aDepartment of Clinical Cardiology

bPathology Unit, Division of Experimental Oncology

cDepartment of Cardiac Surgery

dDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milano

eDepartment of Cardiothoracic and Vascular Anesthesia and Intensive Care, AO SS Antonio e Biagio e Cesare Arrigo, Alessandria

fDepartment of Cardiology, Royal Brompton Hospital, London, United Kingdom

gDepartment of Cardiac Surgery, ASST degli Spedali Civili di Brescia

hDepartment of Biostatistics, University Vita/Salute San Raffaele, Milano, Italy

Correspondence to Gabriele Fragasso, MD, Department of Clinical Cardiology, Heart Failure Clinic, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy Tel: +39 0226437366; fax: +39 0226437358; e-mail: [email protected]

Received 25 October, 2021

Revised 12 April, 2022

Accepted 29 May, 2022