Human colonic catabolism of dietary flavan-3-ol bioactives

Elsevier

Available online 2 August 2022, 101107

Molecular Aspects of MedicineAbstract

Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented.

Keywords

Flavan-3-ols

Colonic catabolic and phase II metabolism

[2–14C](−)-Epicatechin

Procyanidins

Theaflavins

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