Anthropogenic activity has created unique environmental drivers, which may interact to produce unexpected effects. My aim was to conduct a systematic review of the interactive effects of anthropogenic drivers on endocrine responses in non-human animals. The interaction between temperature and light can disrupt reproduction and growth by impacting gonadotropins, thyroid hormones, melatonin, and growth hormone. Temperature and endocrine disrupting compounds (EDCs) interact to modify reproduction with differential effects across generations. The combined effects of light and EDCs can be anxiogenic, so that light-at-night could increase anxiety in wildlife. Light and noise increase glucocorticoid release by themselves, and together can modify interactions between individuals and their environment. The literature detailing interactions between drivers is relatively sparse and there is a need to extend research to a broader range of taxa and interactions. I suggest that incorporating endocrine responses into Adverse Outcome Pathways would be beneficial to improve predictions of environmental effects.