Normative values for body surface gastric mapping evaluations of gastric motility using Gastric Alimetry: spectral analysis

Abstract

Introduction Body surface gastric mapping (BSGM) is a new non-invasive test of gastric function. BSGM offers several novel and improved biomarkers of gastric function capable of differentiating patients with overlapping symptom-profiles. The aim of this study was to define normative reference intervals for BSGM spectral metrics in a population of healthy controls. Methods BSGM was performed in healthy controls using Gastric Alimetry (Alimetry, New Zealand) comprising a stretchable high-resolution array (8x8 electrodes; 196 cm2), wearable Reader, and validated symptom-logging App. The evaluation encompassed a fasting baseline (30 min), 482 kCal meal, and 4-hr postprandial recording. Normative reference intervals were calculated for BSGM metrics including the Principal Gastric Frequency, Gastric Alimetry Rhythm Index (GA-RI; a measure of the concentration of power in the gastric frequency band over time), BMI-adjusted amplitude (microvolt), and fed:fasted amplitude ratio (ff-AR). Data are reported as median and reference interval (5th and/or 95th percentiles). Results 110 subjects (55% female, median age 32 (IQR 24 - 50), median BMI 23.8 kg/m2 (IQR 21.4 - 26.9)) were included. The median Principal Gastric Frequency was 3.04 cpm; reference interval: 2.65 - 3.35 cpm. Median GA-RI was 0.50; reference interval: >=0.25. Median BMI-adjusted amplitude was 37.6 microvolts; reference interval: 20-70 microvolts. The median ff-AR was 1.85; reference interval >=1.08. Higher BMI was associated with a shorter meal-response duration (p=0.014). Conclusions This study provides normative reference intervals for BSGM spectral data that will be used in clinical practice to inform diagnostic interpretations of abnormal gastric function.

Competing Interest Statement

AG, CNA, and GO hold grants and intellectual property in the field of GI electrophysiology and are members of University of Auckland spin-out companies: The Insides Company (GO), FlexiMap (PD), and Alimetry (GS, SC, SW, JW, CD, PD, CNA, GO, AG). The remaining authors have no relevant conflicts to declare.

Funding Statement

This work was supported by the New Zealand Health Research Council, the National Institutes of Health (R56 DK126935), and the Royal Australasian College of Surgeons John Mitchell Crouch Fellowship.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

This was an observational cohort study conducted in Auckland (New Zealand), Calgary (Canada), Louisville (KY, USA) and Western Sydney (Australia); Ethical approvals: The Auckland Health Research Ethics Committee (AHREC; AH1130), The University of Calgary Conjoint Health Research Ethics Board (REB19-1925), Human Research Ethics Committee at Western Sydney (H13541), and University of Louisville IRB (Ref 723369).

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes

Data Availability

Data are available on request from the corresponding author.

留言 (0)

沒有登入
gif