Vaishnavi A, Le AT, Doebele RC. TRKing down an old oncogene in a new era of targeted therapy. Cancer Discov. 2015;5:25–34.
CAS PubMed Article Google Scholar
Amatu A, Sartore-Bianchi A, Bencardino K, Pizzutilo EG, Tosi F, Siena S. Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer. Ann Oncol. 2019;30:viii5–15.
CAS PubMed PubMed Central Article Google Scholar
Lamballe F, Klein R, Barbacid M. TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell. 1991;66:967–79.
CAS PubMed Article Google Scholar
Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk protooncogene product: a signal transducing receptor for nerve growth factor. Science. 1991;252:554–8.
CAS PubMed Article Google Scholar
Kaplan DR, Martin-Zanca D, Parada LF. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature. 1991;350:158–60.
CAS PubMed Article Google Scholar
Barbacid MJ. The Trk family of neurotrophin receptors. Neurobiol. 1994;25:1386–403.
Malcangio M, Lessmann V. A common thread for pain and memory synapses? Brain-derived neurotrophic factor and TrkB receptors. Trends Pharmacol Sci. 2003;24:116–21.
CAS PubMed Article Google Scholar
Binder DK, Scharfman HE. Brain-derived neurotrophic factor. Growth Factors. 2004;22:123–31.
CAS PubMed PubMed Central Article Google Scholar
Bothwell M. NGF, BDNF, NT3, and NT4. Handb Exp Pharmacol. 2014;220:3–15.
CAS PubMed Article Google Scholar
Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006;361:1545–64.
CAS PubMed PubMed Central Article Google Scholar
Bertrand T. Crystal structures of neurotrophin receptors kinase domain. Vitam Horm. 2017;104:1–18.
Barbacid M, Lamballe F, Pulido D, Klein R. The Trk family of tyrosine protein kinase receptors. Biochim Biophys Acta. 1991;1072:115–27.
Huang EJ, Reichardt LF. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem. 2003;72:609–42.
CAS PubMed Article Google Scholar
Vaishnavi A, Capelletti M, Le AT, Kako S, Butaney M, Ercan D, et al. Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nat Med. 2013;19:1469–72.
CAS PubMed PubMed Central Article Google Scholar
Connor B, Dragunow M. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res Rev. 1998;27:1–39.
CAS PubMed Article Google Scholar
Zhang F, Kang Z, Li W, Xiao Z, Zhou X. Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer’s disease. J Clin Neurosci. 2012;19:946–9.
CAS PubMed Article Google Scholar
Reinhart V, Bove SE, Volfson D, Lewis DA, Kleiman RJ, Lanz TA. Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder. Neurobiol Dis. 2015;77:220–7.
CAS PubMed Article Google Scholar
Song J-H, Yu J-T, Tan L. Brain-derived neurotrophic factor in Alzheimer’s disease: risk, mechanisms, and therapy. Mol Neurobiol. 2015;52:1477–93.
CAS PubMed Article Google Scholar
Meldolesi J. Neurotrophin receptors in the pathogenesis, diagnosis and therapy of neurodegenerative diseases. Pharmacol Res. 2017;121:129–37.
CAS PubMed Article Google Scholar
Ricciuti B, Genova C, Crinò L, Libra M, Leonardi GC. Antitumor activity of larotrectinib in tumors harboring NTRK gene fusions: a short review on the current evidence. Onco Targets Ther. 2019;12:3171–9.
CAS PubMed PubMed Central Article Google Scholar
Rohrberg KS, Lassen U. Detecting and targeting NTRK fusions in cancer in the era of tumor agnostic oncology. Drugs. 2021;81:445–52.
CAS PubMed Article Google Scholar
Gatalica Z, Xiu J, Swensen J, Vranic S. Molecular characterization of cancers with NTRK gene fusions. Mod Pathol. 2019;32:147–53.
CAS PubMed Article Google Scholar
Koizumi H, Morita M, Mikami S, Shibayama E, Uchikoshi T. Immunohistochemical analysis of TrkA neurotrophin receptor expression in human non-neuronal carcinomas. Pathol Int. 1998;48:93–101.
CAS PubMed Article Google Scholar
Roviello G, D’Angelo A, Sciortino M, Mini E, Nobili S, De Logu F, et al. TRK fusion positive cancers: from first clinical data of a TRK inhibitor to future directions. Crit Rev Oncol Hematol. 2020;152:103011.
