aGastroenterology Department, Hospital da Senhora da Oliveira, Guimarães

bLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga

cICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal

Received 4 January 2022 Accepted 28 May 2022

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Correspondence to Vítor Macedo Silva, MD, Gastroenterology Department, Hospital da Senhora da Oliveira, Guimarães, Portugal, Rua dos Cutileiros, Creixomil. 4835-044, Guimarães, Tel: +351 253 540 330; fax: +253 513 592