Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions

Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Sci Adv. 2020;6(28):eaba1983. https://doi.org/10.1126/sciadv.aba1983.

Arango D, Sturgill D, Alhusaini N, Dillman AA, Sweet TJ, Hanson G, Hosogane M, Sinclair WR, Nanan KK, Mandler MD, Fox SD, Zengeya TT, Andresson T, Meier JL, Coller J, Oberdoerffer S. Acetylation of cytidine in mRNA promotes translation efficiency. Cell. 2018;175(7):1872-1886.e24. https://doi.org/10.1016/j.cell.2018.10.030.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bouchardy C, Mitrunen K, Wikman H, Husgafvel-Pursiainen K, Dayer P, Benhamou S, Hirvonen A. N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk. Pharmacogenetics. 1998;8(4):291–8. https://doi.org/10.1097/00008571-199808000-00002.

CAS  Article  PubMed  Google Scholar 

Cai S, Liu X, Zhang C, Xing B, Du X. Autoacetylation of NAT10 is critical for its function in rRNA transcription activation. Biochem Biophys Res Commun. 2017;483(1):624–9. https://doi.org/10.1016/j.bbrc.2016.12.092.

CAS  Article  PubMed  Google Scholar 

Chang J, Chen Z, Zhao R, Nie HG, Ji HL. Ion transport mechanisms for smoke inhalation-injured airway epithelial barrier. Cell Biol Toxicol. 2020;36(6):571–89. https://doi.org/10.1007/s10565-020-09545-1.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Dalhat MH, Altayb HN, Khan MI, Choudhry H. Structural insights of human N-acetyltransferase 10 and identification of its potential novel inhibitors. Sci Rep. 2021;11(1):6051. https://doi.org/10.1038/s41598-021-84908-0.

CAS  Article  PubMed  PubMed Central  Google Scholar 

de Jong TV, Moshkin YM, Guryev V. Gene expression variability: the other dimension in transcriptome analysis. Physiol Genomics. 2019;51(5):145–58. https://doi.org/10.1152/physiolgenomics.00128.2018.

CAS  Article  PubMed  Google Scholar 

Guo G, Shi X, Wang H, Ye L, Tong X, Yan K, Ding N, Chen C, Zhang H, Xue X. Epitranscriptomic N4-acetylcytidine profiling in CD4+ T cells of systemic lupus erythematosus. Front Cell Dev Biol. 2020;8:842. https://doi.org/10.3389/fcell.2020.00842.

Article  PubMed  PubMed Central  Google Scholar 

Hou J, Cao X, Cheng Y, Wang X. Roles of TP53 gene in the development of resistance to PI3K inhibitor resistances in CRISPR-Cas9-edited lung adenocarcinoma cells. Cell Biol Toxicol. 2020;36(5):481–92. https://doi.org/10.1007/s10565-020-09523-7.

CAS  Article  PubMed  Google Scholar 

Hsia TC, Chung JG, Lu HF, Ho HC, Yang CC, Lu KH, Hung CF. The effect of paclitaxel on 2-aminofluorene-DNA adducts formation and arylamine N-acetyltransferase activity and gene expression in human lung tumor cells (A549). Food Chem Toxicol. 2002;40(5):697–703. https://doi.org/10.1016/s0278-6915(01)00128-4.

CAS  Article  PubMed  Google Scholar 

Ito S, Horikawa S, Suzuki T, Kawauchi H, Tanaka Y, Suzuki T, Suzuki T Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA) J Biol Chem. 2014;289:35724–35730.

Jin G, Xu M, Zou M, Duan S. The processing, gene regulation, biological functions, and clinical relevance of N4-acetylcytidine on RNA: a systematic review. Mol Ther Nucleic Acids. 2020;20:13–24. https://doi.org/10.1016/j.omtn.2020.01.037.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Kasper M, Barth K. Potential contribution of alveolar epithelial type I cells to pulmonary fibrosis. Biosci Rep. 2017;37(6):BSR20171301. https://doi.org/10.1042/BSR20171301.

Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, et al. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Nat Commun. 2016;7:11612. https://doi.org/10.1038/ncomms11612.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Kim N, Kim HK, Lee K, Hong Y, Cho JH, Choi JW, Lee JI, Suh YL, Ku BM, Eum HH, Choi S, Choi YL, Joung JG, Park WY, Jung HA, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ, Lee HO. Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma. Nat Commun. 2020;11(1):2285. https://doi.org/10.1038/s41467-020-16164-1.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Laanesoo A, Urgard E, Periyasamy K, Laan M, Bochkov YA, Aab A, Magilnick N, Pooga M, Gern JE, Johnston SL, Coquet JM, Boldin MP, Wengel J, Altraja A, Bochenek G, Jakiela B, Rebane A. Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation. Clin Transl Med. 2021;11(6): e427. https://doi.org/10.1002/ctm2.427.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, Bassez A, Decaluwé H, Pircher A, Van den Eynde K, Weynand B, Verbeken E, De Leyn P, Liston A, Vansteenkiste J, Carmeliet P, Aerts S, Thienpont B. Phenotype molding of stromal cells in the lung tumor microenvironment. Nat Med. 2018;24(8):1277–89. https://doi.org/10.1038/s41591-018-0096-5.