Stenzinger A, van Tilburg CM, Tabatabai G, Länger F, Graf N, Griesinger F, et al. Diagnosis and therapy of tumors with NTRK gene fusion. Pathologe. 2021;42:103–15.
Federman N, McDermott R. Larotrectinib, a highly selective tropomyosin receptor kinase (TRK) inhibitor for the treatment of TRK fusion cancer. Expert Rev Clin Pharmacol. 2019;12:931–9.
CAS PubMed Article Google Scholar
Liu D, Offin M, Harnicar S, Li BT, Drilon A. Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of NTRK, ROS1, and ALK fusion-positive solid tumors. Ther Clin Risk Manag. 2018;14:1247–52.
CAS PubMed PubMed Central Article Google Scholar
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW. TRK fusion cancers in children: a clinical review and recommendations for screening. J Clin Oncol. 2019;37:513–24.
CAS PubMed Article Google Scholar
Cocco E, Scaltriti M, Drilon A. NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol. 2018;15:731–47.
CAS PubMed PubMed Central Article Google Scholar
Hsiao SJ, Zehir A, Sireci AN, Aisner DL. Detection of tumor NTRK gene fusions to identify patients who may benefit from tyrosine kinase (TRK) inhibitor therapy. J Mol Diagn. 2019;21:553–71.
CAS PubMed PubMed Central Article Google Scholar
Kirchner M, Glade J, Lehmann U, Merkelbach-Bruse S, Hummel M, Lehmann A, et al. NTRK testing: first results of the QuiP-EQA scheme and a comprehensive map of NTRK fusion variants and their diagnostic coverage by targeted RNA-based NGS assays. Genes Chromosomes Cancer. 2020;59:445–53.
CAS PubMed Article Google Scholar
Marchiò C, Scaltriti M, Ladanyi M, Iafrate AJ, Bibeau F, Dietel M, et al. ESMO recommendations on the standard methods to detect NTRK fusions in daily practice and clinical research. Ann Oncol. 2019;30:1417–27.
Penault-Llorca F, Rudzinski ER, Sepulveda AR. Testing algorithm for identification of patients with TRK fusion cancer. J Clin Pathol. 2019;72:460–7.
CAS PubMed Article Google Scholar
Pfarr N, Kirchner M, Lehmann U, Leichsenring J, Merkelbach-Bruse S, Glade J, et al. Testing NTRK testing: wet-lab and in silico comparison of RNA-based targeted sequencing assays. Genes Chromosomes Cancer. 2020;59:178–88.
CAS PubMed Article Google Scholar
Solomon JP, Hechtman JF. Detection of NTRK fusions: merits and limitations of current diagnosticplatforms. Cancer Res. 2019;79:3163–8.
CAS PubMed PubMed Central Article Google Scholar
Solomon JP, Linkov I, Rosado A, Mullaney K, Rosen EY, Frosina D, et al. NTRK fusion detection acrossmultiple assays and 33,997 cases: diagnostic implications and pitfalls. Mod Pathol. 2020;33:38–46.
CAS PubMed Article Google Scholar
Schirrmacher R, Bernard-Gauthier V, Jaworski C, Wangler C, Wangler B, Bailey JJ. Toward imaging tropomyosin receptor kinase (Trk) with positron emission tomography. In: Dierckx RAJO, Otte A, deVries EFJ, van Waarde A, editors. PET and SPECT of neurobiological systems. Switzerland: Springer Nature; 2021. p. 1041–59.
Bernard-Gauthier V, Aliaga A, Boudjemeline M, Hopewell R, Kostikov A, Rosa-Neto P, et al. Syntheses and evaluation of Carbon-11- and Fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-Aza-2-oxindole scaffold as Trk PET imaging agents. ACS Chem Neurosci. 2015;6:260–76.
CAS PubMed Article Google Scholar
Bernard-Gauthier V, Schirrmacher R. 5-(4-((4-[18F]fluorobenzyl)oxy)-3-methoxy-benzyl)pyrimidine-2,4-diamine: a selective dual inhibitor for potential PET imaging of Trk/CSF-1R. Bioorg Med Chem Lett. 2014;24:4784–90.
留言 (0)