Brooks GA. Lactate: glycolytic end product and oxidative substrate during sustained exercise in mammals—the ‘lactate shuttle.’ In: Gilles R, editor. Circulation, Respiration, and Metabolism: Current Comparative Approaches. Berlin: Springer-Verlag Press; 1985. p. 208–18.
Brooks GA. Mammalian fuel utilization during sustained exercise. Comp Biochem Physiol. 1998;120:89–107. https://doi.org/10.1016/S0305-0491(98)00025-X.
Todd JJ. Lactate: valuable for physical performance and maintenance of brain function during exercise. Biosci Horizons. 2014;7:hzu001–hzu001. https://doi.org/10.1093/biohorizons/hzu001.
Harris RA, Lone A, Lim H, Martinez F, Frame AK, Scholl TJ, et al. Aerobic glycolysis is required for spatial memory acquisition but not memory retrieval in mice. eNeuro. 2018. https://doi.org/10.1523/ENEURO.0389-18.2019.
Belanger M, Allaman I, Magistretti PJ. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab. 2011;14:724–38. https://doi.org/10.1016/j.cmet.2011.08.016.
Article PubMed CAS Google Scholar
Porras OH, Loaiza A, Barros LF. Glutamate mediates acute glucose transport inhibition in hippocampal neurons. J Neurosci. 2004;24:9669–73. https://doi.org/10.1523/JNEUROSCI.1882-04.2004.
Article PubMed PubMed Central CAS Google Scholar
Barros LF, Courjaret R, Jakoby P, Loaiza A, Lohr C, Deitmer JW. Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: a multiphoton study of cerebellar slices. Glia. 2009;57:962–70. https://doi.org/10.1002/glia.20820.
Article PubMed CAS Google Scholar
Riske L, Thomas RK, Baker GB, Dursun SM. Lactate in the brain: an update on its relevance to brain energy, neurons, glia and panic disorder. Ther Adv Psychopharmacol. 2017;7:85–9. https://doi.org/10.1177/2045125316675579.
Article PubMed CAS Google Scholar
van Hall G. Lactate kinetics in human tissues at rest and during exercise. Acta Physiol. 2010;199:499–508. https://doi.org/10.1111/j.1748-1716.2010.02122.x.
Bouzier-Sore AK, Voisin P, Bouchaud V, Bezancon E, Franconi JM, Pellerin L. Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study. Eur J Neurosci. 2006;24:1687–94. https://doi.org/10.1111/j.1460-9568.2006.05056.x.
Pierre K, Pellerin L. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem. 2005;94:1–14. https://doi.org/10.1111/j.1471-4159.2005.03168.x.
Article PubMed CAS Google Scholar
Delgado MG, Oliva C, López E, Ibacache A, Galaz A, Delgado R, et al. Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress. Rep. 2018;8:1186. https://doi.org/10.1038/s41598-018-19595-5.
Henneberger C, Petzold GC. Diversity of synaptic astrocyte–neuron signaling. e-Neuroforum. 2015;6:79–83. https://doi.org/10.1007/s13295-015-0011-1.
Finsterwald C, Magistretti PJ, Lengacher S. Astrocytes: new targets for the treatment of neurodegenerative diseases. Curr Pharm Des. 2015;21:3570–81. https://doi.org/10.2174/1381612821666150710144502.
Article PubMed CAS Google Scholar
Magistretti PJ, Allaman I. A cellular perspective on brain energy metabolism and functional imaging. Neuron. 2015;86:883–901. https://doi.org/10.1016/j.neuron.2015.03.035.
Article PubMed CAS Google Scholar
Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A. 1994;91:10625–9. https://doi.org/10.1073/pnas.91.22.10625.
Article PubMed PubMed Central CAS Google Scholar
Magistretti PJ. Neuron-glia metabolic coupling and plasticity. Exp Physiol. 2011;96:407–10. https://doi.org/10.1113/expphysiol.2010.053157.
Article PubMed CAS Google Scholar
Nortley R, Attwell D. Control of brain energy supply by astrocytes. Curr Opin Neurobiol. 2017;47:80–5. https://doi.org/10.1016/j.conb.2017.09.012.
Article PubMed CAS Google Scholar
Pellerin L, Magistretti PJ. Sweet sixteen for ANLS. J Cereb Blood Flow Metab. 2012;32:1152–66. https://doi.org/10.1038/jcbfm.2011.149.
Article PubMed CAS Google Scholar
Cataldo AM, Broadwell RD. Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. II. Choroid plexus and ependymal epithelia, endothelia and pericytes. J Neurocytol. 1986;15:511–24. https://doi.org/10.1007/BF01611733.
