Strome A, Kossatz S, Zanoni DK, Rajadhyaksha M, Patel S, Reiner T (2018) Current Practice and Emerging Molecular Imaging Technologies in Oral Cancer Screening. Mol Imaging 17:1536012118808644

Article  Google Scholar 

Ossovskaya V, Koo IC, Kaldjian EP, Alvares C, Sherman BM (2010) Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types. Genes Cancer 1(8):812–821

CAS  Article  Google Scholar 

Nosho K, Yamamoto H, Mikami M, Taniguchi H, Takahashi T, Adachi Y et al (2006) Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis. Eur J Cancer 42(14):2374–2381

CAS  Article  Google Scholar 

Staibano S, Pepe S, Lo Muzio L, Somma P, Mascolo M, Argenziano G et al (2005) Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region. Hum Pathol 36(7):724–731

CAS  Article  Google Scholar 

Michels J, Adam J, Goubar A, Obrist F, Damotte D, Robin A et al (2015) Negative prognostic value of high levels of intracellular poly(ADP-ribose) in non-small cell lung cancer. Ann Oncol 26(12):2470–2477

CAS  Article  Google Scholar 

Kossatz S, Pirovano G, De Souza Demetrio, Franca P, Strome AL, Sunny SP, Zanoni DK et al (2020) Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers. Nat Biomed Eng 4(3):272–85

CAS  Article  Google Scholar 

Kossatz S, Brand C, Gutiontov S, Liu JT, Lee NY, Gonen M et al (2016) Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Sci Rep 6:21371

CAS  Article  Google Scholar 

Boussios S, Karihtala P, Moschetta M, Karathanasi A, Sadauskaite A, Rassy E, et al (2019) Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review. Diagnostics (Basel) 9(3)

Moore K, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Banerjee S, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, Lowe ES, Bloomfield R, DiSilvestro P (2018) Maintenance olaparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med 379(26):2495–2505. https://doi.org/10.1056/NEJMoa1810858

Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, Redondo A et al (2016) Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. N Engl J Med 375(22):2154–2164

CAS  Article  Google Scholar 

Wilson RH, Evans TJ, Middleton MR, Molife LR, Spicer J, Dieras V et al (2017) A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours. Br J Cancer 116(7):884–892

CAS  Article  Google Scholar 

Reiner T, Lacy J, Keliher EJ, Yang KS, Ullal A, Kohler RH et al (2012) Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents. Neoplasia (New York, NY) 14(3):169–177

CAS  Article  Google Scholar 

Carney B, Kossatz S, Reiner T (2017) Molecular Imaging of PARP. J Nuclear Med 58(7):1025–1030

CAS  Article  Google Scholar 

Dubach JM, Vinegoni C, Mazitschek R, FumeneFeruglio P, Cameron LA, Weissleder R (2014) In vivo imaging of specific drug-target binding at subcellular resolution. Nat Commun 5:3946

CAS  Article  Google Scholar 

Dubach JM, Kim E, Yang K, Cuccarese M, Giedt RJ, Meimetis LG et al (2017) Quantitating drug-target engagement in single cells in vitro and in vivo. Nat Chem Biol 13(2):168–173

CAS  Article  Google Scholar 

Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T et al (2013) Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun 4:1504

Article  Google Scholar 

Carney B, Kossatz S, Lok BH, Schneeberger V, Gangangari KK, Pillarsetty NVK et al (2018) Target engagement imaging of PARP inhibitors in small-cell lung cancer. Nat Commun 9(1):176

Article  Google Scholar 

Kossatz S, Weber WA, Reiner T (2016) Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma. PLoS One 11(1):e0147752

Article  Google Scholar 

Chow JP, Man WY, Mao M, Chen H, Cheung F, Nicholls J et al (2013) PARP1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy. Mol Cancer Ther 12(11):2517–2528

CAS  Article  Google Scholar 

de Souza Demetrio, Franca P, Roberts S, Kossatz S, Guru N, Mason C, Zanoni DK et al (2020) Fluorine-18 labeled poly (ADP-ribose) polymerase1 inhibitor as a potential alternative to 2-deoxy-2-[(18)F]fluoro-d-glucose positron emission tomography in oral cancer imaging. Nuclear Med Biol 84–85:80–7

Google Scholar 

Demetrio de Souza Franca P, Guru N, Kostolansky AR, Mauguen A, Pirovano G, Kossatz S, et al (2020) Poly(ADP-ribose)polymerase1: A potential molecular marker to identify cancer during colposcopy procedures. J Nuclear Med

Pirovano G, Jannetti SA, Carter LM, Sadique A, Kossatz S, Guru N, Demétrio De Souza França P, Maeda M, Zeglis BM, Lewis JS, Humm JL, Reiner T (2020) Targeted brain tumor radiotherapy using an Auger emitter. Clin Cancer Res 26(12):2871–2881. https://doi.org/10.1158/1078-0432.CCR-19-2440

