Ferlay JEM, Lam F, Colombet M, Mery L, Piñeros M, Znaor A, et al. Global cancer observatory: cancer today. Lyon, France: International Agency for Research on Cancer; 2020.
Mariotto AB, Enewold L, Zhao J, Zeruto CA, Yabroff KR. Medical care costs associated with cancer survivorship in the United States. Cancer Epidemiol Biomark Prev. 2020;29:1304–12.
Mariotto AB, Yabroff KR, Shao Y, Feuer EJ, Brown ML. Projections of the cost of cancer care in the United States: 2010–2020. J Natl Cancer Inst. 2011;103:117–28.
PubMed PubMed Central Article Google Scholar
Kazanets A, Shorstova T, Hilmi K, Marques M, Witcher M. Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential. Biochim Biophys Acta. 2016;1865:275–88.
Dammann R, Li C, Yoon JH, Chin PL, Bates S, Pfeifer GP. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet. 2000;25:315–9.
CAS PubMed Article Google Scholar
Kiehl S, Zimmermann T, Savai R, Pullamsetti SS, Seeger W, Bartkuhn M, et al. Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer. Sci Rep. 2017;7:3896.
PubMed PubMed Central Article CAS Google Scholar
Bogdanovic O, Veenstra GJ. DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma 2009;118:549–65.
CAS PubMed PubMed Central Article Google Scholar
Kuster MM, Schneider MA, Richter AM, Richtmann S, Winter H, Kriegsmann M, et al. Epigenetic inactivation of the tumor suppressor IRX1 occurs frequently in lung adenocarcinoma and its silencing is associated with impaired prognosis. Cancers. 2020;12:3528.
PubMed Central Article CAS Google Scholar
Richter AM, Woods ML, Kuster MM, Walesch SK, Braun T, Boettger T, et al. RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice. Oncogene 2020;39:3114–27.
CAS PubMed PubMed Central Article Google Scholar
Gaozza E, Baker SJ, Vora RK, Reddy EP. AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Oncogene 1997;15:3127–35.
CAS PubMed Article Google Scholar
Raghunath M, Patti R, Bannerman P, Lee CM, Baker S, Sutton LN, et al. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. Brain Res Mol Brain Res. 2000;77:151–62.
CAS PubMed Article Google Scholar
Takano T, Urushibara T, Yoshioka N, Saito T, Fukuda M, Tomomura M, et al. LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes. Mol Biol Cell. 2014;25:1755–68.
PubMed PubMed Central Article Google Scholar
Nishino H, Saito T, Wei R, Takano T, Tsutsumi K, Taniguchi M, et al. The LMTK1-TBC1D9B-Rab11A cascade regulates dendritic spine formation via endosome trafficking. J Neurosci. 2019;39:9491–502.
CAS PubMed PubMed Central Article Google Scholar
Sharma G, Tsutsumi K, Saito T, Asada A, Ando K, Tomomura M, et al. Kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons. Genes Cells. 2016;21:1080–94.
CAS PubMed Article Google Scholar
Ding LY, Hou YC, Kuo IY, Hsu TY, Tsai TC, Chang HW, et al. Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer. Clin Epigenetics. 2020;12:87.
CAS PubMed PubMed Central Article Google Scholar
Haag T, Herkt CE, Walesch SK, Richter AM, Dammann RH. The apoptosis associated tyrosine kinase gene is frequently hypermethylated in human cancer and is regulated by epigenetic mechanisms. Genes Cancer. 2014;5:365–74.
CAS PubMed PubMed Central Article Google Scholar
Ma S, Rubin BP. Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma. Lab Invest. 2014;94:430–8.
CAS PubMed Article Google Scholar
Zhu RX, Song CH, Yang JS, Yi QT, Li BJ, Liu SH. Downregulation of AATK mediates microRNA-558-induced resistance of A549 cells to radiotherapy. Mol Med Rep. 2016;14:2846–52.
CAS PubMed Article Google Scholar
Wang H, Brautigan DL. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. J Biol Chem. 2002;277:49605–12.
