Association of multiple sclerosis with mortality in sepsis: a population-level analysis

Wallin MT, Culpepper WJ, Campbell JD, Nelson LM, Langer-Gould A, Marrie RA, Cutter GR, Kaye WE, Wagner L, Tremlett H, Buka SL, Dilokthornsakul P, Topol B, Chen LH, LaRocca NG, US Multiple Sclerosis Prevalence Workgroup. The prevalence of MS in the United States: a population-based estimate using health claims data. Neurology. 2019;92:e1029–40.

Article  Google Scholar 

Kingwell E, van der Kop M, Zhao Y, Shirani A, Zhu F, Oger J, Tremlett H. Relative mortality and survival in multiple sclerosis: findings from British Columbia, Canada. J Neurol Neurosurg Psychiatry. 2012;83:61–6.

CAS  Article  Google Scholar 

DeSèze M, Ruffion A, Denys P, Joseph PA, Perrouin-Verbe B, GENULF. The neurogenic bladder in multiple sclerosis: review of the literature and proposal of management guidelines. Mult Scler. 2007;13:915–28.

Article  Google Scholar 

Srour N, LeBlanc C, King J, McKim DA. Lung volume recruitment in multiple sclerosis. PLoS ONE. 2013;8: e56676.

CAS  Article  Google Scholar 

Winkelmann A, Loebermann M, Reisinger EC, Zettl UK. Multiple sclerosis treatment and infectious issues: update 2013. Clin Exp Immunol. 2014;175:425–38.

CAS  Article  Google Scholar 

Nelson RE, Xie Y, DuVall SL, Butler J, Kamauu AWC, Knippenberg K, Schuerch M, Foskett N, LaFleur J. Multiple sclerosis and risk of infection-related hospitalization and death in US veterans. Int J MS Care. 2015;17:221–30.

Article  Google Scholar 

Marrie RA, Bernstein CN, Peschken CA, Hitchon CA, Chen H, Fransoo R, Garland A. Intensive care unit admission in multiple sclerosis: increased incidence and increased mortality. Neurology. 2014;82:2112–9.

Article  Google Scholar 

Goodin DS, Corwin M, Kaufman D, Golub H, Reshef S, Rametta MJ, Knappertz V, Cutter G, Pleimes D. Causes of death among commercially insured multiple sclerosis patients in the United States. PLoS ONE. 2014;9: e105207.

Article  Google Scholar 

Harding K, Zhu F, Alotaibi M, Duggan T, Tremlett H, Kingwell E. Multiple cause of death analysis in multiple sclerosis: a population-based study. Neurology. 2020;94:e820–9.

Article  Google Scholar 

Capkun G, Dahlke F, Lahoz R, Nordstrom B, Tilson HH, Cutter G, Bischof D, Moore A, Simeone J, Fraeman K, Bancken F, Geissbühler Y, Wagner M, Cohan S. Mortality and comorbidities in patients with multiple sclerosis compared with a population without multiple sclerosis: An observational study using the US Department of Defense administrative claims database. Mult Scler Relat Disord. 2015;4:546–54.

Article  Google Scholar 

Sheth M, Benedum CM, Celi LA, Mark RG, Markuzon N. The association between autoimmune disease and 30-day mortality among sepsis ICU patients: a cohort study. Crit Care. 2019;23:93.

Article  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med. 2007;4:e296.

Article  Google Scholar 

Texas inpatient public use data file. Texas Department of State Health Services, Center for Health Statistics, Austin, Texas. 2018. http://www.dshs.state.tx.us/thcic/hospitals/Inpatientpudf.shtm. Accessed 23 July 2021

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801–10.

CAS  Article  Google Scholar 

Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, Jernigan JA, Martin GS, Septimus E, Warren DK, Karcz A, Chan C, Menchaca JT, Wang R, Gruber S, Klompas M, CDC Prevention Epicenter Program. Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009–2014. JAMA. 2017;318:1241–9.

Article  Google Scholar 

Prescott HC, Cope TM, Gesten FC, Ledneva TA, Friedrich ME, Iwashyna TJ, Osborn TM, Seymour CW, Levy MM. Reporting of sepsis cases for performance measurement versus for reimbursement in New York State. Crit Care Med. 2018;46:666–73.

Article  Google Scholar 

Buchman TG, Simpson SQ, Sciarretta KL, Finne KP, Sowers N, Collier M, Chavan S, Oke I, Pennini ME, Santhosh A, Wax M, Woodbury R, Chu S, Merkeley TG, Disbrow GL, Bright RA, MaCurdy TE, Kelman JA. Sepsis among medicare beneficiaries: 1. The burdens of sepsis, 2012–2018. Crit Care Med. 2020;48:276–88.

Article  Google Scholar 

Nusrat S, Levinthal D, Bielefeldt K. Hospitalization rates and discharge status in multiple sclerosis. Mult Scler Int. 2013;2013: 436929.

