane damage and protein interaction induced by copper containing nanoparticles--importance of the metal release process. Toxicology. 2013;313(1):59–69.

CAS