World Health Organization (2020) The top 10 causes of death. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Accessed 26 Sep 2021.
World Health Organization (2021) Cardiovascular diseases (CVDs). https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds). Accessed 26 Sep 2021.
Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2018;39:119–77. https://doi.org/10.1093/eurheartj/ehx393.
Ferrari R, Biscaglia S, Malagù M, et al. Can we improve myocardial protection during ischaemic injury? Cardiol. 2016;135:14–26. https://doi.org/10.1159/000444847.
Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357:1121–35. https://doi.org/10.1016/S1520-765X(02)90013-1.
CAS Article PubMed Google Scholar
Eitel I, Stiermaier T, Lange T, et al. Cardiac magnetic resonance myocardial feature tracking for optimized prediction of cardiovascular events following myocardial infarction. JACC Cardiovasc Imaging. 2018;11:1433–44. https://doi.org/10.1016/j.jcmg.2017.11.034.
Bulluck H, Yellon DM, Hausenloy DJ. Reducing myocardial infarct size: challenges and future opportunities. Heart. 2016;102:341–8. https://doi.org/10.1136/heartjnl-2015-307855.
CAS Article PubMed Google Scholar
Rossello X, Lobo-Gonzalez M, Ibanez B. Editor’s choice—pathophysiology and therapy of myocardial ischaemia/reperfusion syndrome. Eur Hear J Acute Cardiovasc Care. 2019;8:443–56. https://doi.org/10.1177/2048872619845283.
Tratsiakovich Y, Yang J, Gonon AT, et al. Arginase as a target for treatment of myocardial ischemia-reperfusion injury. Eur J Pharmacol. 2013;720:121–3. https://doi.org/10.1016/j.ejphar.2013.10.040.
CAS Article PubMed Google Scholar
Ferreira R, Burgos M, Llesuy S, et al. Reduction of reperfusion injury with mannitol cardioplegia. Ann Thorac Surg. 1989;48:77–83. https://doi.org/10.1016/0003-4975(89)90182-3.
CAS Article PubMed Google Scholar
Rodrigo R, González-Montero J, Sotomayor CG. Novel combined antioxidant strategy against hypertension, acute myocardial infarction and postoperative atrial fibrillation. Biomedicines. 2021;9:1–20. https://doi.org/10.3390/biomedicines9060620.
Hausenloy DJ, Botker HE, Condorelli G, et al. Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res. 2013;98:7–27. https://doi.org/10.1093/cvr/cvt004.
CAS Article PubMed Google Scholar
Davidson SM, Ferdinandy P, Andreadou I, et al. Multitarget strategies to reduce myocardial ischemia/reperfusion injury: JACC review topic of the week. J Am Coll Cardiol. 2019;73:89–99. https://doi.org/10.1016/j.jacc.2018.09.086.
Parra-Flores P, Riquelme JA, Valenzuela-Bustamante P, et al. The association of ascorbic acid, deferoxamine and N-acetylcysteine improves cardiac fibroblast viability and cellular function associated with tissue repair damaged by simulated ischemia/reperfusion. Antioxidants. 2019;8:1–19. https://doi.org/10.3390/antiox8120614.
Rodrigo R, Prieto JC, Castillo R. Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n-3 fatty acids: molecular mechanisms and potential clinic applications. Clin Sci. 2013;124:1–15. https://doi.org/10.1042/CS20110663.
Spoelstra-de Man AME, Elbers PWG, Oudemans-van Straaten HM. Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury. Crit Care. 2018. https://doi.org/10.1186/s13054-018-1996-y.
Article PubMed PubMed Central Google Scholar
Pasupathy S, Tavella R, Grover S, et al. Early use of N-acetylcysteine with nitrate therapy in patients undergoing primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction reduces myocardial infarct size (the NACIAM trial [N-acetylcysteine in acute myocardial inf. Circulation. 2017;136:894–903. https://doi.org/10.1161/CIRCULATIONAHA.117.027575.
CAS Article PubMed Google Scholar
García Pérez A, Mora Viera L, Abreu Reyes D. La N-acetilcisteína reduce el progreso de daño cardíaco en modelos experimentales. CorSalud. 2020;12:214–8.
Tang LJ, Luo XJ, Tu H, et al. Ferroptosis occurs in phase of reperfusion but not ischemia in rat heart following ischemia or ischemia/reperfusion. Naunyn Schmiedebergs Arch Pharmacol. 2020;394:401–10. https://doi.org/10.1007/s00210-020-01932-z.
CAS Article PubMed Google Scholar
Rodrigo R, Prieto JC, Aguayo R, et al. Joint cardioprotective effect of vitamin c and other antioxidants against reperfusion injury in patients with acute myocardial infarction undergoing percutaneous coronary intervention. Molecules. 2021;26:1–27. https://doi.org/10.3390/molecules26185702.