PubMed  PubMed Central  Google Scholar 

Afzal MR, Yao J, Bandaru H, Qureshi M, Ghatali M, Vellipuram A, Khatri RA, Kassar D, Maud A, Rodriguez G, Cruz-Flores S. Multiple sclerosis (MS) and neuromyelitis optica (NMO): admission trends, in-hospital events, outcomes, treatment and regional differences in distribution: a study of the national inpatient sample 2006–2014. Neurology. 2019;92(15 Supplement):42–064.

Google Scholar 

Sakr Y, Jaschinski U, Wittebole X, Szakmany T, Lipman J, Ñamendys-Silva SA, Martin-Loeches I, Leone M, Lupu MN, Vincent JL, ICON Investigators. Sepsis in intensive care unit patients: worldwide data from the intensive care over nations audit. Open Forum Infect Dis. 2018;5:313.

Article  Google Scholar 

Kumar G, Kumar N, Taneja A, Kaleekal T, Tarima S, McGinley E, Jimenez E, Mohan A, Khan RA, Whittle J, Jacobs E, Nanchal R, Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators. Nationwide trends of severe sepsis in the 21st century (2000–2007). Chest. 2011;140:1223–31.

Article  Google Scholar 

Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303–10.

CAS  Article  Google Scholar 

Quan H, Sundararajan V, Halfon P, Fong A, Burnand B, Luthi JC, Saunders LD, Beck CA, Feasby TE, Ghali WA. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care. 2005;43:1130–9.

Article  Google Scholar 

Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, Januel JM, Sundararajan V. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173:676–82.

Article  Google Scholar 

Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546–54.

Article  Google Scholar 

Anesi GL, Liu VX, Chowdhury M, Small DS, Wang W, Delgado MK, Bayes B, Dress E, Escobar GJ, Halpern SD. Association of ICU admission and outcomes in sepsis and acute respiratory failure. Am J Respir Crit Care Med. 2022;205:520–8.

Article  Google Scholar 

Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013;13:862–74.

CAS  Article  Google Scholar 

Schulte W, Bernhagen J, Bucala R. Cytokines in sepsis: potent immunoregulators and potential therapeutic targets–an updated view. Mediators Inflamm. 2013;2013: 165974.

Article  Google Scholar 

Davidson A, Diamond B. Autoimmune diseases. N Engl J Med. 2001;345:340–50.

CAS  Article  Google Scholar 

Santamaria P. Cytokines and chemokines in autoimmune disease: an overview. Adv Exp Med Biol. 2003;520:1–7.

CAS  Article  Google Scholar 

Balashov KE, Smith DR, Khoury SJ, Hafler DA, Weiner HL. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proc Natl Acad Sci USA. 1997;94:599–603.

CAS  Article  Google Scholar 

Göbel K, Ruck T, Meuth SG. Cytokine signaling in multiple sclerosis: lost in translation. Mult Scler. 2018;24:432–9.

Article  Google Scholar 

Kantarci OH, Hebrink DD, Schaefer-Klein J, Sun Y, Achenbach S, Atkinson EJ, Heggarty S, Cotleur AC, de Andrade M, Vandenbroeck K, Pelfrey CM, Weinshenker BG. Interferon gamma allelic variants: sex-biased multiple sclerosis susceptibility and gene expression. Arch Neurol. 2008;65:349–57.

PubMed  Google Scholar 

Petereit HF, Pukrop R, Fazekas F, Bamborschke SU, Röpele S, Kölmel HW, Merkelbach S, Japp G, Jongen PJ, Hartung HP, Hommes OR. Low interleukin-10 production is associated with higher disability and MRI lesion load in secondary progressive multiple sclerosis. J Neurol Sci. 2003;206:209–14.

CAS  Article  Google Scholar 

Reddy RC, Chen GH, Newstead MW, Moore T, Zeng X, Tateda K, Standiford TJ. Alveolar macrophage deactivation in murine septic peritonitis: role of interleukin 10. Infect Immun. 2001;69(3):1394–401.

CAS  Article  Google Scholar 

Reddy RC, Chen GH, Tekchandani PK, Standiford TJ. Sepsis-induced immunosuppression: from bad to worse. Immunol Res. 2001;24:273–87.

CAS  Article  Google Scholar 

Ono S, Ueno C, Aosasa S, Tsujimoto H, Seki S, Mochizuki H. Severe sepsis induces deficient interferon-gamma and interleukin-12 production, but interleukin-12 therapy improves survival in peritonitis. Am J Surg. 2001;182:491–7.

CAS  Article  Google Scholar 

Dema M, Eixarch H, Villar LM, Montalban X, Espejo C. Immunosenescence in multiple sclerosis: the identification of new therapeutic targets. Autoimmun Rev. 2021;20: 102893.

CAS  Article  Google Scholar 

Baghela A, Pena OM, Lee AH, Baquir B, Falsafi R, An A, Farmer SW, Hurlburt A, Mondragon-Cardona A, Rivera JD, Baker A, Trahtemberg U, Shojaei M, Jimenez-Canizales CE, Dos Santos CC, Tang B, Bouma HR, Cohen Freue GV, Hancock REW. Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures. EBioMedicine. 2022;75: 103776.

CAS  Article  Google Scholar 

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