Ehrman RR, Sullivan AN, Favot MJ, Sherwin RL, Reynolds CA, Abidov A et al (2018) Pathophysiology, echocardiographic evaluation, biomarker findings, and prognostic implications of septic cardiomyopathy: a review of the literature. Critical Care (London, England) 22:112

Article  Google Scholar 

Martin L, Derwall M, Al Zoubi S, Zechendorf E, Reuter DA, Thiemermann C et al (2019) The septic heart: current understanding of molecular mechanisms and clinical implications. Chest 155:427–437

PubMed  Article  Google Scholar 

Parker MM, Shelhamer JH, Bacharach SL, Green MV, Natanson C, Frederick TM et al (1984) Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100:483–490

CAS  PubMed  Article  Google Scholar 

Weisel RD, Vito L, Dennis RC, Valeri CR, Hechtman HB (1977) Myocardial depression during sepsis. Am J Surg 133:512–521

CAS  PubMed  Article  Google Scholar 

Ikonomidis I, Nikolaou M, Dimopoulou I, Paraskevaidis I, Lekakis J, Mavrou I et al (2010) Association of left ventricular diastolic dysfunction with elevated NT-pro-BNP in general intensive care unit patients with preserved ejection fraction: a complementary role of tissue Doppler imaging parameters and NT-pro-BNP levels for adverse outcome. Shock (Augusta, Ga) 33:141–148

Article  Google Scholar 

Landesberg G, Gilon D, Meroz Y, Georgieva M, Levin PD, Goodman S et al (2012) Diastolic dysfunction and mortality in severe sepsis and septic shock. Eur Heart J 33:895–903

CAS  PubMed  Article  Google Scholar 

Landesberg G, Jaffe AS, Gilon D, Levin PD, Goodman S, Abu-Baih A et al (2014) Troponin elevation in severe sepsis and septic shock: the role of left ventricular diastolic dysfunction and right ventricular dilatation*. Crit Care Med 42:790–800

CAS  PubMed  Article  Google Scholar 

Pulido JN, Afessa B, Masaki M, Yuasa T, Gillespie S, Herasevich V et al (2012) Clinical spectrum, frequency, and significance of myocardial dysfunction in severe sepsis and septic shock. Mayo Clin Proc 87:620–628

PubMed  PubMed Central  Article  Google Scholar 

Sturgess DJ, Marwick TH, Joyce C, Jenkins C, Jones M, Masci P et al (2010) Prediction of hospital outcome in septic shock: a prospective comparison of tissue Doppler and cardiac biomarkers. Critical care (London, England) 14:R44

Article  Google Scholar 

Zaky A, Gill EA, Lin CP, Paul CP, Bendjelid K, Treggiari MM (2016) Characteristics of sepsis-induced cardiac dysfunction using speckle-tracking echocardiography: a feasibility study. Anaesth Intensive Care 44:65–76

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD et al (2015) Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 372:1301–1311

CAS  PubMed  Article  Google Scholar 

Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ et al (2014) Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371:1496–1506

CAS  PubMed  Article  Google Scholar 

Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F et al (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:1683–1693

CAS  PubMed  Article  Google Scholar 

https://grants.nih.gov/grants/guide/notice-files/NOT-GM-19-054.html. Accessed 26 Jan 2022

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP (2007) Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ 335:806–808

Article  Google Scholar 

Lanspa MJ, Gutsche AR, Wilson EL, Olsen TD, Hirshberg EL, Knox DB et al (2016) Application of a simplified definition of diastolic function in severe sepsis and septic shock. Critical Care (London, England) 20:243

Article  Google Scholar 

Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T et al (2016) Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 29:277–314

PubMed  Article  Google Scholar 

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L et al (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 16:233–270

PubMed  Article  Google Scholar 

Gilbert EH, Lowenstein SR, Koziol-McLain J, Barta DC, Steiner J (1996) Chart reviews in emergency medicine research: Where are the methods? Ann Emerg Med 27:305–308

CAS  PubMed  Article  Google Scholar 

Lambden S, Laterre PF, Levy MM, Francois B (2019) The SOFA score-development, utility and challenges of accurate assessment in clinical trials. Critical Care (London, England) 23:374

Article  Google Scholar 

Harrell FE (2015) General aspects of fitting regression models. In: Harrell FE (ed) Regression modeling strategies. Springer series in statistics. Springer, Cham

Google Scholar 

Martin L, Derwall M, Al Zoubi S, Zechendorf E, Reuter DA, Thiemermann C et al (2018) The septic heart: current understanding of molecular mechanisms and clinical implications. Chest. https://doi.org/10.1016/j.chest.2018.08.1037

Article  PubMed  PubMed Central  Google Scholar 

Beesley SJ, Weber G, Sarge T, Nikravan S, Grissom CK, Lanspa MJ et al (2018) Septic cardiomyopathy. Crit Care Med 46:625–634

