Lansang CM, Umpierrez GE. Inpatient hyperglycemia management: a practical review for primary medical and surgical teams. Cleve Clin J Med. 2016;83:S34–43.

PubMed  Article  Google Scholar 

Ramos M, Khalpey Z, Lipsitz S, Steinberg J, Panizales MT, Zinner M, Rogers SO. Relationship of perioperative hyperlgycemia and postoperative infections in patients who undergo general and vascular surgery. Ann Surg. 2008;248:585–91.

PubMed  Article  Google Scholar 

Moghissi ES, Korytkowski MT, DiNardo M, Einhorn D, Hellman R, Hirsch IB, Inzucchi SE, Ismail-Beigi F, Kirkman MS, Umpierrez GE. American association of clinical endocrinologist and American diabetes association consensus statement on inpatient glycemic control. Diabetes Care. 2009;32:1119–31.

PubMed  PubMed Central  Article  Google Scholar 

American Diabetes Association. Diabetes care in the hospital: standards of medical care in diabetes - 2021. Diabetes Care. 2021;44:S211–20.

Article  Google Scholar 

Centers for disease control and prevention. National Diabetes Statistics Report, 2020. Atlanta, GA: Centers for Disease Control and Prevention, U.S. Dept of Health and Human Services; 2020.

Kulasa K, Juang P. How low can you go? Reducing rate of hypoglycemia in the non-critical care hospital setting. Curr Diab Rep. 2017;17:74.

PubMed  Article  Google Scholar 

Wei NJ, Wexler DJ. Basal-bolus insulin protocols enter the computer age. Curr Diab Rep. 2013;12:119–26.

Article  Google Scholar 

Ilcewicz HN, Hennessey EK, Smith CB. Evaluation of the impact of an inpatient hyperglycemia protocol on glycemic control. J Pharm Pharm Sci. 2019;22:1–130.

Article  Google Scholar 

Forrest GN, Van Schooneveld TC, Kullar R, Schulz LT, Doung P, Postelnick M. Use of electronic health records and clinical decision support systems for antimicrobial stewardship. Clin Infect Dis. 2104;49:S122–33.

Google Scholar 

McGreevey JD. Order sets in electronic health records. Chest. 2013;143:228–35.

PubMed  Article  Google Scholar 

Middleton B, Sitting DF, Wright A. Clinical decision support: a 25 year retrospective and 25 year vision. Yearb Med Inform. 2016;25:S103–16.

Article  Google Scholar 

Schnipper JL, Laing CL, Ndumele CD, Pendergrass ML. Effects of computerized order set on the inpatient management of hyperglycemia: a cluster-randomized control trial. Endocr Pract. 2010;16:209–18.

PubMed  Article  Google Scholar 

ISMP’s guidelines for standard order sets; 2010: Available from [ismp-hosp-temp-MASTER.qxd].

Thabit H, Hovorka R. Bridging technology and clinical practice: innovating inpatient hyperglycaemia management in non-critical care settings. Diabetic Med. 2017;35:460–71.

Article  Google Scholar 

Rushakoff RJ, Rushakoff JA, Kornberg Z, Windham MacMaster H, Shah AD. Remote monitoring and consultation of inpatient populations with diabetes. Curr Diab Rep 2017;17.

Maynard G, Lee J, Phillips G, Fink E, Renvall M. Improved inpatient use of basal insulin, reduced hypoglycemia, and improved glycemic control: effect of structured subcutaneous inulin order and an insulin management algorithm. J Hosp Med. 2009;4:3–15.

PubMed  Article  Google Scholar 

Donsa K, Beck P, Höll B, Mader JK, Lukas S, Plank J, Neubauer KM, Baumgartner C, Pieber TR. Impact of errors in paper-based and computerized diabetes management with decision support for hospitalized patients with type 2 diabetes. A post-hoc analysis of a before and after study. Int J Med Inform. 2016;90:58–67.