CAS  Article  PubMed  Google Scholar 

Larrieu D, Britton S, Demir M, Rodriguez R, Jackson SP. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014;344(6183):527–32. https://doi.org/10.1126/science.1252651.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Lee CC, Cheng YC, Chang CY, Lin CM, Chang JY. Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption. Sci Rep. 2018;8(1):17477. https://doi.org/10.1038/s41598-018-35392-6.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, Deng H, Luo J, Ke Y, Du X. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016;17(3):349–66. https://doi.org/10.15252/embr.201540505.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Liu X, Cai S, Zhang C, Liu Z, Luo J, Xing B, Du X. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucleic Acids Res. 2018;46(18):9601–16. https://doi.org/10.1093/nar/gky777.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Liu HY, Liu YY, Yang F, Zhang L, Zhang FL, Hu X, Shao ZM, Li DQ. Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer. Nucleic Acids Res. 2020;48(7):3638–56. https://doi.org/10.1093/nar/gkaa130.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Lv J, Liu H, Wang Q, Tang Z, Hou L, Zhang B. Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT. Biochem Biophys Res Commun. 2003;311(2):506–13.

Article  Google Scholar 

Mitani A, Ito K, Vuppusetty C, Barnes PJ, Mercado N. Restoration of corticosteroid sensitivity in chronic obstructive pulmonary disease by inhibition of mammalian target of rapamycin. Am J Respir Crit Care Med. 2016;193(2):143–53. https://doi.org/10.1164/rccm.201503-0593OC.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Morse C, Tabib T, Sembrat J, Buschur KL, Bittar HT, Valenzi E, Jiang Y, Kass DJ, Gibson K, Chen W, Mora A, Benos PV, Rojas M, Lafyatis R. Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis. Eur Respir J. 2019;54(2):1802441. https://doi.org/10.1183/13993003.02441-2018.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Peliciari-Garcia RA, Marçal AC, Silva JA, Carmo-Buonfiglio D, Amaral FG, Afeche SC, Cipolla-Neto J, Carvalho CR. Insulin temporal sensitivity and its signaling pathway in the rat pineal gland. Life Sci. 2010;87(5–6):169–74. https://doi.org/10.1016/j.lfs.2010.06.005.

CAS  Article  PubMed  Google Scholar 

Pelizzo G, Collura M, Puglisi A, Pappalardo MP, Agolini E, Novelli A, Piccione M, Cacace C, Bussani R, Corsello G, Calcaterra V. Congenital emphysematous lung disease associated with a novel Filamin A mutation. Case report and literature review. BMC Pediatr. 2019;19(1):86. https://doi.org/10.1186/s12887-019-1460-4.

Rao DD, Vorhies JS, Senzer N, Nemunaitis J. siRNA vs. shRNA: similarities and differences. Adv Drug Deliv Rev. 2009;61(9):746–59. https://doi.org/10.1016/j.addr.2009.04.004.

Rock JR, Onaitis MW, Rawlins EL, Lu Y, Clark CP, Xue Y, Randell SH, Hogan BL. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A. 2009;106(31):12771–5. https://doi.org/10.1073/pnas.0906850106.

Article  PubMed  PubMed Central  Google Scholar 

Sas-Chen A, Thomas JM, Matzov D, Taoka M, Nance KD, Nir R, et al. Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature. 2020;583(7817):638–43. https://doi.org/10.1038/s41586-020-2418-2.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Shen Q, Zheng X, McNutt MA, Guang L, Sun Y, Wang J, Gong Y, Hou L, Zhang B. NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules. Exp Cell Res. 2009;315(10):1653–67. https://doi.org/10.1016/j.yexcr.2009.03.007.

CAS  Article  PubMed  Google Scholar 

Shi L, Hou J, Wang L, Fu H, Zhang Y, Song Y, Wang X. Regulatory roles of osteopontin in human lung cancer cell epithelial-to-mesenchymal transitions and responses. Clin Transl Med. 2021;11(7): e486. https://doi.org/10.1002/ctm2.486.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Song D, Tang L, Wang L, Huang J, Zeng T, Fang H, Wang X. Roles of TGFβ1 in the expression of phosphoinositide 3-kinase isoform genes and sensitivity and response of lung telocytes to PI3K inhibitors. Cell Biol Toxicol. 2020;36(1):51–64. https://doi.org/10.1007/s10565-019-09487-3.

CAS  Article  PubMed  Google Scholar 

Song D, Yan F, Fu H, Li L, Hao J, Zhu Z, Ye L, Zhang Y, Jin M, Dai L, Fang H, Song Z, Wu D, Wang X. A cellular census of human peripheral immune cells identifies novel cell states in lung diseases. Clin Transl Med. 2021;11(11): e579. https://doi.org/10.1002/ctm2.579.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Tan Y, Zheng J, Liu X, Lu M, Zhang C, Xing B, Du X. Loss of nucleolar localization of NAT10 promotes cell migration and invasion in hepatocellular carcinoma. Biochem Biophys Res Commun. 2018;499(4):1032–8. https://doi.org/10.1016/j.bbrc.2018.04.047.

CAS  Article  PubMed  Google Scholar 

Valenzi E, Bulik M, Tabib T, Morse C, Sembrat J, Trejo Bittar H, Rojas M, Lafyatis R. Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease. Ann Rheum Dis. 2019;78(10):1379–87. https://doi.org/10.1136/annrheumdis-2018-214865

留言 (0)

沒有登入
gif