PubMed  Article  Google Scholar 

Huang SJ, Nalos M, McLean AS (2013) Is early ventricular dysfunction or dilatation associated with lower mortality rate in adult severe sepsis and septic shock? A meta-analysis. Critical Care (London, England) 17:R96

Article  Google Scholar 

Sevilla Berrios RA, O’Horo JC, Velagapudi V, Pulido JN (2014) Correlation of left ventricular systolic dysfunction determined by low ejection fraction and 30-day mortality in patients with severe sepsis and septic shock: a systematic review and meta-analysis. J Crit Care 29:495–499

PubMed  Article  Google Scholar 

Kakihana Y, Ito T, Nakahara M, Yamaguchi K, Yasuda T (2016) Sepsis-induced myocardial dysfunction: pathophysiology and management. J Intensive Care 4:22

PubMed  PubMed Central  Article  Google Scholar 

Marik PE, Lemson J (2014) Fluid responsiveness: an evolution of our understanding. Br J Anaesth 112:617–620

CAS  PubMed  Article  Google Scholar 

Ehrman RR, Ottenhoff JD, Favot MJ, Harrison NE, Khait L, Welch RD et al (2022) Do septic patients with reduced left ventricular ejection fraction require a low-volume resuscitative strategy? Am J Emerg Med 52:187–190

PubMed  Article  Google Scholar 

Cioccari L, Luethi N, Masoodi M (2020) Lipid mediators in critically Ill patients: a step towards precision medicine. Front Immunol 11:599853

CAS  PubMed  PubMed Central  Article  Google Scholar 

Dalli J, Colas RA, Quintana C, Barragan-Bradford D, Hurwitz S, Levy BD et al (2017) Human sepsis eicosanoid and proresolving lipid mediator temporal profiles: correlations with survival and clinical outcomes. Crit Care Med 45:58–68

CAS  PubMed  PubMed Central  Article  Google Scholar 

Boissier F, Razazi K, Seemann A, Bedet A, Thille AW, de Prost N et al (2017) Left ventricular systolic dysfunction during septic shock: the role of loading conditions. Intensive Care Med 43:633–642

PubMed  Article  Google Scholar 

Kalam K, Otahal P, Marwick TH (2014) Prognostic implications of global LV dysfunction: a systematic review and meta-analysis of global longitudinal strain and ejection fraction. Heart (British Cardiac Society) 100:1673–1680

Google Scholar 

Chang WT, Lee WH, Lee WT, Chen PS, Su YR, Liu PY et al (2015) Left ventricular global longitudinal strain is independently associated with mortality in septic shock patients. Intensive Care Med 41:1791–1799

PubMed  Article  Google Scholar 

Palmieri V, Innocenti F, Guzzo A, Guerrini E, Vignaroli D, Pini R (2015) Left ventricular systolic longitudinal function as predictor of outcome in patients with sepsis. Circ Cardiovasc Imaging 8:e003865 (discussion e)

PubMed  Article  Google Scholar 

De Geer L, Engvall J, Oscarsson A (2015) Strain echocardiography in septic shock—a comparison with systolic and diastolic function parameters, cardiac biomarkers and outcome. Critical Care (London, England) 19:122

Article  Google Scholar 

Orde SR, Pulido JN, Masaki M, Gillespie S, Spoon JN, Kane GC et al (2014) Outcome prediction in sepsis: speckle tracking echocardiography based assessment of myocardial function. Critical Care (London, England) 18:R149

Article  Google Scholar 

Budinger GR, Duranteau J, Chandel NS, Schumacker PT (1998) Hibernation during hypoxia in cardiomyocytes. Role of mitochondria as the O2 sensor. J Biol Chem 273:3320–3326

CAS  PubMed  Article  Google Scholar 

Levy RJ, Piel DA, Acton PD, Zhou R, Ferrari VA, Karp JS et al (2005) Evidence of myocardial hibernation in the septic heart. Crit Care Med 33:2752–2756

PubMed  Article  Google Scholar 

Siddiqui Y, Crouser ED, Raman SV (2013) Nonischemic myocardial changes detected by cardiac magnetic resonance in critical care patients with sepsis. Am J Respir Crit Care Med 188:1037–1039

PubMed  PubMed Central  Article  Google Scholar 

Rolando G, Espinoza ED, Avid E, Welsh S, Pozo JD, Vazquez AR et al (2015) Prognostic value of ventricular diastolic dysfunction in patients with severe sepsis and septic shock. Rev Bras Ter Intensiva 27:333–339

PubMed  PubMed Central  Article  Google Scholar 

Brown SM, Pittman JE, Hirshberg EL, Jones JP, Lanspa MJ, Kuttler KG et al (2012) Diastolic dysfunction and mortality in early severe sepsis and septic shock: a prospective, observational echocardiography study. Crit Ultrasound J 4:8

PubMed  PubMed Central  Article  Google Scholar 

Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD et al (2009) International study of the prevalence and outcomes of infection in intensive care units. JAMA 302:2323–2329

CAS  PubMed