PubMed  Article  Google Scholar 

Umpierrez GE, Reyes D, Smiley D, Hermayer K, Khan A, Olson DE, Pasquel F, Jacobs S, Newton C, Peng L, Fonseca V. Hospital discharge algorithm based on admission HbA1c for the management of patients with type 2 diabetes. Diabetes Care. 2014;37:2934–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

The glycemic control implementation guide: improving glycemic control, preventing hypoglycemia and optimizing care of the inpatient with hyperglycemia and diabetes: Society of Hospital Medicine; 2015; second: Available from: https://www.hospitalmedicine.org/globalassets/clinical-topics/clinical-pdf/gcmi-guide-m4.pdf. Accessed 1 March 2022.

Wong B, Mamdani MM, Yu CH. Computerized insulin order sets and glycemic control in hospitalized patients. Am J Med. 2016;130:P366.E1-366.E6.

Article  Google Scholar 

Umpierrez GE, Smiley D, Zisman A, Prieto LM, Palacio A, Ceron M, Puig A, Mejia R. Randomized study of basal-bolus insulin therapy in the inpatient managmnt of patients with type 2 diaberes (RABBIT 2 Trial). Diabetes Care. 2007;30:2181–6.

CAS  PubMed  Article  Google Scholar 

Sinha Gregory N, Seley JJ, Ukena J, Shah S, Fred MR, Dargar SK, Mauer E, Kim RJ. Decreased rates of inpatient hypoglycemia following implementation of an automated tool in the electronic medical record for identifying root causes. J Diabetes Sci Technol. 2018;12(1):63–8.

PubMed  Article  Google Scholar 

Neinstein A, Windham MacMaster H, Sullivan MM. A detailed description of the implementation of inpatient insulin orders with a commercial electronic health record system. J Diabetes Sci Technol. 2014;8:641–51.

PubMed  PubMed Central  Article  Google Scholar 

Wexler DJ, Beauharnais CC, Regan S, Nathan DM, Cagliero E, Larkin ME. Impact of inpatient diabetes management, education, and improved discharge transition on glycemic control 12 months after discharge. Diabetes Res Clin Pr. 2012;98:249–56.

Article  Google Scholar 

Healy SJ, Black D, Harris C, Lorenz A, Dugan KM. Inpatient diabetes education is associated with less frequent hospital readmission among patients with poor glycemic control. Diabetes Care. 2013;36:2960–7.

PubMed  PubMed Central  Article  Google Scholar 

Bowen ME, Rumana U, Killgore EA, Gong Y. A user-centered glucose-insulin data display for the inpatient setting. Stud Health Technol Inform. 2017;245:684–8.

PubMed  PubMed Central  Google Scholar 

Howe JL, Adams KT, Hettinger AZ, Ratwani RM. Electronic health record usability issues and potential contribution to patient harm. JAMA. 2018;319(12):1276–2127.

PubMed  PubMed Central  Article  Google Scholar 

Rushakoff RJ, Sullivan MM, MacMaster HW, Shah AD, Rajkomar A, Glidden DV, Kohn MA. Association between a virtual glucose management service and glycemic control in hospitalized adult patients: an observational study. Ann Intern Med. 2017;166(9):621–7.

PubMed  Article  Google Scholar 

Pichardo-Lowden A, Umpierrez G, Lehman EB, Bolton MD, DeFlitch CJ, Chinchilli VM, Haidet PM. Clinical decision support to improve management of diabetes and dysglycemia in the hospital: a path to optimizing practice and outcomes. BMJ Open Diabetes Res Care. 2021;9(1):e001557.

PubMed  PubMed Central  Article  Google Scholar 

Kilpatrick CR, Elliott MB, Pratt E, Schafers SJ, Blackburn MC, Heard K, McGill JB, Thoelke M, Tobin GS. Prevention of inpatient hypoglycemia with a real-time informatics alert. J Hosp Med. 2014;9(10):621–6.