Article PubMed CAS Google Scholar
Pfeiffer-Guglielmi B, Fleckenstein B, Jung G, Hamprecht B. Immunocytochemical localization of glycogen phosphorylase isozymes in rat nervous tissues by using isozyme-specific antibodies. J Neurochem. 2003;85:73–81. https://doi.org/10.1046/j.1471-4159.2003.01644.x.
Article PubMed CAS Google Scholar
Magistretti PJ, Allaman I. Glycogen: a Trojan horse for neurons. Nat Neurosci. 2007;10:1341–2. https://doi.org/10.1038/nn1107-1341.
Article PubMed CAS Google Scholar
Vilchez D, Ros S, Cifuentes D, Pujadas L, Valles J, Garcia-Fojeda B, et al. Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy. Nat Neurosci. 2007;10:1407–13. https://doi.org/10.1038/nn1998.
Article PubMed CAS Google Scholar
Duran J, Tevy MF, Garcia-Rocha M, Calbo J, Milan M, Guinovart JJ. Deleterious effects of neuronal accumulation of glycogen in flies and mice. EMBO Mol Med. 2012;4:719–29. https://doi.org/10.1002/emmm.201200241.
Article PubMed PubMed Central CAS Google Scholar
Cali C, Baghabra J, Boges DJ, Holst GR, Kreshuk A, Hamprecht FA, et al. Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues. J Comp Neurol. 2016;524:23–38. https://doi.org/10.1002/cne.23852.
Article PubMed CAS Google Scholar
Mohammed H, Al-Awami AK, Beyer J, Cali C, Magistretti P, Pfister H, et al. Abstractocyte: a visual tool for exploring nanoscale astroglial cells. IEEE Trans Vis Comput Graph. 2018;24:853–61. https://doi.org/10.1109/TVCG.2017.2744278.
Felmlee MA, Jones RS, Rodriguez-Cruz V, Follman KE, Morris ME. Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease. Pharmacol Rev. 2020;72:466–85. https://doi.org/10.1124/pr.119.018762.
Article PubMed PubMed Central CAS Google Scholar
Pellerin L. Food for thought: the importance of glucose and other energy substrates for sustaining brain function under varying levels of activity. Diab Metab. 2010;36(Suppl 3):S59-63. https://doi.org/10.1016/S1262-3636(10)70469-9.
Halestrap AP, Wilson MC. The monocarboxylate transporter family–role and regulation. IUBMB Life. 2012;64:109–19. https://doi.org/10.1002/iub.572.
Article PubMed CAS Google Scholar
Halestrap AP. The SLC16 gene family—structure, role and regulation in health and disease. Mol Aspects Med. 2013;34:337–49. https://doi.org/10.1016/j.mam.2012.05.003.
Article PubMed CAS Google Scholar
Elizondo-Vega R, Garcia-Robles MA. Molecular characteristics, regulation, and function of monocarboxylate transporters. Adv Neurobiol. 2017;16:255–67. https://doi.org/10.1007/978-3-319-55769-4_12.
Chenal J, Pellerin L. Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway. J Neurochem. 2007;102:389–97. https://doi.org/10.1111/j.1471-4159.2007.04495.x.
Article PubMed CAS Google Scholar
Chenal J, Pierre K, Pellerin L. Insulin and IGF-1 enhance the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin pathway. Eur J Neurosci. 2008;27:53–65. https://doi.org/10.1111/j.1460-9568.2007.05981.x.
Robinet C, Pellerin L. Brain-derived neurotrophic factor enhances the expression of the monocarboxylate transporter 2 through translational activation in mouse cultured cortical neurons. J Cereb Blood Flow Metab. 2010;30:286–98. https://doi.org/10.1038/jcbfm.2009.208.
Article PubMed CAS Google Scholar
Pierre K, Chatton JY, Parent A, Repond C, Gardoni F, Luca Di, et al. Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process. Eur J Neurosci. 2009;29:1951–63. https://doi.org/10.1111/j.1460-9568.2009.06756.x.
Magistretti PJ, Allaman I. Lactate in the brain: from metabolic end-product to signalling molecule. Nat Rev Neurosci. 2018;19:235–49. https://doi.org/10.1038/nrn.2018.19.
Article PubMed CAS Google Scholar
Reed T, Perluigi M, Sultana R, Pierce WM, Klein JB, Turner DM, et al. Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer’s disease. Neurobiol Dis. 2008;30:107–20. https://doi.org/10.1016/j.nbd.2007.12.007.
留言 (0)