González-Montero J, Brito R, Gajardo AI, Rodrigo R. Myocardial reperfusion injury and oxidative stress: therapeutic opportunities. World J Cardiol. 2018;10:74–86. https://doi.org/10.4330/wjc.v10.i9.74.
Article PubMed PubMed Central Google Scholar
Peoples JN, Saraf A, Ghazal N, et al. Mitochondrial dysfunction and oxidative stress in heart disease. Exp Mol Med. 2019. https://doi.org/10.1038/s12276-019-0355-7.
Article PubMed PubMed Central Google Scholar
Chen Z, Chua CC, Gao J, et al. Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1. J Pineal Res. 2009;46:235–41. https://doi.org/10.1111/j.1600-079X.2008.00654.x.
CAS Article PubMed Google Scholar
Kurian GA, Rajagopal R, Vedantham S, Rajesh M. The role of oxidative stress in myocardial ischemia and reperfusion injury and remodeling: revisited. Oxid Med Cell Longev. 2016. https://doi.org/10.1155/2016/1656450.
Article PubMed PubMed Central Google Scholar
Wang BF, Yoshioka J. The emerging role of thioredoxin-interacting protein in myocardial ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 2017;22:219–29. https://doi.org/10.1177/1074248416675731.
CAS Article PubMed Google Scholar
Huang X-S, Chen H-P, Yu H-H, et al. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection. Mol Cell Biochem. 2014;385:33–41. https://doi.org/10.1007/s11010-013-1812-6.
CAS Article PubMed Google Scholar
Stanley BA, Sivakumaran V, Shi S, et al. Thioredoxin reductase-2 is essential for keeping low levels of H2O2 emission from isolated heart mitochondria. J Biol Chem. 2011;286:33669–77. https://doi.org/10.1074/jbc.M111.284612.
CAS Article PubMed PubMed Central Google Scholar
Guan W, Osanai T, Kamada T, et al. Time course of free radical production after primary coronary angioplasty for acute myocardial infarction and the effect of vitamin C. Jpn Circ J. 1999;63:924–8. https://doi.org/10.1253/jcj.63.924.
CAS Article PubMed Google Scholar
Ramos C, Brito R, González-Montero J, et al. Effects of a novel ascorbate-based protocol on infarct size and ventricle function in acute myocardial infarction patients undergoing percutaneous coronary angioplasty. Arch Med Sci. 2017;13:558–67. https://doi.org/10.5114/aoms.2016.59713.
CAS Article PubMed Google Scholar
Khan SA, Bhattacharjee S, Ghani MOA, et al. Vitamin c for cardiac protection during percutaneous coronary intervention: a systematic review of randomized controlled trials. Nutrients. 2020;12:1–21. https://doi.org/10.3390/nu12082199.
Becker LB. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res. 2004;61:461–70. https://doi.org/10.1016/j.cardiores.2003.10.025.
CAS Article PubMed Google Scholar
Lillo-Moya J, Rojas-Solé C, Muñoz-Salamanca D, et al. Targeting ferroptosis against ischemia/reperfusion cardiac injury. Antioxidants. 2021;10:1–25. https://doi.org/10.3390/antiox10050667.
Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84. https://doi.org/10.1016/j.biocel.2006.07.001.
CAS Article PubMed Google Scholar
Wang F, Yuan Q, Chen F, et al. Fundamental mechanisms of the cell death caused by nitrosative stress. Front Cell Dev Biol. 2021;9:1–10. https://doi.org/10.3389/fcell.2021.742483.
Cadenas S. ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection. Free Radic Biol Med. 2018;117:76–89. https://doi.org/10.1016/j.freeradbiomed.2018.01.024.
CAS Article PubMed Google Scholar
Bagatini MD, Martins CC, Battisti V, et al. Oxidative stress versus antioxidant defenses in patients with acute myocardial infarction. Heart Vessels. 2011;26:55–63. https://doi.org/10.1007/s00380-010-0029-9.
Singh A, Lee KJ, Lee CY, et al. Relation between myocardial glutathione content and extent of ischemia-reperfusion injury. Circulation. 1989;80:1795–804. https://doi.org/10.1161/01.CIR.80.6.1795.
CAS Article PubMed Google Scholar
Ji W, Wang L, He S, et al. Effects of acute hypoxia exposure with different durations on activation of Nrf2-ARE pathway in mouse skeletal muscle. PLoS ONE. 2018;13:1–15. https://doi.org/10.1371/journal.pone.0208474.
Valls N, Gormaz JG, Aguayo R, et al. Amelioration of persistent left ventricular function impairment through increased plasma ascorbate levels following myocardial infarction. Redox Rep. 2016;21:75–83. https://doi.org/10.1179/1351000215Y.0000000018.
CAS Article PubMed PubMed Central Google Scholar
Wang Z, Kim S, Quinney SK, et al. Non-compartment model to compartment model pharmacokinetics transformation meta-analysis—a multivariate nonlinear mixed model. BMC Syst Biol. 2010;4:1–7. https://doi.org/10.1186/1752-0509-4-S1-S8.
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