PubMed  Article  Google Scholar 

Kao SL, Chen Y, Ning Y, Tan M, Salloway M, Khoo EYH, Tai ES, Tan CS. Evaluating the effectiveness of a multi-faceted inpatient diabetes management program among hospitalised patients with diabetes mellitus. Clin Diabetes Endocrinol. 2020;6(1):21.

PubMed  PubMed Central  Article  Google Scholar 

Maynard G, Kulasa K, Ramos P, Childers D, Clay B, Sebasky M, Fink E, Field A, Renvall M, Juang PS, Choe C, Pearson D, Serences B, Lohnes S. Impact of a hypoglycemia reduction bundle and a systems approach to inpatient glycemic management. Endocr Pract. 2015;21(4):355–67.

PubMed  Article  Google Scholar 

Maynard GA, Childers D, Holdych J, Kendall H, Hoag T, Harrison K. Improving glycemic control safely in non-critical care patients: a collaborative systems approach in nine hospitals. Jt Comm J Qual Patient Saf. 2017;43(4):179–88.

PubMed  Google Scholar 

Sheen YJ, Huang CC, Huang SC, Huang MD, Lin CH, Lee IT, Lin SY, Sheu WH. Implementation of an electronic dashboard with a remote management system to improve glycemic management among hospitalized adults. Endocr Pract. 2020;26(2):179–91.

PubMed  Article  Google Scholar 

Mathioudakis NN, Everett E, Routh S, Pronovost PJ, Yeh HC, Golden SH, Saria S. Development and validation of a prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults. BMJ Open Diabetes Res Care. 2018;6(1):e000499.

PubMed  PubMed Central  Article  Google Scholar 

Elliott MB, Schafers SJ, McGill JB, Tobin GS. Prediction and prevention of treatment-related inpatient hypoglycemia. J Diabetes Sci Technol. 2012;6(2):302–9.

PubMed  PubMed Central  Article  Google Scholar 

Milligan PE, Bocox MC, Pratt E, Hoehner CM, Krettek JE, Dunagan WC. Multifaceted approach to reducing occurrence of severe hypoglycemia in a large healthcare system. Am J Health Syst Pharm. 2015;72(19):1631–41.

PubMed  Article  Google Scholar 

Umpierrez GE, Hellman R, Korytkowski MT, Kosiborod M, Maynard GA, Montori VM, Seley JJ, Van den Berghe G, Endocrine Society. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(1):16–38.

CAS  PubMed  Article  Google Scholar 

Sinha Gregory N, Seley JJ, Gerber LM, Tang C, Brillon D. Decreased rates of hypoglycemia following implementation of a comprehensive computerized insulin order set and titration algorithm in the inpatient setting. Hosp Pract (1995). 2016;44(5):260–5.

Article  Google Scholar 

Umpierrez G, Korytkowski M. Diabetic emergencies – ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia. Nat Rev Endocrinol. 2016;12:222–32.

CAS  PubMed  Article  Google Scholar 

Laliberte B, Yeung SYA, Gonzalez JP. Impact of diabetic ketoacidosis management in the medical intensive care unit after order set implementation. Int J Pharm Pract. 2017;25:238–43.

PubMed  Article  Google Scholar 

Ekanayake PS, Juang PS, Kulasa K. Review of intravenous and subcutaneous electronic glucose management systems for inpatient glycemic control. Curr Diab Rep. 2020;20(12):68.

PubMed  Article  Google Scholar 

Ullal J, Aloi JA, Reyes-Umpierrez D, Pasquel FJ, McFarland R, Rabinovich M, et al. Comparison of computer-guided versus standard insulin infusion regimens in patients with diabetic ketoacidosis. J Diabetes Sci Technol. 2018;12(1):39–46.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kulasa K, Serences B, Nies M, El-Kareh R, Kurashige K, Box K. Insulin infusion computer calculator programmed directly into electronic health record medication administration record. J Diabetes Sci Tech. 2021;15(2):214–21.

Article  Google Scholar