Lutter, M. & Nestler, E. J. Homeostatic and hedonic signals interact in the regulation of food intake. J. Nutr. 139, 629–632 (2009).
CAS PubMed PubMed Central Article Google Scholar
Rossi, M. A. & Stuber, G. D. Overlapping brain circuits for homeostatic and hedonic feeding. Cell Metab. 27, 42–56 (2018).
CAS PubMed Article Google Scholar
Yudkin, J. Pure, White, and Deadly: How Sugar is Killing Us and What We Can Do to Stop It (Penguin, 2013).
de Araujo, I. E., Schatzker, M. & Small, D. M. Rethinking food reward. Annu. Rev. Psychol. 71, 24.1–24.26 (2020).
Zuker, C. S. Food for the brain. Cell 161, 9–11 (2015).
CAS PubMed Article Google Scholar
Sherrington, C. The Integrative Action of the Nervous System (CUP Archive, 1952).
Yarmolinsky, D. A., Zuker, C. S. & Ryba, N. J. P. Common sense about taste: from mammals to insects. Cell 139, 234–244 (2009).
CAS PubMed PubMed Central Article Google Scholar
Gutierrez, R., Fonseca, E. & Simon, S. A. The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity. Cell. Mol. Life Sci. 77, 3469–3502 (2020).
CAS PubMed Article Google Scholar
Smith, D. V. & Margolskee, R. F. Making sense of taste. Sci. Am. 284, 32–39 (2001).
CAS PubMed Article Google Scholar
Adolph, E. F. Urges to eat and drink in rats. Am. J. Physiol. Content 151, 110–125 (1947).
Richter, C. P. Behavioral regulators of carbohydrate homeostasis. Acta Neuroveg. 9, 247–259 (1954).
Miller, N. E. & Kessen, M. L. Reward effects of food via stomach fistula compared with those of food via mouth. J. Comp. Physiol. Psychol. 45, 555–564 (1952). These experiments were some of the first to suggest the idea that post-ingestive signalling could induce reward.
CAS PubMed Article Google Scholar
Holman, G. L. Intragastric reinforcement effect. J. Comp. Physiol. Psychol. 69, 432–441 (1969). This paper demonstrated that post-ingestive signals could condition a flavour preference.
CAS PubMed Article Google Scholar
Puerto, A., Deutsch, J. A., Molina, F. & Roll, P. L. Rapid discrimination of rewarding nutrient by the upper gastrointestinal tract. Science 192, 485–487 (1976).
CAS PubMed Article Google Scholar
Smith, G. P. Satiation: from gut to brain (Oxford University Press, 1998).
Woods, S. C. The control of food intake: behavioral versus molecular perspectives. Cell Metab. 9, 489–498 (2009).
CAS PubMed PubMed Central Article Google Scholar
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S. & Schwartz, M. W. Central nervous system control of food intake and body weight. Nature 443, 289–295 (2006).
CAS PubMed Article Google Scholar
Sclafani, A. Gut–brain nutrient signaling. Appetition vs. satiation. Appetite 71, 454–458 (2013).
PubMed Article CAS Google Scholar
Sclafani, A. & Ackroff, K. Operant licking for intragastric sugar infusions: differential reinforcing actions of glucose, sucrose and fructose in mice. Physiol. Behav. 153, 115–124 (2016).
CAS PubMed Article Google Scholar
Sclafani, A. & Glendinning, J. I. Sugar and fat conditioned flavor preferences in C57BL/6J and 129 mice: oral and postoral interactions. Am. J. Physiol. Integr. Comp. Physiol. 289, R712–R720 (2005).
Ferreira, J. G., Tellez, L. A., Ren, X., Yeckel, C. W. & de Araujo, I. E. Regulation of fat intake in the absence of flavour signalling. J. Physiol. 590, 953–972 (2012).
CAS PubMed PubMed Central Article Google Scholar
Sclafani, A., Touzani, K. & Ackroff, K. Intragastric fat self-administration is impaired in GPR40/120 double knockout mice. Physiol. Behav. 147, 141–148 (2015).