Edmonds CE, Makvandi M, Lieberman BP, Xu K, Zeng C, Li S et al (2016) [(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. Am J Nuclear Med Molec Imaging 6(1):94–101

CAS  Google Scholar 

Wilson TC, Xavier MA, Knight J, Verhoog S, Torres JB, Mosley M et al (2019) PET Imaging of PARP Expression Using (18)F-Olaparib. J Nuclear Med 60(4):504–510

CAS  Article  Google Scholar 

Carlucci G, Carney B, Brand C, Kossatz S, Irwin CP, Carlin SD et al (2015) Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma. Molec Imaging Biol: MIB 17(6):848–855

CAS  Article  Google Scholar 

Young RJ, Demétrio De Souza França P, Pirovano G, Piotrowski AF, Nicklin PJ, Riedl CC, et al (2020) Preclinical and first-in-human-brain-cancer applications of [18F]poly-(ADP-ribose) polymerase inhibitor PET/MR. Neuro-Oncol Adv

Schöder H, França PDS, Nakajima R, Burnazi E, Roberts S, Brand C, Grkovski M, Mauguen A, Dunphy MP, Ghossein RA, Lyashchenko SK, Lewis JS, O'Donoghue JA, Ganly I, Patel SG, Lee NY, Reiner T (2020) Safety and feasibility of PARP1/2 imaging with 18F-PARPi in patients with head and neck cancer. Clinical Cancer Res 26(13):3110–3116. https://doi.org/10.1158/1078-0432.CCR-19-3484

Michel LS, Dyroff S, Brooks FJ, Spayd KJ, Lim S, Engle JT, Phillips S, Tan B, Wang-Gillam A, Bognar C, Chu W, Zhou D, Mach RH, Laforest R, Chen DL (2017) PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies. Radiology 282(2):453–463. https://doi.org/10.1148/radiol.2016161929

Irwin CP, Portorreal Y, Brand C, Zhang Y, Desai P, Salinas B et al (2014) PARPi-FL–a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia (New York, NY) 16(5):432–440

CAS  Article  Google Scholar 

de Souza Demétrio, França P, Guru N, Roberts S, Kossatz S, Mason C, Abrahão M et al (2020) Fluorescence-guided resection of tumors in mouse models of oral cancer. Scientific Rep 10(1):11175

Article  Google Scholar 

Rangan SR (1972) A new human cell line (FaDu) from a hypopharyngeal carcinoma. Cancer 29(1):117–121

CAS  Article  Google Scholar 

Development & Approval Process | Drugs (2022) Available from: https://www.fda.gov/drugs/development-approval-process-drugs. Accessed 3 May 2022 

Mateo J, Lord CJ, Serra V, Tutt A, Balmaña J, Castroviejo-Bermejo M et al (2019) A decade of clinical development of PARP inhibitors in perspective. Ann Oncol 30(9):1437–1447

CAS  Article  Google Scholar 

Tang J, Salloum D, Carney B, Brand C, Kossatz S, Sadique A et al (2017) Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma. Proc Natl Acad Sci USA 114(36):E7441–E7449

CAS  PubMed  PubMed Central  Google Scholar 

Reiner T, Earley S, Turetsky A, Weissleder R (2010) Bioorthogonal small-molecule ligands for PARP1 imaging in living cells. Chembiochem : a European journal of chemical biology 11(17):2374–2377

CAS  Article  Google Scholar 

White JG, Amos WB, Fordham M (1987) An evaluation of confocal versus conventional imaging of biological structures by fluorescence light microscopy. J Cell Biol 105(1):41–48

CAS  Article  Google Scholar 

Ettinger A, Wittmann T (2014) Fluorescence live cell imaging. Methods Cell Biol 123:77–94

Article  Google Scholar 

The TH, Feltkamp TE (1970) Conjugation of fluorescein isothiocyanate to antibodies. I. Experiments on the conditions of conjugation. Immunology 18(6):865–73

CAS  PubMed  PubMed Central  Google Scholar 

Deka C, Lehnert BE, Lehnert NM, Jones GM, Sklar LA, Steinkamp JA (1996) Analysis of fluorescence lifetime and quenching of FITC-conjugated antibodies on cells by phase-sensitive flow cytometry. Cytometry 25(3):271–279

CAS  Article  Google Scholar 

Lu G, Rosenthal EL (2020) Translating a fluorescent DNA-repair inhibitor. Nature biomedical engineering 4(3):247–249

CAS  Article  Google Scholar 

Riggs JL, Seiwald RJ, Burckhalter JH, Downs CM, Metcalf TG (1958) Isothiocyanate compounds as fluorescent labeling agents for immune serum. Am J Pathol 34(6):1081–1097

CAS  PubMed  PubMed Central  Google Scholar