CAS PubMed Article Google Scholar
Wendler F, Purice TM, Simon T, Stebbing J, Giamas G. The LMTK-family of kinases: Emerging important players in cell physiology and pathogenesis. Biochimica et biophysica acta Mol basis Dis. 2021;1867:165372.
Johnson SA, Hunter T. Kinomics: methods for deciphering the kinome. Nat Methods. 2005;2:17–25.
CAS PubMed Article Google Scholar
Weiss A, Neubauer MC, Yerabolu D, Kojonazarov B, Schlueter BC, Neubert L, et al. Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension. Nat Commun. 2019;10:2204.
PubMed PubMed Central Article CAS Google Scholar
Xiong Z, Laird PW. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res. 1997;25:2532–4.
CAS PubMed PubMed Central Article Google Scholar
Wanzel M, Vischedyk JB, Gittler MP, Gremke N, Seiz JR, Hefter M, et al. CRISPR-Cas9-based target validation for p53-reactivating model compounds. Nat Chem Biol. 2016;12:22–8.
CAS PubMed Article Google Scholar
Steinmann K, Sandner A, Schagdarsurengin U, Dammann RH. Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinoma. Oncol Rep. 2009;22:1519–26.
Cox J, Neuhauser N, Michalski A, Scheltema RA, Olsen JV, Mann M. Andromeda: a peptide search engine integrated into the MaxQuant environment. J Proteome Res. 2011;10:1794–805.
CAS PubMed Article Google Scholar
Cox J, Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol. 2008;26:1367–72.
CAS PubMed Article Google Scholar
Kiweler M, Looso M, Graumann J. MARMoSET—extracting publication-ready mass spectrometry metadata from RAW files. Mol Cell Proteom. 2019;18:1700–2.
Kheirollahi V, Wasnick RM, Biasin V, Vazquez-Armendariz AI, Chu X, Moiseenko A, et al. Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis. Nat Commun. 2019;10:2987.
PubMed PubMed Central Article CAS Google Scholar
Alack K, Weiss A, Kruger K, Horet M, Schermuly R, Frech T, et al. Profiling of human lymphocytes reveals a specific network of protein kinases modulated by endurance training status. Sci Rep. 2020;10:888.
CAS PubMed PubMed Central Article Google Scholar
Yerabolu D, Weiss A, Kojonazarov B, Boehm M, Schlueter BC, Ruppert C, et al. Targeting Jak-Stat signaling in experimental pulmonary hypertension. Am J Respir Cell Mol Biol. 2021;64:100–14.
CAS PubMed Article Google Scholar
Molenaar JJ, Koster J, Zwijnenburg DA, van Sluis P, Valentijn LJ, van der Ploeg I, et al. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. Nature 2012;483:589–93.
CAS PubMed Article Google Scholar
Diez-Villanueva A, Mallona I, Peinado MA. Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer. Epigenetics Chromatin. 2015;8:22.
PubMed PubMed Central Article CAS Google Scholar
Nagy A, Lanczky A, Menyhart O, Gyorffy B. Author Correction: Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 2018;8:11515.
PubMed PubMed Central Article CAS Google Scholar
Nagy A, Lanczky A, Menyhart O, Gyorffy B. Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 2018;8:9227.
PubMed PubMed Central Article CAS Google Scholar
Modhukur V, Iljasenko T, Metsalu T, Lokk K, Laisk-Podar T, Vilo J. MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data. Epigenomics 2018;10:277–88.
CAS PubMed Article Google Scholar
Li Y, Ge D, Lu C. The SMART App: an interactive web application for comprehensive DNA methylation analysis and visualization. Epigenetics Chromatin. 2019;12:71.
CAS PubMed PubMed Central Article Google Scholar
Tomomura M, Hasegawa Y, Hashikawa T, Tomomura A, Yuzaki M, Furuichi T, et al. Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain. Brain Res Mol Brain Res. 2003;112:103–12.
留言 (0)