CAS PubMed PubMed Central Article Google Scholar
Zukerman, S., Ackroff, K. & Sclafani, A. Rapid post-oral stimulation of intake and flavor conditioning by glucose and fat in the mouse. Am. J. Physiol. Integr. Comp. Physiol. 301, R1635–R1647 (2011).
Sclafani, A. & Ackroff, K. Flavor preferences conditioned by intragastric glucose but not fructose or galactose in C57BL/6J mice. Physiol. Behav. 106, 457–461 (2012).
CAS PubMed PubMed Central Article Google Scholar
Zukerman, S., Ackroff, K. & Sclafani, A. Post-oral appetite stimulation by sugars and nonmetabolizable sugar analogs. Am. J. Physiol. Integr. Comp. Physiol. 305, R840–R853 (2013).
Sclafani, A., Zukerman, S. & Ackroff, K. Postoral glucose sensing, not caloric content, determines sugar reward in C57BL/6J mice. Chem. Senses 40, 245–258 (2015). This work is part of a larger collection of studies by Sclafani and Ackroff24to show that the identity of a particular nutrient is sensed in the intestine and used to determine reward.
CAS PubMed PubMed Central Article Google Scholar
Myers, K. P. Robust preference for a flavor paired with intragastric glucose acquired in a single trial. Appetite 48, 123–127 (2007).
Buchanan, K. L. et al. The preference for sugar over sweetener depends on a gut sensor cell. Nat. Neurosci. 25, 191–200 (2022). This paper demonstrates that sugar preference arises from neuropod cells labelled by the CCK promoter in the proximal small intestine.
CAS PubMed PubMed Central Article Google Scholar
Nakagawa, Y. et al. Sweet taste receptor expressed in pancreatic β-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One 4, e5106 (2009).
PubMed PubMed Central Article CAS Google Scholar
Kyriazis, G. A., Soundarapandian, M. M. & Tyrberg, B. Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc. Natl Acad. Sci. USA 109, E524–E532 (2012).
CAS PubMed PubMed Central Article Google Scholar
Simon, B. R. et al. Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors. J. Biol. Chem. 288, 32475–32489 (2013).
CAS PubMed PubMed Central Article Google Scholar
Masubuchi, Y. et al. A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS One 8, e54500 (2013).
CAS PubMed PubMed Central Article Google Scholar
Ren, X., Zhou, L., Terwilliger, R., Newton, S. & de Araujo, I. E. Sweet taste signaling functions as a hypothalamic glucose sensor. Front. Integr. Neurosci. 3, 12 (2009).
PubMed PubMed Central Article CAS Google Scholar
Burdakov, D., Gerasimenko, O. & Verkhratsky, A. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J. Neurosci. 25, 2429–2433 (2005).
CAS PubMed PubMed Central Article Google Scholar
Yee, K. K., Sukumaran, S. K., Kotha, R., Gilbertson, T. A. & Margolskee, R. F. Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc. Natl Acad. Sci. USA 108, 5431–5436 (2011).
CAS PubMed PubMed Central Article Google Scholar
Suga, T. et al. SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels. Mol. Metab. 19, 1–12 (2019).
CAS PubMed Article Google Scholar
Koepsell, H. Glucose transporters in brain in health and disease. Pflügers Arch. J. Physiol. 472, 1299–1343 (2020).
Delaere, F. et al. The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing. Mol. Metab. 2, 47–53 (2013).
Dyer, J., Salmon, K. S. H., Zibrik, L. & Shirazi-Beechey, S. P. Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem. Soc. Trans. 33, 302–305 (2005).
CAS PubMed Article Google Scholar
Gorboulev, V. et al. Na+-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes 61, 187–196 (2012).
CAS PubMed Article Google Scholar
Reimann, F. & Gribble, F. M. Glucose-sensing in glucagon-like peptide-1-secreting cells. Diabetes 51, 2757–2763 (2002).
CAS PubMed Article Google Scholar
Max, M. et al. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat. Genet. 28, 58–63 (2001).
留言 (0)