Persistent Pulmonary Hypertension of Newborn

By definition, PPHN is present when an infant has severe hypoxemia out of proportion to lung disease, a structurally normal heart, and right to left shunt (atrial or ductal). HRF and PPHN can develop in late preterm and term infants as a complication of various underlying clinical conditions that cause maladaptation of the pulmonary blood vessels. These include perinatal asphyxia, meconium aspiration syndrome (MAS), respiratory distress syndrome (RDS), pneumonia, sepsis, pulmonary hypoplasia,

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